University Of Miami

This study tests a new way to treat prostate cancer using a single, high-dose radiation session aimed only at the tumor, not the whole prostate. For early-stage patients, this may be enough to cure the cancer. For higher-risk patients, the single session is followed by standard r…

This study tests whether community health workers (CHWs) can help Black people with poorly controlled HIV achieve long-term viral suppression. CHWs provide support through weekly phone calls, home visits, and clinic accompaniment for three months. The study enrolls 10 Black adult…

This study looks at how well women of African ancestry with ovarian cancer tolerate a maintenance drug called niraparib after initial treatment. Researchers want to see if genetic or environmental factors affect side effects and how the drug works. About 70 women will take nirapa…

This early-stage study tests a combination of antiretroviral drugs (normally used for HIV) and a laser procedure to treat high-grade gliomas—aggressive brain tumors that cannot be surgically removed. About 24 adults with newly diagnosed tumors will receive the laser treatment fol…

This study tests whether combining a drug called axatilimab with a blood-filtering procedure (ECP) can help people with chronic graft-versus-host disease (cGVHD), a complication after a stem cell transplant. About 49 participants who have tried at least two prior treatments will …

This study investigates whether a mobile app called reSET can help men who have sex with men, are living with HIV, and have a stimulant use disorder reduce their drug use and keep their HIV under control. Participants use the app for 12 weeks, completing modules on topics like ma…

This study tests whether giving radiation to the para-aortic lymph nodes (located in the abdomen) can better control prostate cancer that has returned in a limited number of spots. Men with hormone-sensitive prostate cancer and up to five lesions seen on a PSMA PET/CT scan will r…

This study tests injecting the chemotherapy drug cisplatin directly into throat cancer tumors that have come back after radiation. About 20 adults will receive the injection before planned surgery to remove the tumor. Researchers will check how many tumors shrink or disappear and…

This study tests two drugs, pembrolizumab and lenvatinib, in people with a type of uterine cancer that has come back after initial treatment. The cancer must be mismatch repair proficient, meaning it has a specific genetic feature. The goal is to see if this drug combination can …

This study tests whether functional electrical stimulation (FES) can improve arm and hand function in people with spinal cord or peripheral nerve injuries. Researchers will use the MyndMove device to stimulate muscles during short therapy sessions. The goal is to see if this appr…

This study looks at whether eating a controlled Mediterranean diet before prostate cancer surgery can improve health markers like insulin levels. Twenty men scheduled for prostate removal will receive pre-made meals and be monitored. The goal is to see if this diet is practical a…

This study tests whether briefly soaking a donor cornea in a solution made from the patient's own blood (PRGF) before transplant surgery can reduce the loss of important cells after the operation. About 100 people with Fuchs' endothelial dystrophy or corneal swelling will take pa…

This study tests whether a diet made from common American foods like sandwiches, grilled meats, and oatmeal can reduce inflammation and improve symptoms in people with ulcerative colitis. Over 8 weeks, 122 participants will receive catered meals and guidance from a dietitian. The…

This pilot study tests whether the weight-loss drug tirzepatide (Zepbound) combined with a Mediterranean diet can help control mild Crohn's disease. Twenty-four adults with Crohn's who are already on biologic therapy and have a BMI of 27 or higher will receive either tirzepatide …

This study looks at whether monitoring the immune response to the cytomegalovirus (CMV) can help prevent CMV disease in people who receive a lung transplant. About 100 adult lung transplant patients who have had CMV in the past will be followed. The goal is to see if tracking CMV…

This study tests whether sirolimus, a drug used to prevent organ rejection, can reduce harmful inflammation inside brain aneurysms. Researchers will give the drug to some patients before standard surgery or coiling and compare tissue and blood samples to those not receiving the d…

This phase 2 study is testing whether combining two drugs—epcoritamab and loncastuximab tesirine—can safely shrink or eliminate lymphoma in people whose large B-cell lymphoma has come back or not responded to treatment. About 26 adults will receive the drugs over several cycles. …

This phase 2 trial is testing whether a combination of three drugs (selinexor, venetoclax, and dexamethasone) can shrink tumors in people with a specific genetic subtype of multiple myeloma called t(11;14) that has come back or stopped responding to treatment. About 33 participan…

This study tests whether combining a targeted immunotherapy (tebentafusp) with a liver-directed radiation treatment (Y-90 radioembolization) can help control metastatic uveal melanoma that has spread to the liver. About 30 adults whose cancer is mainly in the liver and who have a…

This early-phase trial is testing whether giving chemotherapy first, followed by a higher-than-usual dose of MRI-guided radiation, can eliminate tumors in people with locally advanced rectal cancer. The goal is to see if this approach is safe and can lead to a complete response, …

This study aims to reduce food insecurity by providing plant-based food prescriptions to 100 low-income families. Participants will track their intake of fruits, vegetables, whole grains, legumes, and nuts/seeds. The goal is to improve access to healthy food and nutrition knowled…

This study is testing a mobile health app designed to help women living with HIV remember their medications, appointments, and prescription refills. The app also addresses barriers like stigma and mistrust of the medical system. Researchers will enroll 80 women to see if the app …

This study tests whether giving two drugs (cetuximab and bevacizumab) directly into the brain's blood vessels each month is safe and can shrink tumors or slow their growth. It includes children and young adults under 22 with certain types of brain tumors that have come back or no…

This study is testing whether cooling the body to 33°C (just below normal) for 48 hours soon after a cervical spinal cord injury can improve nerve recovery and function. Researchers will enroll 120 adults aged 18-70 with severe but non-penetrating injuries. The cooling is deliver…

This phase 2 trial is testing a shortened course of a drug combination called BrECADD for people with advanced Hodgkin lymphoma. The goal is to see if a shorter treatment can still control the cancer while reducing side effects. About 48 adults aged 18 to 60 will receive up to fo…

This Phase 2 trial tests whether combining elranatamab (an immune-boosting drug) with lenalidomide and dexamethasone can eliminate all traces of multiple myeloma in newly diagnosed patients. About 104 participants will receive the drugs in cycles over several months. The main goa…

This study tests a drug called loncastuximab tesirine in 50 adults with marginal zone lymphoma that has returned or not responded to prior treatments. The drug is given as an IV infusion over several cycles. Researchers want to see if it can shrink tumors and control the disease …

This study tests a 10-session counseling program called STEP-AD for Black women living with HIV who have a history of trauma. The goal is to help them stick to their HIV medication and achieve viral suppression. Researchers will enroll 250 participants and compare the program to …

This early study tests whether a brain-computer interface can detect a person's intention to move their hand and then trigger electrical stimulation in the spinal cord to help produce that movement. Three adults with chronic spinal cord injury will have temporary spinal electrode…

This study tests a new therapy that uses a brain-computer interface to detect when a person tries to move, then activates spinal cord stimulation to help them walk. It is for people with incomplete spinal cord injury who are at least 6 months post-injury. The goal is to see if it…

This phase 2 trial tests whether DNA changes in the KIT gene can predict how well patients with advanced gastrointestinal stromal tumor (GIST) respond to two standard drugs, sunitinib and regorafenib. About 48 adults whose GIST has worsened on imatinib will receive the drugs in s…

This study tests a smoking cessation program in the construction industry, where safety managers are trained to help workers quit smoking. About 608 construction workers will receive nicotine gum and access to a telephone quit-line. The goal is to find the most effective and cost…

This study tests a program called JUNTOS that helps HIV test counselors refer Latino men who have sex with men to prevention and treatment services. The goal is to see if this referral network increases the number of men who use HIV prevention or get treated. About 245 participan…

This phase 2 trial tests whether the drug quisinostat can prevent uveal melanoma from spreading in high-risk patients. About 63 people who have completed initial treatment for their eye tumor will take quisinostat capsules three times a week. Researchers will track how long parti…

This study tests a parenting program designed to help Hispanic teens who are gay, lesbian, or bisexual. The goal is to see if the program can prevent or reduce drug use and symptoms of depression by improving family support and reducing stress. About 306 teens and their parents w…

This study looks at two strategies for getting HIV self-test kits and PrEP (a daily pill that prevents HIV) to people who might benefit. Current PrEP users will either directly give kits to friends or refer them to pick up kits. The goal is to see which method gets more people te…

This study tests a program to help Latinx men lower their HIV risk by combining easy access to PrEP medication, social support from friends, and a national pharmacy chain. Researchers will enroll 624 men aged 18-54 and track how many start and stick with PrEP. The goal is to crea…

This study tests a web and mobile program called Healthy Together ("Juntos") for Hispanic teens aged 12-15 and their parents. The goal is to prevent unhealthy weight gain and improve physical activity and diet. About 750 families will use the program to see if it helps teens stay…

This study looks at whether taking 81 mg of aspirin once a day works just as well as taking it twice a day to prevent dangerous blood clots after hip or knee replacement surgery. About 5,500 adults having joint replacement will be randomly assigned to one of the two dosing schedu…

This study compares two ways of offering HIV prevention medications, hepatitis C treatment, and substance use disorder care to people who inject drugs. Participants will receive services via telehealth and be followed for 12 months. The goal is to see which approach works best fo…

This study compares three support programs for parents who lost a child to cancer at least six months ago and still have high grief levels. The programs include Meaning-Centered Grief Therapy, Supportive Counseling, and Enhanced Usual Care. Researchers will measure changes in gri…

This study tests whether people can use a small, portable device at home to stimulate the vagus nerve through the ear. It aims to see if this approach is practical and acceptable for managing nerve pain caused by chemotherapy. The study includes 36 adults who have had platinum or…

This study looks at whether using a nasal high-flow device (which delivers warm, moist air at a high rate) can help people with COPD walk farther during a 6-minute walk test. Thirty adults with COPD will try both the high-flow device and a standard low-flow device on different da…

This study looks at whether offering nutritional counseling and exercise programs before and during radiation or chemoradiation is helpful for head and neck cancer patients. Researchers want to see if patients are willing to join and attend these sessions. The goal is to improve …

This early-stage study is testing whether using a special muscle-mapping device to guide Botox injections can better relieve chronic pelvic floor pain in women compared to the standard injection method. Researchers will enroll 30 women with long-term pelvic pain and give them two…

This study tests whether deep brain stimulation (DBS) can improve walking in people with incomplete spinal cord injury. Six adults who have had a spinal injury for at least one year will receive DBS to a brain area called the cuneiform nucleus. The goal is to see if it safely hel…

This study tests a brief online program called Project Independence for caregivers of autistic youth aged 10 to 14. The program gives practical tools to help kids build daily living skills like dressing or chores. About 70 caregivers will be randomly assigned to the program or an…

This study looks at whether a diet that includes longer overnight fasting and follows a Mediterranean eating pattern is practical for people with multiple myeloma or its early forms (MGUS or smoldering myeloma). About 120 adults will try this approach to see if they can stick wit…

This study tests whether listening to binaural beats or a patient's chosen music for 30 minutes after knee or hip replacement surgery can lower pain and anxiety. About 50 adults having these surgeries will take part. Researchers will measure pain and anxiety levels right after su…

This study tests whether a magnesium supplement called Magnesium-L-Threonate (MgT) can improve sleep quality and reduce pain in people recovering from total knee or hip replacement. Researchers will enroll 64 adults having surgery at the University of Miami Hospital. Participants…

This study tests a new approach that combines magnetic brain stimulation, electrical spinal cord stimulation, and muscle stimulation to improve hand, leg, and trunk function in people with spinal cord injury. Researchers will enroll 25 participants, including both injured and abl…

This study tests whether adding radiofrequency microneedling to a standard KTP laser treatment works better for rosacea than laser alone. Twenty adults with red, bumpy rosacea will have each side of their face treated differently. The goal is to see which approach reduces redness…

This study is testing a Chinese herbal cream (with 1% menthol) to see if it can temporarily relieve pain and itching on the chest after breast cancer radiotherapy. Forty women who have had a mastectomy and will receive radiation are being recruited. The cream is applied twice dai…

This study tests whether a single 60 mg dose of duloxetine, given before total hip replacement surgery, can reduce the amount of narcotic painkillers patients need afterward. Researchers will compare duloxetine to a placebo in 64 adults. The goal is to see if this approach leads …

This study compares two types of surgical cuts (bikini vs. longitudinal) for hip replacement in obese patients. Researchers want to see which heals faster and leaves a scar patients like more. About 110 participants will be randomly assigned to one incision type, and their recove…

This study looks at sleep habits in people with gastrointestinal cancer and their sleep partners. It tests two different programs to help improve sleep quality and reduce insomnia. About 152 patient-partner pairs will take part, and their sleep will be tracked using questionnaire…

This study tests whether a kit containing perineal ice packs, medicated witch-hazel pads, and benzocaine spray can reduce pain after vaginal surgery. Seventy women undergoing perineorrhaphy or posterior colporrhaphy will use the kit alongside standard care. The goal is to see if …

This study tests a new digital game designed to help parents and children play together and build stronger relationships. About 30 parent-child pairs will try the game, which includes activities based on relationship-building principles. Researchers will measure changes in parent…

This study tests a medicine called probenecid to see if it can improve sperm movement in men with spinal cord injury. Many of these men have normal sperm counts, but their sperm don't swim well, causing infertility. The trial will enroll 90 men and measure changes in sperm qualit…

This study tests whether a supervised exercise program can help pediatric and young adult sarcoma patients (ages 12-39) tolerate chemotherapy better. Forty newly diagnosed patients will either do weekly exercise sessions or just complete symptom surveys. The main goal is to see i…

This study looks at whether low-load or high-load resistance training works better for improving muscle strength and everyday activities in older adults with Parkinson's disease. About 60 participants with mild to moderate Parkinson's will take part. The goal is to find the most …

This study tests whether a Mediterranean diet and home-based exercise program can help lymphoma patients complete chemotherapy and reduce treatment-related side effects. Researchers will enroll 140 adults with untreated Hodgkin or non-Hodgkin lymphoma who need at least 6 cycles o…

This study is testing a behavioral treatment called CBIT (Comprehensive Behavioral Intervention for Tics) in 200 youth who have tic disorders, such as Tourette's, along with related emotional problems like anxiety or depression. The goal is to see if CBIT can reduce tic severity …

This study is testing a non-invasive device called PNRT that uses gentle light and motion to help people with lingering dizziness and other symptoms after a mild traumatic brain injury. Researchers will enroll 80 adults to see if the device is safe, tolerable, and can reduce dizz…

This study looks at whether adding a community health worker (called a natural helper) to standard parent-child therapy helps families stay in the program and see better results. About 300 families with children aged 2 to 12 who have behavior problems or a history of abuse will t…

This study looks at whether trained community health workers can motivate people with moderate-to-severe sleep apnea to use their breathing machines (PAP) more regularly. About 48 adults who have never used PAP before will receive either motivational coaching or standard care. Th…

This study tests whether watching a virtual reality video about radiotherapy before treatment can lower anxiety in cancer patients. About 150 adults with cancer will be randomly assigned to see a standard 2D video, a first-person VR video, or a third-person VR video. Researchers …

This study tests a short, 30-minute online program for caregivers of children aged 4-10 with anxiety. The program is adapted for Latin, Haitian, and Haitian-American families. Researchers want to see if it reduces caregiver anxiety and helps them better support their child.

This study tests whether combining bodily illusions (like the rubber hand illusion) with mild brain stimulation (tDCS) can reduce neuropathic pain in people with spinal cord injury. Thirty participants will undergo 10 sessions over 2-4 weeks. The goal is to see if these technique…

This study looks at whether a structured exercise program can improve reaction time and mouse-click accuracy in recreational video game players. Researchers will measure changes in speed and precision using simple computer tests. The study aims to see if physical activity can enh…

This study tests a special airway device (McMurray Enhanced Airway) to see if it helps patients breathe better during a heart ultrasound (TEE) while sedated with propofol. About 50 adults having an elective TEE will be enrolled. The goal is to reduce the chance of low oxygen leve…

This study is testing a therapy program called the Unified Protocol for Children (UP-C) and Adolescents (UP-A) to help young people aged 7-17 with anxiety, depression, or other emotional difficulties. The program involves up to 24 sessions with a therapist, either in groups or in…

This study tests whether a non-steroidal anti-inflammatory drug (NSAID) called ketorolac can control pain after robotic kidney surgery better than standard opioids. About 110 adults having a partial nephrectomy for kidney cancer will be randomly assigned to receive either ketorol…

This study tests whether Botox injections in the forehead can reduce light sensitivity in people who have had a traumatic brain injury. Fifty adults with chronic light sensitivity will receive a single treatment. Researchers will measure changes in pain and visual function over t…

This study investigates how depression and cannabis use together affect brain circuits involved in reward and pain in young people living with HIV. Researchers will use MRI scans and questionnaires to measure brain activity, mood, and substance use. The goal is to understand why …

This study compares two sets of strategies to help HIV clinics in Cape Town, South Africa, treat depression and improve medication adherence. Ten clinics will be randomly assigned to receive either basic support or enhanced training and supervision. Researchers will track how man…

This study gathers information from the medical records of 1,200 people with ALS and similar conditions. Researchers will use this data to better understand the disease and improve future studies. No experimental treatments are given—the goal is simply to learn from real-world pa…

This study looks at whether it is safe for women with endometrial cancer to fast overnight before their surgery. Many women with this cancer have high blood sugar and inflammation, which may help the cancer grow. The study will check if fasting is doable and liked by patients, an…

This study is testing a mobile app called EveryDose to see if it helps cancer patients take their oral chemotherapy medications on time. About 25 adults with cancer who are starting a new oral chemo drug will use the app for 12 weeks. The goal is to learn if the app is easy to us…

This study is looking at how vaping affects blood vessels, especially in the lungs. Researchers will compare current vapers (ages 18-40) to healthy non-smokers and non-vapers. They will measure blood flow in the lungs and arms to see if early damage is happening. The goal is to u…

This study uses advanced lung imaging to see how two asthma medications—albuterol alone and albuterol combined with budesonide—change airflow and blood flow in the lungs. About 40 adults with asthma will undergo scans before and after taking the medications. The goal is to better…

This study uses smartphone tracking and brain scans to see how your daily emotions, thoughts, and actions are linked. About 100 adults will answer quick surveys and share location data for four months. The goal is to better understand patterns in mood and thinking, not to test a …

This study looks at how aware Hispanic/Latinx head and neck cancer survivors are about their risk of developing a second lung cancer and the recommended screening. Researchers will provide tailored education and conduct interviews to understand barriers to screening. The goal is …

This study compares a standardized swallow test (MASA) with the usual non-standardized test to see which better detects swallowing problems and risk of food or liquid entering the lungs in stroke patients. Researchers will test 50 adults recently hospitalized after an ischemic st…

This study looks at how different meals affect energy use and appetite in men with high spinal cord injury (T6 and above) compared to able-bodied men. Participants will eat standardized meals and have their metabolism measured. The goal is to understand how food impacts cardiovas…

This study looks at how cannabis use changes brain function in teenagers who also have depression. About 280 teens will have brain scans (fMRI) and answer questionnaires at the start and again one year later, with a second year of follow-up. The goal is to understand the connecti…

This study aims to see if a specially designed education module helps people with spinal cord injury (SCI) learn about their increased risk for heart disease, obesity, and metabolic problems. Researchers will enroll 250 adults with SCI and measure changes in knowledge, body weigh…

This pilot study is testing whether a special MRI scan can measure a substance called 2-hydroxyglutarate (2HG) in brain tumors (gliomas) without needing surgery. Researchers will compare the MRI results with measurements from actual tumor tissue removed during surgery. If the MRI…

This study tests whether improving sleep with a special headband and doing mild exercise twice a week can lower biological markers linked to dementia. Thirty adults with mild memory or thinking problems will use the DREEM 2 headband for sleep therapy and follow a guided exercise …

This pilot study is testing how much irrigation fluid is needed to clear contaminants during revision knee replacement surgery for infection. Surgeons will apply a blue dye to the knee joint and wash it out in measured steps until the dye is gone. The goal is to gather data to de…

This study is for 1,000 adults with early blood conditions called MGUS or smoldering multiple myeloma. Researchers want to find out why some people's conditions stay stable while others progress to active multiple myeloma. Participants will provide samples and have regular check-…

This study looks at whether obstructive sleep apnea (OSA) changes how the body processes fat. Researchers will compare fat metabolism in 100 adults with and without sleep apnea using glucose tests. No treatment is given; the goal is to better understand how OSA might affect energ…

This study, called CRiALS, is a large umbrella protocol that aims to recruit up to 10,000 people. It includes individuals with ALS or related neurodegenerative diseases, their family members, and healthy volunteers. The main goal is to build a pool of participants for a variety o…

This study follows healthy people who have a family history and genetic risk for ALS. Researchers want to find early warning signs and understand what triggers the disease. Participants do not receive any treatment, but their health is tracked over time. The goal is to learn how …

This study looks at how eating a high-fat meal affects pain sensitivity and inflammation in people with chronic spinal cord injury. Researchers will compare a high-fat meal to a moderate-fat meal in 40 adults. They aim to understand links between body composition, diet, and pain.

This study compares general anesthesia (being fully asleep) with spinal anesthesia (numbing only the lower body) for people having hip or knee replacement surgery. Researchers will track recovery time, pain, nausea, infections, and other complications in about 2,400 participants.…

This study follows 300 preterm and full-term infants from birth to age 10 to see how their kidneys grow and function. Researchers use ultrasound and blood/urine tests to find early markers of kidney injury and high blood pressure. The goal is to identify at-risk children before t…

This study is collecting blood samples and imaging scans from 144 prostate cancer patients before, during, and after standard radiation therapy. Researchers want to see if changes in circulating tumor cells and MRI/PET imaging features can help predict how well the cancer respond…

This study looks at whether a slow-release injection (Durysta) can replace some daily eye drops for glaucoma, reducing eye surface inflammation. Researchers will measure a marker called caspase-1 in 20 adults with open-angle glaucoma. The goal is to see if fewer drops lead to a h…

This pilot study tests whether a combination of reducing alcohol and taking a probiotic supplement can improve thinking skills and brain metabolism in healthy older adults (ages 65-84) who are heavy drinkers. Twenty participants will receive either a probiotic or a placebo for 30…

This study explores whether adding touch sensations (haptic feedback) to virtual reality can help people learn to read. Researchers at the University of Miami will have 60 participants, aged 6 and up, use special gloves that vibrate and track finger movements while they interact …

This study looks at how services from Blood Cancer United (formerly The Leukemia & Lymphoma Society) affect people with blood cancers like leukemia, lymphoma, and myeloma. Researchers will track 400 patients over time to see if the organization helps with access to care, quality …

This study tests whether giving syringe service programs funding and training helps them offer routine HIV and hepatitis C testing to people who inject drugs. About 40 programs will either get this support or just receive a link to CDC resources. The goal is to see if more people…

This study looks at two different ways to do power training (fast, strong movements) in healthy adults aged 50-90. The goal is to find which method works best to improve muscle strength and walking speed. About 45 participants will be followed, and no drugs or treatments are bein…

This study collects blood samples from up to 700 people, including stem-cell transplant patients and their donors, to understand how the immune system recovers after transplant. Researchers will analyze immune cells and T cell subsets to learn about immune reconstitution and graf…

This study looks at how food changes the connection between the brain and stomach in people with and without spinal cord injury. Researchers will measure brain and stomach signals in 28 adults to understand gut-brain communication. The goal is to learn more about how spinal cord …

This study looks at why some kidney transplant patients, especially those with a kidney disease called FSGS, develop protein in their urine again after surgery. Researchers will examine blood and kidney tissue samples taken before and after the transplant to find the cause. The g…

This study tests whether a smartphone app and digital training can help Black and Hispanic adults with heart conditions stay engaged in their health programs. Researchers will compare a digital lifestyle app, digital literacy training, and standard care in 125 participants. The g…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can tell doctors within weeks if chemotherapy is shrinking a patient's pancreatic cancer. Currently, doctors wait about 8 weeks for a scan to see if treatment is working. The trial will enroll 50 people w…

This study is testing whether giving breast, prostate, or colorectal cancer survivors a personal referral to a tailored nutrition and exercise program helps them eat better and move more. Participants will use a Fitbit to track activity and sleep, and attend group nutrition sessi…

This study looks at whether community health workers (CHWs) can help people with non-medical problems like food insecurity and trouble getting healthcare. 900 adults from Florida communities will either work with a CHW for six months or receive educational materials on their own.…

This study looks at whether unconscious patients with brain injuries who show brain activity in response to music and language on an EEG are more likely to wake up and recover. Researchers will monitor 300 adults in the ICU, along with healthy volunteers, to see if these brain si…

This study is testing whether a blood test that measures endotoxin levels can predict the risk of infection after a type of kidney stone surgery called percutaneous nephrolithotomy (PCNL). Researchers will enroll 150 adults scheduled for this surgery and measure their endotoxin l…