Cannabis compound may change how you vape

NCT ID NCT06609109

Recruiting now Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how THC, the active part of cannabis, changes people's desire for e-cigarettes and their body's response. Researchers will give different doses of THC to 100 adults who use both e-cigarettes and cannabis, then measure how much they vape, their cravings, heart rate, and thinking skills. The goal is to learn more about how cannabis and tobacco interact, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: THC (tetrahydrocannabinol) and nicotine
What this could lead to: If successful, this could help understand how cannabis influences tobacco use, potentially guiding future treatments for dual addiction.
What could go wrong: This is an early Phase 1 study with only 100 participants, so results may not apply broadly. It measures short-term effects, not long-term outcomes.

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Conditions

The condition(s) this trial relates to.

cannabis dependence nicotine dependence Tobacco Use Vaping

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANNABIS USE ELECTRONIC CIGARETTE USE TOBACCO USE

Contacts and locations

Locations

Johns Hopkins University Behavioral Pharmacology Research Unit
RECRUITING

Baltimore, Maryland, 21224, United States

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