Can Higher-Dose radiation spare rectal cancer patients from surgery?
NCT ID NCT05412082
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing whether giving chemotherapy first, followed by a higher-than-usual dose of MRI-guided radiation, can eliminate tumors in people with locally advanced rectal cancer. The goal is to see if this approach is safe and can lead to a complete response, potentially avoiding the need for surgery. The study involves 25 participants and focuses on tracking side effects and tumor response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- 5-fluorouracil (5-FU) chemotherapy and intensity-modulated radiation therapy (IMRT)
- What this could lead to
- If successful, this approach could allow some patients with locally advanced rectal cancer to avoid surgery by achieving a complete response through higher-dose radiation and chemotherapy.
- What could go wrong
- This is a very early phase 1 trial with only 25 participants, so safety and effectiveness are not yet proven. Higher radiation doses may increase side effects, and not all patients will achieve a complete response.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Miami
RECRUITINGMiami, Florida, 33136, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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