TOBACCO USE

This study is testing whether offering smokers who aren't ready to quit a choice of alternative nicotine products (like e-cigarettes, heated tobacco, or nicotine pouches) helps them reduce or stop smoking cigarettes. Participants will receive a 4-week supply of their chosen produ…

This study is testing whether switching to very low nicotine cigarettes helps people with chronic pain and opioid use disorder reduce their smoking. Researchers will compare these special cigarettes to regular cigarettes to see which better reduces cravings, withdrawal symptoms, …

This study aims to find out if switching completely to e-cigarettes (vapes) is a better way to help people quit smoking while they are in treatment for substance use disorders, compared to using standard nicotine patches and lozenges. It involves 240 adults in South Carolina who …

This small pilot study is testing whether giving cancer patients an indoor air quality monitor helps them keep their homes smoke-free. Researchers want to see if using the monitor for two weeks is practical and if patients attend related workshops. The goal is to improve air qual…

This study aims to see if e-cigarettes or oral nicotine pouches can help persistent cigarette smokers switch away from smoking. Researchers will enroll 200 adult smokers who have tried to quit before and randomly assign them to use one of these alternatives for 6 weeks. The main …

This study is testing if a cannabis compound called CBD, taken as a pill, can help people quit smoking tobacco. Researchers at Johns Hopkins will give CBD or a placebo to 50 adult smokers who want to quit, and measure if it helps them stay smoke-free during short practice quit at…

This study is testing whether a longer, more intensive support program helps people experiencing homelessness quit smoking. It compares 6 months of coaching and nicotine patches to a standard 3-month program. The goal is to see which approach leads to more people successfully qui…

This study is testing whether the flavor of an e-cigarette makes it easier for long-term smokers to switch from regular cigarettes. Researchers will give 210 persistent smokers either fruit, tobacco, or menthol flavored e-cigarettes to use for six weeks instead of smoking. The go…

This study is testing a new, more flexible strategy to help people living with HIV who smoke. Instead of focusing only on quitting completely, it also helps participants reduce smoking, get screened for lung cancer, and manage blood pressure and cholesterol. The goal is to lower …

This study aims to find the best way to help people quit smoking to prevent cancer. It will compare two different support strategies for 5,000 current tobacco users. One strategy uses gentle reminders and nudges, while the other focuses on standard quit-focused care.

This study is testing if adults with COPD and chronic bronchitis feel better if they switch from regular cigarettes to a tobacco heating system (THS), which heats tobacco instead of burning it. About 290 participants will be randomly assigned to either switch to THS or continue s…

This study observes adults with risk factors like high blood pressure or diabetes during their regular cardiology visits. Researchers will collect health data to see how structured management affects measures like blood pressure and cholesterol. The goal is to better understand h…

This study aims to understand why people with chronic pain find it harder to quit smoking. Researchers will use brain scans and smartphone surveys to see how temporary smoking withdrawal changes pain signals in the brain and affects quit attempts. The goal is to gather informatio…

This study aims to understand how very low nicotine cigarettes affect the heart compared to regular cigarettes. Researchers will measure heart rate and electrical activity in 49 smokers while they smoke different types of research cigarettes. The goal is to gather information to …

This study aims to understand how THC, the main active ingredient in cannabis, affects a person's desire to smoke cigarettes and their actual smoking behavior. Researchers at Johns Hopkins will give 100 adult participants who regularly use both cannabis and cigarettes different d…

This study aims to understand if relighting a cigarette produces more harmful chemicals than smoking it without stopping. Researchers will observe 30 adult smokers who regularly relight cigarettes, measuring the smoke they produce and asking about their experience. The goal is to…

This study aims to understand how different oral nicotine products affect smokers compared to their usual cigarettes or nicotine gum. It will measure cravings, feelings, and nicotine levels in the blood. About 40 adult smokers will stay at a clinic for several days to try differe…

This study aims to understand what happens in the body when people use marijuana and tobacco together. Researchers will measure drug levels in the blood and physical effects like heart rate in 48 healthy adults who regularly use both substances. The goal is to gather foundational…