Which E-Cigarette designs are most addictive? a Head-to-Head test

NCT ID NCT07739797

Not yet recruiting Knowledge-focused Sponsor: RAI Services Company Source: ClinicalTrials.gov ↗

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This trial asks how different e-cigarette products compare to regular cigarettes in terms of nicotine delivery and appeal. About 50 adult smokers who also use e-cigarettes will try eight different products in a random order during a supervised stay. The study measures nicotine levels in the blood and participants' subjective ratings to understand the abuse potential of each product.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Electronic nicotine delivery system (ENDS) products with varying flavors and wattages, compared to usual brand cigarettes
What this could lead to: If successful, this could help regulators and manufacturers understand how different e-cigarette designs affect their appeal and addiction potential, potentially informing product standards and public health policies.
What could go wrong: This is a small, early-stage study in a controlled setting, so results may not reflect real-world use. The findings are about abuse liability, not health outcomes, and may not generalize to all smokers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cigarette Smoking nicotine dependence Smoking Tobacco Use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMOKING ( CIGARETTE) SMOKING BEHAVIORS TOBACCO USE

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