Chu De Reims

This study compares two special dialysis membranes (HYDROLINK and HeprAN) to see if they can safely reduce or eliminate the need for heparin, a blood thinner that raises bleeding risk. About 302 adults on long-term hemodialysis will take part. The goal is to complete dialysis ses…

This study tests whether computer analysis of 3D dental scans can accurately detect gum disease, gingivitis, and cavities, compared to traditional manual exams. About 30 adults with at least one gum recession will participate. If successful, this approach could make dental diagno…

This study is testing whether a blood test that measures a protein called MMP14 can help screen for colorectal cancer. Researchers will enroll 650 people aged 50 to 74 who already need a colonoscopy after a positive stool test. By comparing MMP14 levels with colonoscopy results, …

This study tests whether adding a suprascapular nerve block (a temporary numbing injection) to standard frozen shoulder treatments helps people recover faster. About 62 adults with limited shoulder movement will be randomly assigned to get either the nerve block plus usual care o…

This study tests whether a short, four-session therapy program that helps people rethink their identity and memories related to drinking can reduce alcohol use and cravings. Sixty adults with alcohol use disorder will be randomly assigned to either receive this therapy plus usual…

This study tests a group program called D-MCT that helps women with postpartum depression improve how they think about their own thoughts. About 96 women who have given birth and have depression will either take the program or receive standard care. The goal is to see if the prog…

This study tests whether having specially trained nurses use ultrasound can improve the success rate of placing an IV on the first try in children with difficult veins. About 120 children aged 1 month to 18 years will be randomly assigned to get an IV placed either by the usual m…

This study tests whether adding magnesium sulfate to the standard epidural pain medicine (morphine) can reduce the chance of urinary retention after a C-section. About 1 in 3 women have trouble urinating after surgery, often needing a catheter. The trial will compare magnesium pl…

This observational study looks at how the right side of the heart adapts when critically ill patients receive fluids. Researchers will use ultrasound to measure heart function before and after fluid administration in 100 adults. The goal is to understand why some patients develop…

This study looks at how severe alcohol use disorder changes the brain's ability to understand emotions and social cues. Researchers will use brain scans and tests to compare 60 people with the disorder to healthy volunteers. The goal is to learn how these brain changes affect dai…

This study measures levels of a protein called sCD160 in eye fluid and blood samples from 120 adults with diabetic retinopathy or retinal vein occlusion. Researchers want to see if sCD160 levels are linked to the severity of these eye conditions. Participants provide samples duri…

This study looks at how people with bipolar disorder or major depression process social cues, remember things, and think flexibly. Researchers will test 180 adults using tasks like recognizing emotions in faces. The goal is to better understand these cognitive challenges so that …

This study is gathering detailed information from 470 adults with chronic inflammatory lung diseases like asthma, COPD, and cystic fibrosis, as well as healthy volunteers. Researchers will analyze clinical, biological, and lifestyle factors to identify distinct disease subtypes. …

This study looks at whether a special program of gentle touch and movement (sensory-tonic stimulation) can improve the way very premature babies interact with their parents and develop social thinking. About 120 babies born before 32 weeks will take part. Researchers will film pl…

This study follows 29 children with sickle cell disease who receive MEOPA gas for pain during a crisis. Researchers will check their vitamin B12 levels before and after treatment, and again at 7 days and 1 month. The goal is to see how often MEOPA causes a B12 deficiency and whet…

This study looks at how having a baby early (preterm) affects parents' anxiety and depression, and how that might impact the child's early thinking and social skills. Researchers will compare 60 families of preterm and full-term babies using questionnaires and developmental check…

This study uses brain scans (fMRI) to see if people with severe sleep apnea have unusual brain activity while awake, and whether CPAP treatment changes that. Researchers will compare 70 participants—some with sleep apnea and some without—to understand how the brain compensates fo…

This study looks at how often antiphospholipid syndrome (APS) occurs in people aged 65 and older who have had a stroke or mini-stroke. Researchers will test blood for specific antibodies linked to APS, including some newer ones not yet standard. The goal is to better understand A…

This study looks at how epilepsy affects a child's ability to understand others' thoughts and feelings, known as social cognition. Researchers will compare 96 children aged 6-12 with epilepsy to healthy children of the same age. They will use tests of memory, attention, language,…