CANNABIS USE

This study tests whether varenicline (Chantix) helps people quit cigarettes and reduce cannabis use. About 200 adults in South Carolina who smoke and use cannabis will receive either the drug or a placebo, plus counseling and online tools. The goal is to see if the medication imp…

This study tests a brief computer program designed to help teenagers aged 13 to 17 reduce their use of cannabis and alcohol. Participants who are already seeking treatment for substance use will use the program and then be followed up at one and three months. The goal is to see i…

This study tests whether a brief motivational interview during a primary care visit can reduce alcohol and cannabis use in teens aged 12-17. Researchers will enroll 500 diverse young people who are at risk for substance use. The goal is to see if a short conversation can help the…

This small pilot study tests a culturally adapted group therapy called Emotional Awareness and Expression Therapy (EAET) for Israeli adults with long-term muscle or bone pain who also use medical cannabis. Participants will attend 8 weekly group sessions to explore emotional fact…

This study tests a 5-week mobile health program for young adults ages 18-29 who use cannabis frequently or use high-THC products. Participants get personalized feedback and weekly text messages to reflect on their cannabis use and personal goals. The program aims to reduce the nu…

This study looks at how high-potency cannabis affects the brain's white matter in young adults (ages 18-25) with early psychosis. Participants will take metformin daily for 6 months and undergo brain scans and questionnaires. The goal is to see if this approach is feasible for a …

This study looks at how THC (the active part of cannabis) changes people's desire to smoke cigarettes, their cravings, and physical reactions like heart rate and blood pressure. Researchers will give different doses of THC or a placebo to 100 adults who smoke both tobacco and can…

This study explores whether precise brain stimulation can lower cannabis cravings in people with schizophrenia or schizoaffective disorder. Researchers will use a type of magnetic stimulation (rTMS) on specific brain areas and measure changes in cravings and brain activity. The g…

This study looks at people having their wisdom teeth removed under deep sedation. Researchers will compare cannabis users and non-users to see if they need different amounts of sedative drugs or have different vital signs during the procedure. The goal is to understand how cannab…

This study looks at whether cannabis use is linked to more aggressive lung cancer in people under 60. Researchers will compare cannabis smokers, tobacco-only smokers, and non-smokers to see differences in tumor type and stage. The goal is to better understand the role of cannabis…

This study looks at how alcohol, cannabis, and certain medications affect falls and thinking in people with HIV. Researchers will test if a talk with a pharmacist can help. One hundred people with HIV who drink alcohol and take multiple medications will take part.

This study follows 200 teens aged 12-18 who use cannabis daily or near-daily and have mild to severe depression. Using smartphone surveys several times a day, researchers will track how recent cannabis use and withdrawal affect mood, suicidal thoughts, and urges. The goal is to u…

This study looks at how cannabis use changes brain connections in adults aged 50 and older. Researchers will use special brain scans to measure synaptic density in the hippocampus. The goal is to understand cannabis's impact on the aging brain, not to treat any condition.

This study aims to understand how young adults aged 18-24 use cannabis in their daily lives. Researchers will follow 350 regular users over two years, collecting data through a mobile app about how often they use, what products they choose, and how much they consume. The goal is …

This study is creating a registry of 1000 adults with cancer who use cannabis. Participants use a secure app to track their symptoms, cannabis use, and how they feel after using it. The goal is to collect real-world data to help patients and doctors make informed decisions about …

This study looks at how THC (the active part of cannabis) changes people's desire for e-cigarettes, their cravings, and physical reactions like heart rate. Researchers will give different doses of THC or a placebo to 100 adults who regularly use both e-cigarettes and cannabis. Th…

This study looks at how cannabis and tobacco affect the body when used together. Researchers will measure levels of THC and nicotine in the blood of 48 adults who regularly use both substances. The goal is to understand the combined health effects and inform public health policie…

This study looks at whether brain activity related to learning can predict how well teens respond to a program aimed at reducing cannabis use. Teens aged 14-17 will have a brain scan and then attend 10 weekly virtual sessions where they report their cannabis use and take drug tes…

This study looks at how alcohol and cannabis (marijuana) change brain activity and balance when used alone or together. About 99 heavy drinkers and regular cannabis users, aged 21–50, will have their brain waves measured with EEG and their balance tested after using either alcoho…

This study looks at how cannabis use changes brain function in teenagers who also have depression. Researchers will track 280 teens over time, measuring their cannabis use, depression symptoms, and brain activity. The goal is to better understand the relationship between cannabis…

This study is testing whether a saliva (spit) test can accurately show if someone has used cannabis in the past few days, all done from home. Researchers will enroll 200 people aged 18-30 who use cannabis at least once a week. Participants will collect their own saliva samples at…

This study looks at how cannabis use and stopping it affect sleep, daily rhythms, and sensitivity to light in healthy young adults aged 18-25. Researchers will compare regular cannabis users to non-users using sleep monitors, light tests, and pupil measurements. The goal is to un…

This study looks at how different forms of cannabis edibles—chocolates, gummies, and drinks—affect thinking, behavior, and blood levels. Healthy adults aged 21-55 will take part in 9 sessions, each involving an overnight stay and tests of memory, attention, and driving skills. Th…