Teen cannabis use and depression: brain scans reveal hidden links

NCT ID NCT06941298

Recruiting now Knowledge-focused Sponsor: University of Miami Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how cannabis use changes brain function in teenagers who also have depression. About 280 teens will have brain scans (fMRI) and answer questionnaires at the start and again one year later, with a second year of follow-up. The goal is to understand the connection between cannabis, mood, and brain activity, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help us understand how cannabis use changes brain activity in teens with depression, pointing toward better prevention or treatment strategies.
What could go wrong: This is an observational study, not a treatment trial. It will not directly test a new therapy, and results may not apply to all teens or lead to immediate clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANNABIS USE DEPRESSION

Contacts and locations

Locations

Nathan Kline Institute
NOT_YET_RECRUITING

Orangeburg, New York, 10962, United States
University of Miami Clinical Research Building
RECRUITING

Miami, Florida, 33136, United States

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