New combo shows promise for Hard-to-Treat colorectal cancer
NCT ID NCT04963283
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial is testing a combination of two drugs, cabozantinib and nivolumab, in 48 people with advanced colorectal cancer that has not responded to standard treatments. The goal is to see if the combination can shrink or stabilize tumors. All participants have a type of colorectal cancer called microsatellite stable (MSS), which typically does not respond well to immunotherapy alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- cabozantinib and nivolumab
- What this could lead to
- If successful, this combination could offer a new treatment option to control advanced MSS colorectal cancer when other therapies have failed.
- What could go wrong
- This is a small, early-phase trial with only 48 participants. The combination may not work better than existing options and could cause significant side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for COLON ADENOCARCINOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
UCHealth Family Medicine - Greeley
Greeley, Colorado, 80634, United States
-
UCHealth Harmony Campus
Fort Collins, Colorado, 80528, United States
-
UCHealth Medical Center of the Rockies
Loveland, Colorado, 80538, United States
-
UCHealth Memorial Hospital Central
Colorado Springs, Colorado, 80909, United States
-
University of Colorado Hospital
Aurora, Colorado, 80012, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a plasma beam stop colon polyps from coming back?
- A stitch in time: could a device make abdominal closure safer?
- Can diet and vitamin c supercharge rectal cancer treatment?
- Digital nurse companion: could an app ease the burden of chronic illness?
- Can we predict chemo brain before it happens?
- Your gut bacteria might reveal hidden cancer risk