RECTAL CANCER

This study looked at 91 adults with rectal cancer who needed pelvic floor reconstruction after surgery. It compared using a biological mesh made from pig collagen versus using a muscle flap from the buttock. The goal was to see which method leads to better physical function six m…

This study tested a treatment plan for people with locally advanced rectal cancer. Instead of the usual surgery, patients received a short course of radiation followed by chemotherapy. The goal was to see if this approach could lead to a complete response that lasts over a year, …

This early-phase trial tested a new treatment for people with advanced cancers (like pancreatic, stomach, or colon cancer) that have a specific genetic change called KRAS G12D. Doctors took participants' own white blood cells, modified them in a lab to better recognize and attack…

This study tested an experimental drug called CTX-009 in 49 adults with metastatic colorectal cancer that had worsened after two or three prior treatments. The goal was to see if the drug could shrink tumors or stop cancer growth. Participants received CTX-009 and were monitored …

This study tested whether adding two months of chemotherapy (Folfirinox) before the usual radiation and chemo could help more people with early-stage rectal cancer keep their rectum instead of needing surgery. 218 adults with small, low-lying tumors took part. The goal was to see…

This study tested a shorter course of radiation followed by a chemotherapy combination (TASOX) in 13 people with intermediate-risk rectal cancer. The goal was to shrink tumors before surgery. Results showed the treatment was safe and helped reduce tumor stage, allowing for succes…

This study tested whether adding immunotherapy to standard chemoradiation helps people with a specific type of ultra-low rectal cancer (MSS type) achieve a complete response, meaning no cancer remains. 201 patients who wanted to avoid permanent colostomy participated. The goal wa…

This study tested whether chemotherapy followed by a less invasive surgery could help people with early rectal cancer avoid major surgery and keep their rectum. 58 patients took part. The goal was to see if at least 65% could avoid removing the entire rectum. The approach aims to…

This study tested whether adding metformin, a common diabetes drug, to standard chemo-radiation before surgery could improve outcomes for people with locally advanced rectal cancer. 60 participants received the combination treatment. The main goal was to see if the cancer complet…

This study compared two types of surgery for low rectal cancer: a newer method that operates through the anus (transanal) versus the standard laparoscopic approach through the abdomen. 226 adults with non-spread rectal cancer took part. The goal was to see if the newer method is …

This study tested a new blood test designed to find colorectal cancer early in people at average risk. Nearly 49,000 adults aged 45 to 85 gave a blood sample before their routine colonoscopy. The goal was to see how well the blood test could detect cancer and advanced growths com…

This study tested two standard pain control methods after colon or rectal surgery: a local anesthetic delivered through small tubes placed near the surgical site (preperitoneal) versus an epidural. Researchers measured pain scores and the need for extra pain medication in 98 adul…

This study tested a personalized rehabilitation program for 150 adults who finished treatment for colorectal cancer. The program connects patients with specialists like physiotherapists, dietitians, and psychologists based on their individual needs. The goal was to improve qualit…

This study looked at 200 adults having elective colorectal surgery for colon cancer, rectal cancer, or diverticulosis. It compared two pain management methods: a TAP block (an injection into the abdominal wall) versus epidural anesthesia. The goal was to see which method provides…

This study tested a simple bladder training method called ICCAUT in 400 people who had rectal cancer surgery. The method involves clamping the urinary tube (catheter) and encouraging patients to actively urinate before removing it. The goal was to see if this reduces problems lik…

This study looked at 70 adults with colorectal cancer to see how common muscle loss (sarcopenia) is before surgery and whether it leads to more complications or longer hospital stays. Researchers measured muscle strength, mass, and physical performance. The goal was to find high-…

This study looked at 60 adults with a type of rectal cancer to see if the bacteria in their gut and mouth could predict how well their cancer responds to chemotherapy and radiation. Researchers collected stool and saliva samples before treatment and used machine learning to analy…

This study looked at 65 people who had rectal cancer surgery followed by a second surgery to reconnect the bowel. Researchers measured symptoms and quality of life one year after the second surgery using a standard questionnaire. The goal was to understand common bowel problems a…

This study tested whether checking the removed tissue during surgery (called frozen section) helps ensure all cancer is removed in people with mid or low rectal cancer who had radiation first. About 99 adults took part. Half had the extra tissue check during surgery, and half had…

This study tested a new way to predict whether immunotherapy before surgery will work for people with stomach or rectal cancer. Researchers used epigenetics (how genes are turned on or off) to build a prediction model. 189 participants were involved, and the goal was to see if th…

This study tested a new way to monitor patients after rectal surgery for leaks where the bowel is reconnected. A small probe was placed near the surgical connection to measure chemicals in the tissue. The goal was to see if this method could spot leaks earlier than standard tests…

This study looked at 89 people with rectal or lower colon cancer to see how blood flow changes after a common surgical step called high ligation. Doctors used special CT scans before and after surgery to map blood vessels and check if their planned paths matched reality. The goal…

This study looked at 57 people with rectal cancer who had surgery. Some had chemotherapy and radiation before surgery (RAPIDO protocol), some had only radiation, and some had surgery first. The goal was to see how these different approaches affected surgery time, blood loss, and …

This study looked at 3500 rectal cancer patients who had minimally invasive surgery to save their sphincter. Researchers tested seven different computer models, including six machine learning methods, to see which best predicts a condition called low anterior resection syndrome (…

This study tested whether a new type of PET scan (FAPI-PET/CT) can accurately predict if rectal cancer has completely disappeared after chemoradiotherapy. 52 patients with a specific type of rectal cancer (MSS) were scanned before surgery, and the results were compared to the act…

This study tested a special scope called LUMENEYE to see if it can better measure how well rectal cancer responds to chemotherapy and radiation. 82 patients who were good candidates for organ preservation took part. The goal was to see if the scope could accurately identify compl…

This study followed 107 adults newly diagnosed with rectal cancer to understand how their symptoms, balance, and quality of life change over time. Researchers used questionnaires to track bowel function, emotional distress, and balance ability. The goal was to learn more about pa…

This study looked at whether a special MRI measurement (T1 relaxation time) can tell if rectal cancer has been completely replaced by scar tissue after standard treatment. 44 adults with locally advanced rectal cancer had MRI scans before and after chemoradiation. The goal was to…

This study tested a 12-week web-based diet program with text messaging for 50 colorectal cancer survivors. The goal was to see if the program was easy to use and could help people eat more vegetables, whole grains, and fish while cutting back on red meat and sweets. Participants …

This study enrolled 60 Spanish-speaking Latino adults from a church in Chapel Hill to see if an educational session could improve their knowledge of colorectal cancer and willingness to join cancer clinical trials. Participants watched videos in Spanish and completed questionnair…