RECTAL CANCER

This study tests whether adding the drug epacadostat to standard chemotherapy and radiation before surgery can improve outcomes for people with locally advanced rectal cancer. About 49 adults with stage 2 or 3 rectal cancer will take part. The goal is to find the best dose and se…

This study tests whether using a reinforcing material called SIS during bowel reconnection after rectal cancer surgery can prevent a serious complication called anastomotic leakage. About 966 adults with mid-to-low rectal cancer will be randomly assigned to receive either standar…

This study is for people with low rectal cancer that can be removed by surgery. Participants receive chemotherapy plus an immunotherapy drug (tislelizumab) before any surgery. If the tumor completely disappears after this treatment, they may avoid surgery and just be watched clos…

This study tests whether adding an immunotherapy drug (PD-1 inhibitor) to a standard treatment plan (short-course radiation, chemotherapy, and a targeted therapy) can improve outcomes for people with locally advanced rectal cancer. About 104 participants will receive the standard…

This study is for people with rectal cancer that didn't fully go away after standard chemotherapy and radiation. Instead of moving straight to surgery, doctors will give extra internal radiation (brachytherapy) directly to the remaining tumor. The goal is to see if this can compl…

This study looks at whether people with a certain type of rectal cancer (dMMR/MSI-H) can safely avoid surgery if their tumor disappears after immunotherapy. Standard treatments like surgery or chemo can cause lasting side effects, including loss of bowel control or needing a perm…

This study tests a treatment plan for people with stage II or III rectal cancer. Participants receive short-course radiation followed by several rounds of chemotherapy before any surgery. The goal is to see how many patients have their cancer completely disappear or shrink enough…

This study tests two different radiation schedules (short-course vs long-course) combined with an immunotherapy drug (Adebrelimab) and chemotherapy before surgery for people with locally advanced rectal cancer. The goal is to see which approach better shrinks or eliminates the tu…

This study tests whether giving chemotherapy alone before limited surgery works as well as chemotherapy plus radiation for early-stage rectal cancer. The goal is to see if skipping radiation can improve quality of life without harming cancer control. About 250 adults with early r…

This study tests whether adding an immunotherapy drug (pucotenlimab) to standard chemoradiation can help shrink advanced rectal cancers before surgery. About 68 adults with locally advanced rectal cancer will receive the combination treatment. The goal is to see if more patients …

This study tests whether a newer oral chemotherapy drug (TAS-102) works better than the current standard (capecitabine) when given with radiation before surgery for locally advanced rectal cancer. About 210 adults aged 18-75 with stage II or III rectal cancer will take part. The …

This early-stage study tests a new treatment using a patient's own immune cells, engineered to target a protein called CEA found on certain cancer cells. It is for adults with advanced lung, stomach, colon, rectal, esophageal, or pancreatic cancer who have not responded to standa…

This study is for people with a certain type of advanced rectal cancer called HER2-positive. Researchers are testing whether adding two targeted drugs, tucatinib and trastuzumab, to standard chemotherapy can shrink tumors more effectively before surgery or radiation. About 37 adu…

This study tests whether adding an immunotherapy drug (pucotenlimab) to standard chemotherapy (CAPOX) helps shrink tumors more before surgery in people with locally advanced rectal cancer. About 556 adults aged 18-75 will be randomly assigned to receive either the drug combo or c…

This early-phase trial tests a new way to give radiation therapy for locally advanced rectal cancer. The goal is to see if giving higher doses of radiation in a shorter time, along with chemotherapy, can shrink the tumor enough to avoid surgery. About 27 adults with stage T3-4 or…

This study tests whether a combination of chemotherapy and radiation before surgery (total neoadjuvant therapy) can help about half of rectal cancer patients achieve a complete response, allowing them to avoid surgery and preserve their rectum through a watch-and-wait strategy. T…

This study tests whether giving chemotherapy before surgery works better than giving it after surgery for people with locally advanced rectal cancer that has a low chance of coming back in the same area. About 550 adults will be randomly assigned to one of two groups. The goal is…

This study tests if a newer two-step surgery (Turnbull-Cutait) helps people with low rectal cancer avoid a permanent stoma (colostomy bag) better than standard surgery with a temporary stoma. About 520 adults with low rectal cancer will be randomly assigned to one of the two surg…

This phase 3 trial tests whether a stronger chemotherapy regimen plus a targeted drug (bevacizumab) can replace standard chemoradiation for high-risk locally advanced rectal cancer. About 582 adults will be randomly assigned to one of two treatments. The goal is to see if the new…

This study is for people with mid-to-low rectal cancer that has high-risk features. It compares two treatment plans: short-course radiation followed by chemotherapy plus an immunotherapy drug (toripalimab), with or without an additional anti-angiogenic drug (surufatinib). The goa…

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors (like colorectal, lung, or pancreatic cancer) that have lost a specific marker on their cells. The treatment uses the patient's own immune cells, modified to target cancer cells while protecti…

This early-phase trial tests a new drug called MDX2001 in people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. About 285 adults with various cancers like lung, breast, or colon cancer will take part.

This study tests whether giving a mix of immunotherapy (PD-1 blocker and IL-2) plus chemotherapy before surgery can shrink tumors more effectively in people with locally advanced rectal cancer. About 130 adults with a specific type of rectal cancer (MSS/pMMR) will take part. The …

This study tests a new way of giving three chemotherapy drugs (TAS-102, oxaliplatin, and irinotecan) along with a targeted therapy (bevacizumab) to people with advanced colorectal cancer that has stopped responding to standard treatments. The goal is to see if this combination ca…

This study tests whether taking sildenafil (Viagra) soon after rectal cancer surgery and radiation can prevent long-term erectile problems. About 188 men aged 18 to 70 with normal erectile function before treatment will take sildenafil or a placebo for 12 months. The goal is to s…

This study tests a new treatment for people with certain advanced cancers (like pancreatic, stomach, or colon cancer) that have a specific genetic change called KRAS G12V. The treatment involves taking a patient's own white blood cells, modifying them in a lab to better recognize…

This study tests whether a combination of two drugs, botensilimab and balstilimab, can clear remaining cancer DNA in people with colorectal cancer who still have signs of disease after surgery and chemotherapy. About 284 adults with a specific type of colorectal cancer (MSS) will…

This study tests whether adding a natural supplement (β-hydroxybutyrate) to a standard treatment plan can help shrink or eliminate rectal cancer before surgery. The plan includes short-course radiation, immunotherapy, and chemotherapy. The goal is to see if more patients achieve …

This study is for people with rectal cancer whose tumors completely disappear after initial chemotherapy and radiation. Instead of routine surgery, doctors will closely monitor them to see if the cancer stays away. The goal is to safely avoid major surgery and preserve the rectum…

This study tests whether giving a specific chemotherapy regimen (mFOLFOX) along with a short course of radiation before surgery can help people with rectal cancer live longer without the cancer coming back. About 54 adults with resectable rectal cancer will receive this treatment…

This study is testing whether adding leucine, a common amino acid found in food, to standard chemotherapy and radiation can help shrink tumors more effectively in people with locally advanced rectal cancer. About 33 adults will receive leucine alongside their usual treatment befo…

This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, breast, and kidney cancers) that have not responded to standard therapy. The treatment uses specially engineered immune cells designed to kill cancer cells while protectin…

This study tests whether chemotherapy alone works as well as chemotherapy followed by radiation for people with advanced rectal cancer that can be surgically removed. About 540 adults with mid or low rectal cancer will be randomly assigned to one of two treatment groups. The goal…

This study tests a device called CG-100 that is placed inside the bowel after rectal cancer surgery. The goal is to see if it can help the healing and reduce the need for a temporary or permanent stoma (a bag outside the body for waste). About 250 adults with rectal cancer who ar…

This study tests whether adding a special medical food that limits certain amino acids to standard cancer therapy is safe and doable for people with locally advanced rectal cancer. About 30 adults will receive the medical food alongside radiation and chemotherapy before surgery. …

This study tests a combination of two cancer drugs (fruquintinib and FOLFIRI) as a second treatment option for people with metastatic colorectal cancer whose first treatment stopped working. About 60 adults will receive the drug combo to see if it can slow cancer growth and how s…

This study tests a precise radiation method guided by MRI, combined with standard chemotherapy, for people with distal rectal cancer. The goal is to destroy the tumor and avoid major surgery, allowing patients to keep their rectum. About 100 participants will be enrolled to see i…

This study tests a new approach for people with early-stage rectal cancer that hasn't spread to lymph nodes. Instead of standard radiation to the whole pelvis, doctors give a short course of radiation only to the tumor, followed by chemotherapy and two types of immunotherapy. The…

This study is for people with early- or intermediate-risk low rectal cancer. It tests whether patients who respond well to chemotherapy and radiation can safely avoid surgery and instead be closely monitored (watch-and-wait). The goal is to preserve the rectum and improve quality…

This study tests a new treatment plan for people with locally advanced rectal cancer. Participants first get a short course of radiation along with an immune-boosting drug (IL-2). Then they receive chemotherapy (CAPOX) plus two immunotherapy drugs (a PD-1 antibody and IL-2). The …

This study tests a new endorectal device that combines ultrasound and photoacoustic imaging to better diagnose rectal cancer and assess how well tumors respond to treatment. About 90 adults with rectal cancer who are scheduled for surgery will be imaged with this device. The goal…

This study tests a new way to prevent low anterior resection syndrome (LARS) — bowel urgency, leakage, and frequency — after rectal cancer surgery. 160 participants with a temporary ileal stoma will receive either their own intestinal fluid or water infused through the stoma befo…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study tests a shorter course of radiation therapy to relieve symptoms like bleeding and pain in people with rectal cancer who cannot have surgery due to age, other health problems, or cancer spread. About 50 adults will receive 13 radiation treatments over a few weeks. Resea…

This study looks at whether a ketogenic (low-carb, high-fat) diet helps rectal cancer patients follow their diet plan during chemoradiation. About 194 people will be split into two groups: one gets a personalized keto diet, the other gets standard nutrition advice. The main goal …

This study tests whether an intensive follow-up program can improve bowel control and quality of life for people who have had rectal cancer surgery. About 140 adults who have bowel problems after surgery will either get the intensive program or standard care. The program includes…

This study tests whether placing probiotics into the unused part of the gut before stoma reversal surgery can improve bowel function in people treated for ultra-low rectal cancer. About 156 adults who had a temporary ileostomy will be randomly assigned to receive probiotics, a pl…

This study looks at whether adding fermented foods (like yogurt, kimchi, and sauerkraut) to the diet can improve quality of life and treatment response in people with rectal or lung cancer. About 54 participants will either eat these foods regularly or follow their usual diet. Re…

This study tests whether using virtual reality (VR) can reduce severe belly pain in people with digestive tract cancers. 360 participants will be split into three groups: one using skills-based VR, one using distraction VR, and a sham control group. Researchers will track pain, a…

This study tests if watching online interactive videos can improve bowel symptoms, emotional distress, and quality of life in people who have had rectal cancer. About 110 adults with stage I-III rectal cancer will participate. The videos are designed to teach coping strategies fo…

This study looks at whether a prehabilitation program (exercise and nutrition coaching) before surgery is practical for people with stage II or III rectal cancer. About 40 participants will either receive the program or usual care. The main goal is to see if enough people join an…

This study aims to learn more about how rectal cancer responds to standard treatments like chemoradiation and chemotherapy. Researchers will analyze participants' blood, tissue, and scans to see if these tests can predict whether the cancer improves, worsens, or stays the same. A…

This study is looking at tiny particles called exosomes in the blood of people with rectal cancer. The goal is to see if these particles can help predict how well a patient responds to chemotherapy and radiation before surgery. Researchers will compare exosome levels before, duri…

This study is building a model using patient data (like scans and gut bacteria) to see who responds so well to initial therapy that they might not need surgery. It involves 869 adults with stage II/III rectal cancer. The goal is to help doctors choose the best timing for surgery …

This study follows 150 rectal cancer patients to understand why some have lasting bowel problems after treatment. Researchers will track symptoms and quality of life for a year after surgery or active surveillance. The goal is to create personalized care plans that improve daily …

This study looks at 300 people with rectal cancer who are getting immunotherapy. Researchers want to see if special MRI scans and blood tests can tell the difference between real tumor growth and a harmless temporary reaction called pseudoprogression. The goal is to avoid stoppin…

This study is gathering information from about 999 people with rectal cancer who are treated with a special device called the MAASTRO HDR applicator. The goal is to learn how well this treatment works and what side effects it may cause, so doctors can improve future care. Partici…

This study follows 368 colorectal cancer survivors aged 25-65 to see how their quality of life changes 6, 12, and 24 months after treatment. Researchers will use questionnaires to measure physical, mental, and social well-being, and look for late side effects linked to their spec…

This early-phase study tests a special PET/CT scan that uses a modified tryptophan molecule to highlight tumors. Researchers want to see if this scan can better distinguish cancer from healthy tissue in people with brain tumors, breast cancer, neuroendocrine tumors, or rectal can…

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study collects blood and leftover tissue samples from 9,600 adults with different types of cancer, such as breast, lung, and pancreatic cancer. Researchers will use these samples to improve tests that look for tiny bits of cancer DNA in the blood, which may help detect if ca…

This study looks at whether keeping the left colic artery intact during surgery for colorectal or ovarian cancer helps maintain better blood flow to the colon. About 50 adults scheduled for left-sided colon, rectal, or ovarian cancer surgery will participate. Researchers will mea…

This study aims to develop a more accurate bowel diary for rectal cancer patients to track symptoms like bowel dysfunction after treatment. Researchers will work with 158 patients and experts to create and test a smartphone app-based diary. The goal is to better understand and ma…

This study tests whether daily CT scans can help doctors see and protect the ovaries during pelvic radiation in women under 50 with various cancers. The goal is to keep radiation doses to the ovaries low enough to avoid early menopause and infertility. Ten participants will recei…

This study is testing whether an artificial intelligence (AI) system can analyze MRI scans to predict how well rectal cancer responds to chemotherapy and radiation before surgery. About 1,700 adults with advanced rectal cancer will have their scans reviewed by the AI to see if it…

This study looks at whether a special type of MRI, called amide proton transfer-weighted imaging, can accurately predict if rectal cancer has completely disappeared after chemotherapy and radiation. Researchers will scan 320 people before surgery and compare the scan results to t…

This study looks at whether adding a geriatrician (a doctor who specializes in care for older adults) to the cancer care team helps people aged 70 and older with gastrointestinal cancers. Researchers want to see if this approach is practical and if it reduces unplanned hospital v…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…