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Timing of chemo may boost rectal cancer remission

NCT ID NCT05054959

Ongoing Disease control Sponsor: Institute of Oncology Ljubljana Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This trial tests whether giving chemotherapy before or after radiation therapy works better for people with locally advanced rectal cancer that has a high risk of coming back. Participants receive the same drugs (capecitabine and oxaliplatin) but in a different order. The goal is to see which sequence leads to more complete remissions, where no cancer is found after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
CAPOX chemotherapy (capecitabine and oxaliplatin)
What this could lead to
If successful, this study could identify the best order of chemotherapy and radiation to increase the chance of complete tumor disappearance in high-risk rectal cancer.
What could go wrong
This is a small Phase 2 trial, so results may not apply broadly. Both chemotherapy sequences carry side effects like nerve damage, fatigue, and digestive issues.

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Conditions

The condition(s) this trial relates to.

rectal cancer rectal neoplasm rectum adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED RECTAL CANCER

Contacts and locations

Locations

  • Institute of Oncology

    Ljubljana, Slovenia, 1000, Slovenia

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