RECTAL CANCER

This study is testing a multi-step treatment plan for people with locally advanced rectal cancer, aiming to shrink tumors before surgery. It combines a short course of radiation with two immunotherapy drugs (PD-1 antibody and IL-2) and a chemotherapy regimen (CAPOX). The main goa…

This study is testing whether adding two targeted drugs (tucatinib and trastuzumab) to standard chemotherapy before surgery can help shrink tumors in people with a specific type of rectal cancer (HER2-positive). The main goal is to see if this combination leads to a complete disa…

This study is testing whether using a special reinforcing patch made from pig intestine during rectal cancer surgery can prevent a serious complication called an anastomotic leak. Researchers will compare the patch to standard surgery in 966 patients across multiple hospitals in …

This study is testing whether a special high-fat, low-carbohydrate diet (ketogenic diet) helps rectal cancer patients better tolerate their radiation and chemotherapy treatment. Researchers will compare patients on this special diet to patients following standard nutrition guidel…

This study is comparing two treatment strategies for people with a specific type of rectal cancer that has a low risk of returning in the pelvis. The goal is to see if giving a 3-month course of chemotherapy before surgery is better than having surgery first followed by chemother…

This study is testing whether a targeted internal radiation treatment can help rectal cancer patients avoid surgery. It is for adults whose cancer did not fully disappear after standard chemotherapy and radiation. The goal is to see if this extra treatment can eliminate the remai…

This study is comparing two different surgical techniques for patients with low rectal cancer. The main goal is to see if a newer, two-stage surgery (TCA) results in more patients living for 3 years without needing a permanent stoma (ostomy bag) compared to the standard surgery (…

This study is testing whether a three-month course of strong chemotherapy before surgery works as well as the current standard approach of chemotherapy followed by radiation for locally advanced rectal cancer. It will involve 540 patients across France who have rectal cancer that…

This study is testing a new combination of four cancer drugs for people with advanced colorectal cancer that has continued to grow despite previous treatments. The goal is to see if this alternating drug schedule can stop or slow the cancer's progression. About 50 participants wi…

This study is testing whether precise, MRI-guided radiation treatment can help rectal cancer patients avoid major surgery to remove their rectum. The goal is to preserve normal bowel function while still effectively treating the cancer. Patients will receive this targeted radiati…

This study is testing whether a new, precise radiation planning technique can protect the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine or rectal cancer. The goal is to prevent radiation from causing early menopause, which can lead to ser…

This study is testing whether some patients with early-to-intermediate stage rectal cancer can safely avoid major surgery. If patients respond very well to initial chemotherapy and follow-up radiation/chemo, doctors will closely monitor them instead of operating immediately. The …

This large trial is comparing two treatment strategies for high-risk rectal cancer that hasn't spread. One group gets a very strong combination of chemotherapy drugs, hoping to avoid radiation and its long-term side effects like pain and incontinence. The other group gets the cur…

This study is testing whether a combination of two immunotherapy drugs can help prevent colorectal cancer from coming back in patients who have already had surgery and chemotherapy. The treatment is for people who still have tiny traces of cancer DNA in their blood after standard…

This study is testing whether adding the drug fruquintinib to a standard chemotherapy regimen (FOLFIRI) can better control advanced colorectal cancer that has spread. It is for people whose cancer has worsened after their first treatment. The main goals are to see if this combina…

This trial is testing a new treatment approach for early-stage rectal cancer. It combines a short, targeted course of radiation with oral chemotherapy and two immunotherapy drugs. The main goal is to see if this combination can completely eliminate the tumor, allowing more patien…

This study is testing a temporary internal device called CG-100, designed to help patients avoid getting a permanent stoma bag after rectal cancer surgery. Currently, many patients receive a stoma 'just in case' of complications, but most don't actually need it. The device acts a…

This study is testing if adding an experimental drug called epacadostat to the standard pre-surgery treatment (chemotherapy and radiation) works better for people with locally advanced rectal cancer. The main goals are to find the safest dose of the new combination and to see if …

This early-stage study is testing a new type of treatment called CAR-T cell therapy for people with advanced cancers that have a specific marker (CEA) and have stopped responding to standard treatments like chemotherapy. The main goals are to find a safe dose and see if the treat…

This trial is testing a new type of gene therapy for people with advanced pancreatic, colon, and other cancers that have a specific genetic change called KRAS G12V. Doctors take a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer c…

This study is testing a new type of cell therapy called A2B395 for adults with advanced solid tumors that have spread or returned. The therapy uses modified immune cells designed to specifically kill cancer cells while protecting the patient's healthy cells. The main goals are to…

This study is testing if adding a common amino acid called leucine to the standard pre-surgery treatment (chemotherapy and radiation) can help shrink tumors more effectively in people with locally advanced rectal cancer. The goal is to see if this combination leads to better outc…

This study is testing whether eating more fermented foods like yogurt, kimchi, and kombucha can help people with rectal or lung cancer. Researchers want to see if this special diet makes standard cancer treatments like chemotherapy and immunotherapy work better. They will also ch…

This study is testing whether a shorter, more intense course of radiation is as good as a longer, standard course when both are combined with a new immunotherapy drug and chemotherapy. The goal is to shrink tumors before surgery in people with locally advanced rectal cancer that …

This study is testing if patients with a specific type of rectal cancer can safely avoid major surgery after their cancer disappears with immunotherapy. Researchers want to see if close monitoring, called 'watch and wait,' is a safe option for these patients. The goal is to help …

This study is testing if a special medical food that restricts certain building blocks (nonessential amino acids) is safe, tolerable, and practical for patients to use. It will be given alongside the standard treatment plan of radiation and chemotherapy for locally advanced recta…

This study compares two treatment approaches for early rectal cancer. One group receives chemotherapy alone before limited surgery, while the other receives both chemotherapy and radiation therapy before surgery. Researchers want to see if both approaches work equally well at shr…

This study is testing whether adding a new immunotherapy drug called pucotenlimab to the standard pre-surgery treatment (chemotherapy and radiation) works better for people with locally advanced rectal cancer. The goal is to see if this combination helps more patients achieve a c…

This study is testing a new combination of treatments for people with locally advanced rectal cancer. The goal is to see if adding an immunotherapy drug to a standard mix of radiation, chemotherapy, and a targeted drug can better shrink tumors before surgery. Researchers will com…

This study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have come back or spread. The therapy, called Tmod CAR T, is designed to recognize and kill cancer cells while using a built-in safety switch to protect the patient's healthy …

This study is testing a combination of chemotherapy and short-course radiation given before surgery for rectal cancer. The goal is to better control the cancer and improve survival rates. Some participants who respond very well may avoid surgery altogether and instead be closely …

This study is testing if a new combination of immunotherapy drugs (tislelizumab and interleukin-2) plus standard chemotherapy works better than chemotherapy alone when given before surgery for locally advanced rectal cancer. The goal is to see if this approach shrinks tumors more…

This study is testing whether some rectal cancer patients can safely avoid major surgery. It focuses on 200 patients whose tumors disappear completely after initial chemotherapy and radiation. Instead of surgery, patients will enter a closely monitored follow-up program to see if…

This study is testing whether a special exercise and nutrition program before surgery helps people with rectal cancer. About 40 participants will be randomly assigned to either follow this 'prehabilitation' program or receive usual care. The main goal is to see if the program is …

This study aims to help doctors better tell the difference between real cancer growth and temporary inflammation that looks like growth during immunotherapy for rectal cancer. Researchers will use multiple MRI scans and blood tests from 300 patients to create a more accurate dete…

This early-stage study is testing a new imaging tracer to see if it can help doctors better tell the difference between cancer and normal tissue on a PET/CT scan. Researchers will give the tracer to 24 adults with specific cancers, including brain, breast, and rectal tumors, to s…

This study is testing a new imaging device that combines ultrasound and light to create detailed pictures of rectal tumors. The goal is to help doctors more accurately tell which patients have no cancer left after initial treatment and can safely avoid major surgery. About 90 pat…

This study is testing a new digital camera scope called LUMENEYE to see if it can better check how well rectal cancer tumors shrink after patients receive chemotherapy and radiation. The goal is to improve how doctors decide which patients might safely avoid having their rectum s…

This study is testing a special type of MRI scan to see if it can accurately tell whether a patient's rectal cancer has been completely eliminated by their initial treatment (chemotherapy/radiation) before they have surgery. The goal is to help doctors better decide which patient…

This study is looking at a short, 13-session radiation treatment for patients with rectal cancer who cannot have surgery. The goal is to see how well it reduces symptoms like pain and bleeding, and to monitor side effects. It involves 50 patients who are not candidates for surger…

This study is testing whether virtual reality (VR) can help reduce pain and improve quality of life for people with gastrointestinal cancers. Researchers will compare three approaches: VR that teaches pain management skills, VR designed to distract from pain, and a basic VR contr…

This study is testing whether specially designed online interactive videos can help people who have had surgery for rectal cancer. It aims to see if these videos can improve common post-surgery bowel problems (known as LARS), reduce psychological distress, and boost overall quali…

This study is testing whether placing probiotic pills directly into the intestine during a temporary stoma (ileostomy) can help patients regain better bowel control after the stoma is reversed. It involves 156 patients who have had surgery for very low rectal cancer. Researchers …

This study is testing if surgeons can safely preserve a specific artery (the left colic artery) during surgery for colon, rectal, or ovarian cancer. The goal is to see if keeping this artery open provides better blood flow to the remaining colon, which could help it heal better a…

This large international study is collecting information on a new, more precise type of radiation therapy that uses real-time MRI scans to guide treatment. It aims to see if this advanced technology helps people with many types of cancer live longer, better control their tumors, …

This study aims to better understand how rectal cancer patients respond to standard chemotherapy and radiation treatments. Researchers will analyze participants' blood, tissue samples, and medical scans to learn how cancers change during treatment. The goal is to find patterns th…

This study aims to collect blood and tissue samples from people with various cancers to help develop better blood tests. Researchers want to see if these tests can detect tiny amounts of leftover cancer cells after treatment, which might help predict if the cancer could return. P…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This study aims to understand why many rectal cancer patients continue to experience bowel problems long after their treatment ends. Researchers will follow 150 patients for 12 months after surgery or other treatments to identify factors that predict these persistent symptoms. Th…

This study aims to understand how colorectal cancer survivors feel and function in the years after their treatment ends. Researchers will follow 368 working-age survivors for up to 2 years, checking in at 6, 12, and 24 months. The goal is to identify common long-term side effects…