Can a single pill cut opioid use after hip surgery?
NCT ID NCT06807866
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a single 60 mg dose of duloxetine, given before total hip replacement surgery, can reduce the amount of narcotic painkillers patients need afterward. Researchers will compare duloxetine to a placebo in 64 adults. The goal is to see if this approach leads to better pain control and less reliance on opioids.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- duloxetine
- What this could lead to
- If it works, this could offer a simple way to reduce opioid use and improve pain control after hip replacement surgery.
- What could go wrong
- This is a small, early-phase trial with only 64 participants. Duloxetine may not reduce pain or opioid use better than placebo, and it can cause side effects like nausea or dizziness.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Miami
RECRUITINGMiami, Florida, 33136, United States
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