COLORECTAL ADENOCARCINOMA

This study is testing a new method to personalize a treatment called heated chemotherapy (HIPEC) for people with advanced appendix or colorectal cancer that has spread to the lining of the abdomen. Doctors will test a sample of the patient's tumor in a lab to see which chemothera…

This study is testing a new type of cancer drug that delivers radiation directly to tumors by targeting a protein called Nectin-4. It aims to find a safe and effective dose for patients with advanced solid cancers who have already tried other treatments. The trial will first dete…

This is a first-in-human study testing a new drug called CLSP-1025 for adults with advanced solid tumors that have a specific genetic change called the p53 R175H mutation. The main goals are to find a safe dose and see if the drug can help control the cancer. The drug works by en…

This study is testing the safety and effectiveness of combining two drugs, VS-6766 and cetuximab, for people with advanced colorectal cancer that has a specific genetic change called a KRAS mutation. The study is for people whose cancer has continued to grow despite trying standa…

This study is testing a new first-line treatment for people with advanced, HER2-positive colorectal cancer that cannot be removed by surgery. It combines three drugs—trastuzumab-deruxtecan, capecitabine, and bevacizumab—to see how well they shrink tumors and control the disease. …

This study is testing a new type of cell therapy called A2B395 for adults with advanced solid tumors that have spread or returned. The therapy uses modified immune cells designed to specifically kill cancer cells while protecting the patient's healthy cells. The main goals are to…

This study is comparing two different drug combinations for people newly diagnosed with advanced colorectal cancer that has spread. It will test if a new drug called AK112, when added to standard chemotherapy, works better and is as safe as the current standard treatment of bevac…

This study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have come back or spread. The therapy, called Tmod CAR T, is designed to recognize and kill cancer cells while using a built-in safety switch to protect the patient's healthy …

This study aims to create and validate a new, non-invasive blood test to detect early-onset colorectal cancer in adults under 50. Researchers will analyze tiny genetic signals in the blood using advanced computer models to build a highly accurate test. The goal is to provide a si…

This study is testing a new microwave-based device designed to be used during a standard colonoscopy. The goal is to see if it can safely help doctors find more colorectal polyps, which are growths that can sometimes turn into cancer. The device is being tested in 50 patients who…

This study is testing a new blood test to see if it can better predict which colon cancer patients are at high risk of their cancer returning after surgery. The test looks for tiny pieces of cancer DNA left in the blood. Researchers will enroll 1,600 patients to see if this test …

This study is testing whether a simple blood test can find tiny amounts of leftover cancer cells after treatment. Researchers want to see if this test can predict if colorectal cancer will come back or spread earlier than current scans and check-ups. The study involves collecting…