RECTAL CANCER

This study looks at whether a combination of radiation and chemotherapy can cure low rectal cancer, allowing patients to avoid surgery. About 108 people with early-stage rectal tumors near the anus will receive this treatment. The main goal is to see if the cancer stays under con…

This Phase III trial tests whether a modified short-course radiation that spares nearby lymph nodes, combined with chemotherapy (CAPOX) and the immunotherapy drug tislelizumab, works better than standard radiation plus chemotherapy for people with a certain type of rectal cancer …

This phase 3 trial studies whether adding pelvic reirradiation to chemotherapy before surgery can help more patients with locally recurrent rectal cancer achieve complete tumor removal. The study enrolls 58 adults who have had prior pelvic radiation and now face a recurrence. Par…

This study tests four different tools—coaching, education, text messages, and health coaching—to help cancer survivors improve their diet, physical activity, and weight. About 350 adults who have completed treatment for several cancer types will use these tools for up to 48 weeks…

This early phase trial tests a biological product mix designed to train the immune system to recognize and kill CEA-positive rectal cancer cells. The study involves 20 participants with early-stage rectal cancer (Stage 0 to IIA) who have not yet developed symptoms or metastasis. …

This study tests whether eating 3-6 servings of fermented foods daily (like yogurt, kefir, and sauerkraut) can improve how well cancer treatments work in patients with locally advanced rectal cancer or non-small cell lung cancer. The 39 participants are randomly assigned to eithe…

This study tests a treatment plan to avoid major surgery for early-stage rectal cancer. Patients first receive chemotherapy, then a small surgery to remove the tumor, followed by radiation and more chemo. The goal is to see if this approach can cure the cancer while keeping the r…

This phase 3 trial compares two treatment approaches for high-risk rectal cancer. The experimental group gets a short course of radiation (5 days) followed by several months of chemotherapy before surgery. The standard group receives longer chemoradiotherapy followed by surgery a…

This study tests whether giving a higher, targeted radiation dose to the main tumor and nearby lymph nodes can improve outcomes for people with locally advanced rectal cancer. About 128 adults whose cancer has not spread beyond the pelvis will receive either standard radiation or…

This pilot study tests a new rectal applicator for delivering radiation therapy to elderly patients with inoperable rectal cancer. The treatment combines external beam radiation with three sessions of internal radiation (brachytherapy) using the new device. The study aims to see …

This study tests whether adding two immunotherapy drugs (atezolizumab and tiragolumab) after standard chemoradiation can help eliminate tumors in people with locally advanced rectal cancer. About 58 participants will receive either the drug combination or atezolizumab alone befor…

This study tests a new surgical technique called transanal total mesorectal excision (taTME) for rectal cancer. Instead of operating from the abdomen, surgeons work from the anus upward, which may make it easier to remove the tumor completely. The trial includes 100 adults with e…

This phase 2 trial is testing a combination of two drugs, cabozantinib and nivolumab, in 48 people with advanced colorectal cancer that has not responded to standard treatments. The goal is to see if the combination can shrink or stabilize tumors. All participants have a type of …

This Phase 3 trial tests whether a short course of radiotherapy followed by the immunotherapy drug camrelizumab plus chemotherapy works better than standard long-term chemoradiation for locally advanced rectal cancer. About 230 patients will be randomly assigned to one of the two…

This study planned to test two drugs—regorafenib (a pill) and lorigerlimab (given by IV)—in people whose rectal cancer had come back or grown after standard treatment. The goal was to see if the combination was safe and effective. However, the trial was withdrawn before enrolling…

This Phase 2 trial tests a shorter course of radiation followed by FOLFOX chemotherapy before surgery for locally advanced rectal cancer. About 364 participants will be randomly assigned to either this new regimen or standard chemoradiation. The goal is to see if the shorter appr…

This early-phase study tests an experimental oral drug (GSK4418959) in adults with advanced solid tumors that have specific genetic changes (dMMR or MSI-H). The drug works by blocking a protein (WRN) that these tumors need to survive. The study aims to see if the drug, alone or w…

This trial tests a modified stapling technique (MST) against the standard method in 450 adults having minimally invasive rectal cancer surgery. The goal is to see if MST reduces the chance of anastomotic leaks, a serious complication. Participants will be randomly assigned to one…

This study tests whether giving immunotherapy before surgery can help people with MSI/dMMR tumors. The goal is to shrink or eliminate the tumor before it is removed, potentially improving survival. The trial includes adults with localized, resectable cancers such as colorectal, g…

This phase 2 trial tests whether adding the immunotherapy drug nivolumab (Opdivo) to standard chemoradiation and chemotherapy can improve outcomes for people with locally advanced rectal cancer. About 29 participants who have not had prior treatment will receive chemoradiation, t…

This study tests whether a combination of chemotherapy and an immunotherapy drug (sintilimab) can effectively treat locally advanced rectal cancer without the need for radiation. The goal is to shrink or eliminate tumors before surgery, potentially preserving organ function. The …

This phase 2 trial tests a two-step approach for high-risk rectal cancer: first, a strong chemotherapy cocktail (FOLFOXIRI), followed by radiation combined with a chemo pill (capecitabine). The goal is to shrink tumors before surgery, making them easier to remove. The study invol…

This phase 2 trial tests whether adding a stronger chemotherapy regimen (FOLFOXIRI) before the usual chemoradiation and surgery can improve outcomes for people with high-risk locally advanced rectal cancer. About 72 participants will be randomly assigned to either standard treatm…

This study looks at whether a special drink made with easily digested protein and MCT oil can help improve malnutrition in cancer patients who are having radiotherapy. The study will follow 132 adults with head and neck, lung, rectal, or esophageal cancer for 12 weeks. Researcher…

This study tests a special PET scan that uses a radioactive antibody (64Cu-M5A) to find cancers that produce a protein called CEA. The goal is to see if this scan can detect tumors that standard methods might miss. About 20 adults with CEA-positive cancers (such as breast, colon,…

This study tests whether taking two drugs, eflornithine and sulindac, together can lower the chance of new high-risk growths or a second colon cancer in people who have already had stage 0 to III colon or rectal cancer. About 350 participants who are cancer-free after surgery wil…

This study tests whether transanal irrigation (using water to flush the bowel) can improve quality of life and reduce bowel symptoms in 66 rectal cancer survivors who have low anterior resection syndrome (LARS). Participants learn the technique through an online platform with vir…

This study tests whether adding a single, non-invasive biofeedback session to home Kegel exercises can improve bowel control, reduce emotional distress, and enhance quality of life in people who have had rectal cancer surgery. About 66 participants will be randomly assigned to ei…

This study tests a program that lets cancer patients receive care at home while undergoing chemotherapy or radiation. It includes remote monitoring and home visits to reduce the need for hospital stays or emergency room visits. The goal is to see if this approach improves quality…

This study tests whether a 6-week online program based on Acceptance and Commitment Therapy (ACT) can help cancer survivors who have finished treatment feel less anxious and depressed. 32 survivors of breast, colon, or rectal cancer will be randomly assigned to either the online …

This study tests whether using a FitBit and a mobile app can help people recover at home after surgery for stomach, liver, colon, or other GI cancers. About 107 patients will either use the devices plus standard care, or standard care alone. The app tracks activity and symptoms, …

This study tests a program that combines pelvic floor physical therapy with coping skills training to help women who have had pelvic radiation for cancer. The goal is to improve sexual function and quality of life. The study involves 12 cancer survivors and focuses on whether the…

This study tests whether a new type of adaptive radiotherapy can reduce radiation exposure to the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine, rectal, or cervical cancer. Using advanced imaging and an AI treatment planning system, resea…

This study aims to identify which of four French-validated questionnaires is most suitable for assessing sexual function in women who have had surgery for rectal or recto-sigmoid cancer. Researchers will ask 50 women to complete all four questionnaires and rank their preferences.…

This study planned to look back at MRI scans of people with rectal cancer to see if the images could predict how aggressive the cancer is and how well it responds to treatment. The goal was to create a computer model to help doctors make better decisions. However, the study was w…

This study tests whether AI-generated messages can change how cancer survivors think about alcohol and cancer risk. About 850 adults who have had certain cancers and currently drink alcohol will view different messages. Researchers will measure changes in their beliefs about canc…

This study tests whether a simple blood test that looks for tumor DNA can detect colorectal cancer coming back earlier than standard CT scans. About 359 people who had surgery for stage II or III colorectal cancer will be randomly assigned to either the blood test plus frequent P…

This study follows 116 people with recurrent rectal cancer to understand how their treatment affects their quality of life and well-being. Participants fill out questionnaires every 3 months about their symptoms, daily activities, and overall health. The goal is to learn what mat…

This study searches for new gene changes (mutations) that appear in cancer patients but not in their healthy parents. By comparing DNA from 1,275 people with certain cancers and their families, researchers hope to find genetic clues that increase cancer risk. The goal is to bette…

This study looks at how moderate aerobic exercise (like brisk walking) might help prevent colorectal cancer from coming back. Researchers will measure changes in inflammation and other blood markers in 60 people who have finished cancer treatment. Participants either walk on a tr…