Can Higher-Dose radiation spare rectal cancer patients from surgery?
NCT ID NCT05412082
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing whether giving chemotherapy first, followed by a higher-than-usual dose of MRI-guided radiation, can eliminate tumors in people with locally advanced rectal cancer. The goal is to see if this approach is safe and can lead to a complete response, potentially avoiding the need for surgery. The study involves 25 participants and focuses on tracking side effects and tumor response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
5-fluorouracil (5-FU) chemotherapy and intensity-modulated radiation therapy (IMRT)
What this could lead to
If successful, this approach could allow some patients with locally advanced rectal cancer to avoid surgery by achieving a complete response through higher-dose radiation and chemotherapy.
What could go wrong
This is a very early phase 1 trial with only 25 participants, so safety and effectiveness are not yet proven. Higher radiation doses may increase side effects, and not all patients will achieve a complete response.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Miami
RECRUITINGMiami, Florida, 33136, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••