Engineered immune cells take aim at Hard-to-Treat cancers
NCT ID NCT05538195
First seen Jul 10, 2026 · Last updated Jul 10, 2026
Summary
This trial investigates a type of immunotherapy called CAR-T cells that are designed to recognize and attack cancer cells carrying a protein called CEA. The study includes adults with advanced gastric, colon, rectal, esophageal, or pancreatic cancer who have not responded to at least two prior standard treatments. Participants receive the CAR-T cells either through an IV or directly into the abdomen, along with chemotherapy to prepare the body. The goal is to assess safety, find the best dose, and measure how well the treatment controls the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CEA-targeted CAR-T cells
- What this could lead to
- If successful, this could offer a new treatment option for people with advanced solid tumors that express CEA and have not responded to standard therapies.
- What could go wrong
- This is an early-phase trial with a small number of participants. CAR-T therapy can cause severe side effects, and it is not yet known if it will effectively control these cancers.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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He'nan Cancer Hospital
Henan, China
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