COLORECTAL ADENOCARCINOMA

This early-stage study tests a new radioactive drug that seeks out a protein called Nectin-4 on cancer cells. It is for people with advanced solid tumors (like bladder, breast, lung, or cervical cancer) that have not responded to prior treatments. The main goals are to find a saf…

This early-phase study tests a new drug, CLSP-1025, in adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have a specific genetic change called p53 R175H and a certain immune type (HLA-A*02:01). The goal is to find a safe dose and see if the drug can …

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors (like colorectal, lung, or pancreatic cancer) that have lost a specific marker on their cells. The treatment uses the patient's own immune cells, modified to target cancer cells while protecti…

This study tests a new lab method to choose the most effective chemotherapy drugs for each person with advanced appendix or colorectal cancer that has spread to the abdomen. About 20 participants will have a sample of their tumor tested to see which drugs work best, then receive …

This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, breast, and kidney cancers) that have not responded to standard therapy. The treatment uses specially engineered immune cells designed to kill cancer cells while protectin…

This phase 3 trial compares a new drug (AK112) plus chemotherapy against the standard treatment (bevacizumab plus chemotherapy) for people with metastatic colorectal cancer that hasn't been treated yet. About 560 adults aged 18-75 with good performance status are being recruited.…

This study is testing a combination of three drugs (trastuzumab-deruxtecan, capecitabine, and bevacizumab) as a first treatment for people with a specific type of advanced colorectal cancer that has spread (HER-2 positive). The goal is to see how well this drug combo shrinks tumo…

This study tests a new microwave-based device that helps doctors find polyps during colonoscopy. About 50 people who already have a polyp in their rectum will take part. The device is used alongside standard colonoscopy to see if it can detect more polyps without causing harm.

This study is testing a new blood test that measures a protein called MMP14 to see if it can better detect colorectal cancer or precancerous growths. Researchers will study 650 adults aged 50 to 74 who already need a colonoscopy after a positive stool test. The goal is to find a …

This study is developing a blood test to detect colorectal cancer in people under 50, a group where cases are rising. The test looks at tiny particles called exosomes and uses machine learning to find cancer signals. Researchers will enroll 400 participants—half with early-onset …

This study looks at whether a simple blood test can find tiny bits of tumor DNA left after treatment, which might help doctors know if colorectal cancer is likely to return. Researchers will collect blood samples from 1,000 adults with colorectal cancer who have completed curativ…

This study aims to confirm that a blood test detecting tumor DNA after colorectal cancer surgery can better predict the risk of cancer returning than current methods. Researchers will follow 1,600 patients who had surgery for stage I-III colorectal cancer to see if the test resul…