Blood test may spare thousands from unneeded colonoscopies

NCT ID NCT06955767

Recruiting now Diagnosis Sponsor: CHU de Reims Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a blood test that measures a protein called MMP14 can help screen for colorectal cancer. Researchers will enroll 650 people aged 50 to 74 who already need a colonoscopy after a positive stool test. By comparing MMP14 levels with colonoscopy results, they hope to find a cutoff that accurately identifies who truly has cancer or precancerous growths, potentially reducing the number of unnecessary colonoscopies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MMP14 blood test
What this could lead to: If successful, this blood test could help avoid unnecessary colonoscopies in people with a positive FIT result, making screening less invasive and more efficient.
What could go wrong: This is an early study to find the best cutoff value, not a treatment trial. The test may not be accurate enough to replace colonoscopy, and results need validation in larger populations.

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Conditions

The condition(s) this trial relates to.

colorectal adenocarcinoma colorectal adenoma colorectal cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL ADENOCARCINOMA

Contacts and locations

Locations

Damien JOLLY
RECRUITING

Reims, France

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