University Of Miami

This study is testing whether combining two drugs, epcoritamab and loncastuximab tesirine, is safe and effective for adults with large B-cell lymphoma that has returned or stopped responding to prior treatments. The main goal is to see if the combination can reduce or eliminate c…

This study is testing whether cancer survivors who get a personalized referral to a nutrition and exercise program will adopt healthier habits. It's enrolling 306 people who have finished treatment for breast, prostate, or colorectal cancer but aren't currently meeting standard d…

This small pilot study is testing whether adding a weight loss medication called tirzepatide (Zepbound) and a specific diet to standard Crohn's treatment can improve disease control. It will enroll 24 adults with mild Crohn's disease who are overweight and already on stable biolo…

This study is testing a new mobile phone app that sends text messages to help women living with HIV stick to their treatment plans. The messages provide reminders for appointments and medications, and also offer support to address challenges like stigma and mistrust of the health…

This study aims to understand how a maintenance drug called niraparib works in women of African ancestry who have ovarian cancer. Researchers want to see if genetic background affects the drug's safety, side effects, and how the body processes it. The goal is to help control the …

This study aims to see if adding an inhaled corticosteroid (ICS) to a standard two-drug inhaler for 4 weeks improves how well the blood vessels in the lungs work for people with stable COPD. Researchers will measure changes in lung blood vessel resistance and breathing tests in 3…

This study is testing whether a therapy called functional electrical stimulation (FES) can help restore arm and hand function in people with spinal cord or peripheral nerve injuries. Researchers will use a device called MyndMove to deliver gentle electrical pulses to nerves and m…

This study is testing a new approach for treating rectal cancer that has not spread. The goal is to see if giving chemotherapy first, followed by a higher dose of targeted radiation, can completely eliminate the tumor. If successful, this could allow patients to avoid major surge…

This study is testing whether a specially designed anti-inflammatory diet featuring common American foods like sandwiches, grilled meats, and smoothies can help put ulcerative colitis into remission. Researchers will enroll 122 American patients with active ulcerative colitis to …

This study is testing whether deep brain stimulation can help people with spinal cord injuries walk better. Researchers will implant a small device in the brain to deliver electrical pulses to a specific area involved in movement. The trial involves 6 participants with incomplete…

This study is testing whether combining a cancer drug (regorafenib) with a targeted radiation treatment (Y-90 radioembolization) can better control advanced liver cancer that cannot be removed by surgery. It will enroll 30 adults who have not had prior drug treatment for their ca…

This study tests whether community health workers can help people with moderate-to-severe sleep apnea use their breathing machine more consistently. Researchers will compare motivational support from trained community workers against standard care. The goal is to improve treatmen…

This study is testing whether collagenase injections can safely reduce penile curvature in men with Peyronie's disease who previously received platelet-rich plasma treatment. Researchers will measure changes in curvature and ask participants about symptoms and sexual function. Th…

This small pilot study is testing whether gentle electrical stimulation of nerves in the ear is safe for people with chronic spinal cord injuries. Researchers want to see if this non-invasive stimulation might help improve heart health and blood sugar control, which are common co…

This study is testing a new combination of three drugs—elranatamab, lenalidomide, and dexamethasone—for people newly diagnosed with multiple myeloma, a blood cancer. The main goal is to see if this treatment can achieve a deep remission, meaning no detectable cancer cells remain …

This study is testing if an oral medication called probenecid can improve sperm movement in men with spinal cord injuries, a common cause of infertility in this group. It will involve 90 men with spinal cord injuries to see if the treatment helps their sperm swim better. The goal…

This study is testing if a long-acting eye implant (Durysta) can help people with glaucoma who use daily eye drops. The goal is to see if the implant reduces the number of drops needed and lessens eye surface inflammation and discomfort. Researchers will measure inflammation leve…

This study is testing whether a new therapy that combines a brain-computer interface with spinal cord stimulation can help people with incomplete spinal cord injuries walk better. Researchers will work with 12 participants who have some leg movement to see if this technology impr…

This small pilot study is exploring whether a combination of counseling to reduce alcohol use and taking a probiotic supplement can improve thinking skills and brain metabolism in older adults who are heavy drinkers. Researchers will measure changes in memory, attention, and how …

This study is testing a new therapy that uses magnetic brain stimulation, electrical spinal cord stimulation, and muscle stimulation together. The goal is to see if this combination can improve hand, leg, and trunk movement and control in people with spinal cord injuries. The stu…

This study is testing whether a simple blood test that looks for cancer DNA can help doctors choose between two standard drugs for advanced gastrointestinal cancer. Researchers want to see if patients with specific DNA changes respond better to one drug versus the other. The goal…

This study is testing whether a combination of three drugs—selinexor, venetoclax, and dexamethasone—can better control a specific type of advanced multiple myeloma that has returned or stopped responding to other treatments. It is for patients whose cancer has a particular geneti…

This study is testing whether gently cooling the body after a serious neck spinal cord injury can help patients regain movement and function. Researchers are enrolling 120 adults who recently suffered this type of injury across multiple hospitals. The cooling treatment must begin…

This study is testing an experimental drug called loncastuximab tesirine in adults whose marginal zone lymphoma has returned or stopped responding to standard treatments. Researchers want to see if the drug can shrink or eliminate tumors and how safe it is for patients. The study…

This study is testing whether adding a trained community helper to a standard parent-child therapy program helps underserved families in Miami stay engaged and complete the treatment. It aims to see if this extra support leads to better child behavior, improved parenting skills, …

This study is testing a shorter version of a powerful six-drug chemotherapy combination (called BrECADD) for adults with advanced Hodgkin lymphoma. The main goal is to see if this shorter treatment plan can effectively control the cancer while being more tolerable for patients. R…

This study is testing a therapy program designed to help children and teenagers manage anxiety and depression. It involves both the young person and their parent or caregiver. Researchers want to see how well this specific type of talk therapy works by measuring changes in sympto…

This study is testing a counseling program designed to help Black women who are living with HIV and have experienced trauma. The goal is to see if this program helps them take their HIV medication more consistently and improves their mental health. Researchers will measure change…

This study is testing a new way to deliver cancer drugs directly to the brain for children and young adults whose brain tumors have come back or haven't responded to standard treatments. Doctors use a tiny catheter to deliver two existing drugs (cetuximab and bevacizumab) precise…

This study is testing whether a supervised exercise program can help children and young adults (ages 12-39) with newly diagnosed sarcoma better tolerate their chemotherapy. Researchers want to see if staying active during treatment helps patients receive more of their planned che…

This study is testing whether a brain-computer interface can help people with spinal cord injuries regain hand function. Researchers will use brain signals to control spinal cord stimulation, aiming to improve grasping and movement. The small trial involves 3 adults with chronic …

This study is testing a new, focused approach to treating prostate cancer. For early-stage patients, doctors will deliver one high-dose radiation session directly to the tumor, not the whole prostate, aiming to cure the cancer. The trial will also see if adding a very short cours…

This study compares two different swallowing tests to see which one better identifies swallowing problems and aspiration risk in stroke patients during rehabilitation. Researchers will enroll 50 adults who recently had a stroke and are in rehabilitation. The goal is to determine …

This study is testing a blood test that measures a substance called endotoxin. The goal is to see if this test can predict which patients are at high risk for developing serious infections after surgery to remove kidney stones. Researchers will enroll 150 adults having this speci…

This study tests two different telehealth approaches to deliver a package of health services to people who inject drugs. The program offers medications to prevent HIV, cure hepatitis C if needed, and treat substance use disorders if desired. Researchers will enroll 350 participan…

This study aims to prevent the spread of HIV and Hepatitis C among people who inject drugs. Researchers are testing a new support strategy for syringe service programs to help them offer routine, easy-to-get testing. The goal is to find more infections early and connect people to…

This study is testing a program for parents of Hispanic LGBTQ+ teenagers. The goal is to see if teaching parents how to be more supportive can help prevent or reduce depression and drug use in their teens. Researchers will work with about 300 families in South Florida to see if i…

This study aims to find the best aspirin dose to prevent dangerous blood clots after hip or knee replacement surgery. It will compare taking one low-dose aspirin pill per day versus taking two. The goal is to determine which schedule is more effective and safer for patients recov…

This study is testing a new community program designed to help Latinx men at risk for HIV start and consistently take prevention medication (PrEP). It combines easy-access pharmacy services with a social support network. The goal is to see if this approach is more effective than …

This study tests whether training workplace safety managers to help construction workers quit smoking makes programs more effective and affordable. It compares three different approaches to find the best balance of success, cost, and practicality for construction companies. The g…

This study is testing a new system called the JUNTOS Referral Network. It aims to help HIV test counselors better connect Latino men who have sex with men to important prevention services like PrEP and HIV treatment. The goal is to see if this network improves how many men get re…

This study is testing a digital program called 'Healthy Together' (Juntos) that uses a website and smartphone app. It aims to help Hispanic teens and their parents improve diet, increase physical activity, and prevent unhealthy weight gain. The program focuses on family support a…

This study is testing if a 'food prescription' program can help families who struggle to afford healthy food. It will provide plant-based foods like fruits, vegetables, and whole grains, along with nutrition education, to 100 low-income families. Researchers will track if this im…

This study is testing whether a regular exercise program can improve reaction time and mouse-click accuracy for people who play video games. Researchers at the University of Miami are recruiting 15 recreational gamers to participate. The goal is to see if physical exercise leads …

This study is testing whether an over-the-counter Chinese herbal cream containing menthol can help relieve pain and itching caused by skin reactions to radiation therapy. Researchers are enrolling 40 women with breast cancer who will receive radiation after mastectomy. The study …

This study is testing if the medication duloxetine (Cymbalta) can help reduce the need for strong opioid painkillers after total hip replacement surgery. Researchers will compare duloxetine to a placebo in 64 adults having this surgery. The main goal is to see if patients taking …

This study aims to help people with gastrointestinal cancer and their sleep partners get better rest. Researchers are testing two different sleep improvement programs to see which works better. The study will measure changes in sleep quality and insomnia symptoms for both patient…

This study is testing a brief, free online program designed to help caregivers of children with anxiety. The 30-minute session teaches skills to better support anxious children and reduce family stress. Researchers are adapting the program for Latin, Haitian, and Haitian-American…

This study is testing whether a combination of ice packs, medicated witch-hazel pads, and numbing spray helps reduce pain after vaginal surgery. Researchers will compare pain levels and medication use between women who receive this combination and those who receive standard care.…

This study is testing two skin treatments for people with rosacea, a condition that causes facial redness and bumps. Researchers will treat one side of a participant's face with a green laser and the other side with the same laser plus a microneedling device. The goal is to see w…

This study compares two different surgical cuts used during hip replacement surgery in obese patients. Researchers want to see which cut heals better and leaves a less noticeable scar. They will measure how long it takes the wound to heal and ask patients how satisfied they are w…

This study is testing a behavioral therapy program called CBIT to help children and teenagers manage tic disorders. Researchers want to see how well the therapy reduces tics and improves daily life, and understand what factors make it work best. The study will enroll 200 youth wi…

This study compares two types of weight training for people with Parkinson's disease. Researchers want to see if lifting heavier weights fewer times or lighter weights more times is better for improving muscle strength and daily activities like walking and standing up. The study …

This study is testing whether a special flexible tube placed in the throat can help keep oxygen levels stable during a heart ultrasound procedure. Researchers will compare it to standard oxygen delivery through the nose in 50 adults who are sedated for the test. The goal is to se…

This study aims to understand the physical activity challenges faced by people with hidradenitis suppurativa (HS), a chronic skin condition. Researchers will design and test a special exercise program for 50 adults with HS to see if it can improve their strength, walking ability,…

This study aims to see if Botox injections can help reduce painful sensitivity to light in people who have had a traumatic brain injury. Researchers will enroll 50 adults who have experienced light sensitivity for at least six months. The main goal is to measure changes in pain l…

This study aims to find the best way to help parents struggling with intense grief after losing a child to cancer. Researchers will compare three different types of support programs to see which one most effectively reduces symptoms of prolonged grief and depression. The study is…

This study is testing whether watching virtual reality (VR) videos can help reduce anxiety and improve the overall experience for people receiving radiation therapy for cancer. Researchers will compare different VR experiences against a standard educational video to see which wor…

This study aims to see which of two different strength training programs works better for people with Parkinson's disease. Researchers will compare a traditional power training program to a newer 'block periodization' method that cycles through different types of exercises. The g…

This study is testing whether following a Mediterranean diet and doing home-based exercise during chemotherapy can help lymphoma patients better complete their treatment and reduce treatment-related side effects. Researchers will enroll 140 adults with lymphoma who are starting c…

This study compares two common anesthesia methods—spinal (numbing from waist down) versus general (fully asleep)—for patients getting hip or knee replacements. Researchers want to see which approach leads to better recovery, including less pain and nausea, shorter hospital stays,…

This study is testing if a combination of visual body illusions and a gentle, non-invasive brain stimulation technique can reduce chronic nerve pain in people with spinal cord injuries. Researchers will measure changes in pain severity, how much pain interferes with daily life, a…

This study is testing if common anti-inflammatory painkillers (like ibuprofen) can effectively manage pain after robotic kidney cancer surgery, with the goal of reducing the need for stronger opioid medications. It will involve 110 adults undergoing this specific surgery at the U…

This study is testing a new digital game designed to help parents and children play together to build stronger relationships. Researchers want to see if playing the game improves parents' confidence in their parenting skills and helps families feel closer. The study is recruiting…

This study is testing a new sensory training program to help people with mild traumatic brain injuries who have ongoing symptoms like dizziness, headaches, and vision problems. Researchers will enroll 80 adults who have had symptoms lasting over a month after their injury. The go…

This study aims to understand why some patients develop protein in their urine immediately after receiving a kidney transplant, especially those with a specific kidney disease called FSGS. Researchers will review medical records and analyze blood and kidney tissue samples from up…

This study is testing whether a simple blood test can tell doctors if chemotherapy is working for metastatic pancreatic cancer faster than the current standard of waiting 8 weeks for scans. Researchers will measure tumor DNA in the blood of 50 participants at different time point…

This study follows healthy people who have family members with ALS and carry genetic risk factors, but don't yet have symptoms. Researchers will track participants over 10+ years to understand what happens in the body before ALS develops and identify early warning signs. Particip…

This study aims to understand if obstructive sleep apnea (OSA) is connected to problems in how the body breaks down and uses fat. Researchers will compare fat metabolism in 100 people with and without sleep apnea. They will measure substances released by fat tissue and see how th…

This study aims to learn about the experiences of cancer patients who use a mobile app called EveryDose to track their oral medication. Researchers will enroll about 25 adults who are taking oral anti-cancer drugs for the first time. The goal is to gather feedback on the app's us…

This study aims to understand how eating high-fat meals affects inflammation and pain sensitivity in people living with chronic spinal cord injury. Researchers will compare blood markers and pain tests after participants eat different meals. The goal is to learn how body composit…

This study aims to gather a large group of people to help researchers learn more about ALS. It will recruit 10,000 participants, including people with ALS, their family members, and healthy volunteers. The goal is to understand the disease better by tracking its course and identi…

This study aims to understand if the drug sirolimus changes the molecular activity inside brain aneurysms. It will enroll 80 adults with unruptured brain aneurysms who are already scheduled for surgery. Researchers will compare gene activity in tissue and blood samples from patie…

This study aims to understand how eating affects the connection between the brain and stomach in people with and without spinal cord injury. Researchers will measure brain and stomach activity in 28 adults to see how they communicate. The goal is to gather basic knowledge about t…

This study aims to understand how being born prematurely affects kidney development and long-term health. Researchers will follow 300 preterm babies for up to 10 years, using blood tests, urine tests, and ultrasounds to track kidney growth and function. The goal is to identify ea…

This study is testing whether adding a sense of touch (haptic feedback) to virtual reality learning games helps students learn reading and spelling skills. Researchers will enroll 60 students aged 6 and up to use VR gloves that vibrate during literacy games. The goal is to unders…

This study aims to discover if unconscious brain injury patients who show brain activity in response to music and language during a simple bedside test are more likely to recover consciousness and function. Researchers will track 300 adults with traumatic brain injury or hemorrha…

This study aims to collect blood samples from people who have received or donated stem cell transplants for cancer, as well as from healthy individuals. Researchers will analyze these samples in a lab to learn how the immune system rebuilds itself after treatment. The goal is to …

This study aims to understand how to better include Black and Hispanic people in remote heart health research. It will test if using smartphones helps people with conditions like high blood pressure or diabetes stick with a study program. The goal is to learn how to make future m…

This study aims to learn the best way to help people with non-medical issues that affect their health, like food insecurity or trouble getting medical care. Researchers will compare the support from trained community health workers to simply giving people informational reading ma…

This study aims to understand how the services from the nonprofit Blood Cancer United affect people with blood cancers. Researchers will follow 400 patients for six months to see if the organization's help improves their access to medical care, quality of life, and financial stre…

This study aims to understand how prostate cancer responds to standard radiation treatment by tracking changes in blood tests and imaging scans over time. Researchers will follow 144 patients undergoing radiation therapy or surgery to see if certain markers in blood and scans can…

This study aims to understand how opioid use affects the body's immune response to the flu vaccine, particularly in people living with HIV. Researchers will collect and analyze blood samples from 400 adults who either use opioids or don't, and who either have HIV or don't. The go…

This study aims to find the most practical exercise progression method for older adults. Researchers will compare two different power training approaches in 45 healthy participants aged 50-90. The goal is to understand which method best improves strength, walking speed, and daily…

This study aims to learn more about ALS and related diseases by collecting health information from patients' medical records. It will enroll up to 1,200 people with ALS, PLS, or PMA who receive care at specific clinics. The goal is to build a detailed picture of how these disease…

This study aims to understand what helps or prevents head and neck cancer patients from using support services before treatment. Researchers will offer 60 patients nutritional counseling and exercise programs before they start radiation or chemotherapy. The main goal is to learn …

This study is testing whether an educational program helps people who recently had a spinal cord injury understand their increased risks for heart disease, obesity, and diabetes. Researchers will enroll 250 adults within 4 months of finishing their initial rehab. The main goal is…