Could a Tumor's genes reveal who can skip chemo?
NCT ID NCT03573791
First seen Aug 18, 2026 · Last updated Aug 18, 2026
Summary
This study aims to find biomarkers in tumor tissue that can predict whether a patient with locally advanced rectal cancer will resist neoadjuvant chemoradiotherapy. About half of patients do not respond well to this treatment, and identifying these patients beforehand could help them avoid unnecessary therapy and go straight to surgery. Researchers will compare gene expression profiles between patients who respond completely and those who do not, using RNA sequencing. The study involves 152 participants with stage II-III rectal cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this could help doctors identify which rectal cancer patients will not benefit from chemoradiotherapy, allowing them to proceed directly to surgery and avoid unnecessary side effects.
- What could go wrong
- This is an early-stage biomarker discovery study, and the findings may not translate into a reliable clinical test. The results will need validation in larger, independent groups of patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hubei Cancer Hospital
NOT_YET_RECRUITINGWuhan, Hubei, 430079, China
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Wuhan Union Hospital
RECRUITINGWuhan, Hubei, 430022, China
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