RECTAL CANCER

This study is investigating whether a combination of radiation and chemotherapy alone can cure low rectal cancer, potentially allowing patients to avoid major surgery. It follows 108 patients to see if their tumors are controlled two years after finishing this non-surgical treatm…

This early-stage study is testing a new oral drug, GSK4418959, for adults with advanced solid tumors that have specific genetic features (called dMMR or MSI-H). The main goals are to find a safe dose, see how the body processes the drug, and check if it can shrink tumors, either …

This study tested whether giving strong chemotherapy before surgery and radiation could help shrink aggressive rectal tumors and make them easier to remove completely. It involved 40 adults with high-risk rectal cancer that hadn't spread to distant organs. The goal was to see if …

This study is testing whether adding an immunotherapy drug called nivolumab to the standard pre-surgery treatment (chemotherapy and radiation) works better for people with locally advanced rectal cancer. The goal is to see if this combination helps eliminate more of the cancer be…

This study is testing if adding a more intensive chemotherapy combination (called FOLFOXIRI) to the standard pre-surgery treatment can better shrink aggressive rectal tumors. It involves 72 adults with high-risk, locally advanced rectal cancer that hasn't spread to distant organs…

This study is testing whether using a Fitbit and a mobile app can help patients recover better after major surgery for gastrointestinal cancers. About 107 patients were randomly assigned to either use the app and tracker along with their usual care, or to receive usual care alone…

This study compares two treatment approaches given before surgery for locally advanced rectal cancer. One group receives a shorter course of radiation followed by chemotherapy and an immunotherapy drug (camrelizumab). The other group receives the standard longer course of radiati…

This study is testing whether a combination of two drugs, cabozantinib and nivolumab, can help control advanced colorectal cancer that has stopped responding to standard treatments. It will involve about 48 adults whose cancer has spread and is a specific type called microsatelli…

This study is testing whether adding a new immunotherapy drug (tiragolumab) to an existing one (atezolizumab) can help eliminate rectal cancer more effectively after patients receive standard chemoradiation. The goal is to see if the drugs can destroy all cancer cells in the remo…

This study is testing whether a 12-week aerobic exercise program can help prevent cancer from coming back in people who have finished treatment for colon or rectal cancer. Researchers will measure changes in blood markers related to inflammation and cancer cells. The goal is to u…

This study is testing a new treatment plan for rectal cancer that hasn't spread to distant organs. It compares a shorter course of radiation followed by four cycles of chemotherapy (FOLFOX) against the standard longer chemoradiation, both given before surgery. The goal is to see …

This study is testing whether a modified surgical stitching method is safer than the current standard technique for patients having minimally invasive rectal cancer surgery. Researchers want to see if the new method reduces the risk of dangerous leaks where the bowel is reconnect…

This study is testing a new treatment approach for people with locally advanced rectal cancer. Before surgery, patients receive a combination of standard chemotherapy and an immunotherapy drug called sintilimab. The goal is to see if this combination can effectively shrink the tu…

This study aimed to test if a combination of two drugs, regorafenib and lorigerlimab, could shrink rectal cancer tumors that had started to grow back or returned locally after a patient's first round of treatment. The goal was to see if this drug combo could reduce the cancer eno…

This is a small, early-stage study to test a new type of imaging scan. The scan uses a special radioactive tracer that attaches to a protein (CEA) made by many cancers. The goal is to see if this new scan can find cancer spots that standard imaging tests might miss in patients wi…

This study aims to understand how treatment affects the daily lives and well-being of people with recurrent rectal cancer. Researchers will ask 116 participants to complete questionnaires about their symptoms, expectations, and quality of life every six months for up to five year…

This study aims to discover new types of inherited gene changes that might explain why some people develop cancer. Researchers are studying cancer patients along with their unaffected parents to look for gene differences that appear in the child but not the parents. The goal is t…