RECTAL CANCER

This study looks at whether a combination of radiation and chemotherapy can cure low rectal cancer, allowing patients to avoid surgery. About 108 people with early-stage rectal tumors will receive this treatment and be followed for two years to see if the cancer stays away. The g…

This study tests a combination of two drugs, cabozantinib and nivolumab, in people with advanced colorectal cancer that has not responded to standard treatments. The goal is to see if the combination can stop or shrink the cancer for at least 16 weeks. About 48 adults with a spec…

This study tested a powerful chemotherapy combination (FOLFOXIRI) followed by radiation with capecitabine before surgery in 40 people with high-risk rectal cancer. The goal was to shrink tumors and make surgery more successful. The approach aims to control the disease and reduce …

This study tests whether adding two immunotherapy drugs (atezolizumab and tiragolumab) after standard chemoradiation can help eliminate rectal cancer in people with locally advanced disease. About 58 adults with resectable rectal cancer will receive either the drug combination or…

This study tests whether adding a stronger chemotherapy regimen (FOLFOXIRI) to standard chemoradiation before surgery can improve outcomes for people with high-risk locally advanced rectal cancer. About 72 participants will be randomly assigned to receive either standard treatmen…

This study tests whether giving a higher, precisely targeted radiation dose to the main tumor and nearby lymph nodes can improve outcomes for people with locally advanced rectal cancer. About 128 participants will receive either standard radiation or this adaptive boost approach …

This study compares a new stapling method (MST) to the standard method (DST) for reconnecting the bowel after rectal cancer surgery. The goal is to see if MST lowers the chance of a leak at the connection site, which can cause serious problems. About 450 adults having minimally i…

This study tests a new, already-approved device for delivering internal radiation (brachytherapy) to treat rectal cancer in elderly patients who cannot undergo surgery. The goal is to see if the new device works as well as the current one while being more comfortable and faster. …

This phase 3 trial tests whether a short course of radiation followed by immunotherapy (camrelizumab) and chemotherapy can completely eliminate rectal cancer before surgery. About 230 adults with locally advanced rectal cancer will be randomly assigned to this new approach or sta…

This study tests whether a combination of chemotherapy and an immunotherapy drug (sintilimab) can effectively treat locally advanced rectal cancer without using radiation. About 50 patients with a specific genetic profile (pMMR/MSS) will receive this treatment before surgery. The…

This study tests a shorter course of radiation followed by 4 cycles of FOLFOX chemotherapy before surgery for locally advanced rectal cancer. The goal is to see if this approach improves 3-year disease-free survival compared to standard chemoradiation. About 364 Asian adults with…

This study was designed to test two drugs, regorafenib and lorigerlimab, in people whose rectal cancer had come back or was growing after initial treatment. The goal was to see if the combination was safe and effective. However, the trial was withdrawn before enrolling any partic…

This study compares two treatment approaches for people with high-risk rectal cancer. The experimental group gets a short course of radiation (5 days) followed by several weeks of chemotherapy before surgery, while the standard group gets the usual longer radiation with chemo. Th…

This study tests an experimental oral drug (GSK4418959) in adults with advanced solid tumors that have specific genetic features (dMMR or MSI-H). The drug aims to shrink tumors by blocking a DNA repair protein. The trial will check safety, side effects, and how well the drug work…

This study tests a new surgical technique called taTME for rectal cancer, where doctors remove the tumor from the bottom up using a scope through the anus. It aims to improve surgical quality and reduce complications compared to standard laparoscopic or robotic methods. The study…

This study tests whether adding the immunotherapy drug nivolumab to standard chemotherapy and radiation can improve outcomes for people with locally advanced rectal cancer. About 29 participants who have not had prior treatment will receive the combination before surgery. The mai…

This study tests a special PET scan that uses a radioactive antibody (64Cu-M5A) to find cancers that produce a protein called CEA. About 20 adults with various CEA-positive cancers will receive the injection and have scans over two days. The goal is to see if this method can dete…

This study looks at whether adding one non-invasive biofeedback session to regular Kegel exercises can improve bowel function, reduce emotional distress, and boost quality of life in people who have had rectal cancer surgery. About 66 participants will either do Kegel exercises a…

This study tests whether using a FitBit and a mobile app can help people who have had surgery for stomach, liver, colon, or other GI cancers avoid going back to the hospital. About 107 adults who own a smartphone and are scheduled for surgery will either use the devices or get us…

This study tests a program that lets cancer patients receive care at home through remote monitoring during chemotherapy or radiation. The goal is to see if this approach reduces hospital visits and emergency department stays. About 300 adults with certain cancers (like pancreatic…

This study looks at how exercise might change the body's biology to lower the risk of colorectal cancer returning. Researchers will measure inflammation and other markers in 60 patients who have finished their cancer treatment. The goal is to understand the biological processes b…

This study searches for brand-new gene changes that appear in a person with cancer but not in their parents. By comparing cancer patients, their healthy parents, and other family members, researchers hope to uncover genetic clues that raise cancer risk. The goal is to better iden…

This study looks at how different treatments for recurrent rectal cancer affect patients' well-being and quality of life. About 116 people with rectal cancer that has come back in the pelvis will fill out surveys every 6 months. The goal is to understand the link between treatmen…