Chu De Reims

This study looked at children aged 3 to 15 with overactive bladder caused by nerve problems. It compared two different doses of Botox injections into the bladder muscle to see if a lower dose works just as well as a higher dose. The goal was to improve bladder capacity and reduce…

This study tested whether analyzing urine with a special light technique (spectroscopy) can accurately detect bladder cancer. Researchers collected urine samples from 899 people undergoing cystoscopy. The goal was to see if the light patterns could tell apart those with cancer fr…

This study tested whether changes in pulse pressure during a passive leg raise can predict if a patient needs fluids. Researchers included 39 spontaneously breathing ICU patients with signs of low blood flow. They measured pulse pressure and its variation before and after a leg r…

This study tested whether a special type of MRI (diffusion-weighted MRI) can predict if head and neck cancer will come back after chemoradiotherapy. Fifty-nine patients had two MRIs: one before treatment and one three months after. The goal was to see if changes in water movement…

This study looked at 116 people with small-intestine neuroendocrine tumors to see if a blood test or a shorter urine collection could replace the standard 24-hour urine test for diagnosis. The goal was to find a simpler, equally accurate way to measure a key tumor marker called 5…

This study looked at whether measuring a protein called amyloid beta 1-40 in spinal fluid can help doctors diagnose Alzheimer's disease more accurately. Researchers collected spinal fluid from 204 people with memory problems. They want to see if adding this new measurement to exi…

This study tested whether a single osteopathic session in the emergency department can improve recovery from a mild to moderate ankle sprain. Fifty adults with recent sprains were split into two groups: one got standard medical care, the other got osteopathic treatment. Researche…

This study tested whether wearing a virtual reality headset during an epidural injection for lower back and leg pain can lower pain and anxiety. 116 adults received the injection either with or without the headset. The goal was to see if the immersive experience makes the procedu…

This study compared two ways to manage pain after total hip replacement: a newer ultrasound-guided nerve block (PENG block) versus standard surgical infiltration. The goal was to see which method reduces the need for strong painkillers like morphine, especially in older patients …

This study examined whether a protein called CD160 appears in new blood and lymph vessels that grow in the cornea after a transplant. Researchers analyzed tissue from 43 patients who had corneal transplant surgery. The goal was to see if CD160 is linked to graft rejection, which …

This study tested whether a nurse-driven weaning protocol using capnography (a device that measures carbon dioxide in breath) could help safely remove breathing tubes faster in ICU patients. Fifty adults on ventilators for more than 48 hours were enrolled. Nurses followed a step-…

This study looked at 125 young adults aged 18-25 to understand what makes someone more likely to binge drink. Researchers used brain scans, genetic tests, and thinking skill assessments to find patterns. The goal is to identify risk factors and improve prevention efforts.

This study looked at skin samples from 20 people with hidradenitis suppurativa (HS) who had surgery. Researchers measured different inflammatory proteins in the lab to understand what drives the disease. The goal was to learn more about how inflammation works in HS, not to test a…

This study looked at whether certain blood markers (called PTMDPs) can help identify frailty in people over 65. Researchers collected blood samples from 254 elderly participants and measured these markers. The goal is to find a simple way to detect frailty early so that preventiv…

This study looks at how pregnancy denial—when a woman is unaware she is pregnant for months—affects the bond between mother and child. Researchers will compare 130 mothers, half with pregnancy denial and half without, using interviews and observations over 20 months. The goal is …

This study looked at how the drug methotrexate and its main byproduct leave the body in people with rheumatoid arthritis. Researchers measured levels in urine to create a reference range. This could help doctors identify patients who are not taking their medication as prescribed.

This study examined whether certain genes are linked to a severe form of diabetic eye disease called proliferative diabetic retinopathy (PDR). Researchers analyzed DNA from 302 people with type 2 diabetes, some with PDR and some without. The goal was to find genetic markers that …

This study looked at 100 kidney dialysis patients to understand why their blood vessels get damaged, raising heart risks. Researchers measured harmful substances called AGEs in the blood and skin, and checked for genetic factors. The goal was to learn how these substances interac…

This study looked at whether a simple blood sample can detect genetic mutations in patients with advanced melanoma. Currently, doctors need to take a piece of the tumor (biopsy) to check for key gene changes that guide treatment. The goal was to see if circulating tumor DNA in th…

This study looked at whether a specific antibody, called anti-GBM, could be a useful marker for lupus nephritis—a serious kidney complication of lupus. Researchers tested stored blood samples from 100 people with lupus (some with kidney issues, some without) and compared them to …

This completed study looked at 24 children with acute lymphoblastic leukemia to see if tiny cell fragments called microparticles contribute to dangerous blood clots during treatment. Researchers collected blood samples to measure these particles and a clotting protein on their su…

This study looked at whether measuring elastin fragments in blood or urine can help assess frailty in people aged 65 and older with cancer. Frailty is hard to measure with current methods, which can be slow and subjective. The researchers hope that a biological marker could provi…

This study looked at whether natural aging of proteins in blood vessel walls contributes to the development of aortic aneurysms. Researchers measured skin autofluorescence and collected blood and skin samples from 24 patients undergoing surgery for abdominal aortic aneurysms. The…

This pilot study looked at whether certain natural germ-fighting proteins, called antimicrobial peptides, are linked to chronic gum disease. Researchers collected gum smears from 29 adults with moderate to severe periodontitis and from healthy people to compare gene activity. The…

This study looked at whether the smallest meaningful change in bone density measurements is different for people with obesity compared to those without. Researchers measured bone density twice in 120 adults with a BMI over 30. The goal was to improve accuracy when using bone scan…

This study looked at 150 adults who had severe COVID-19 pneumonia to find out how many develop long-term lung issues. Researchers used CT scans to check for lung scarring and other damage months after infection. The goal is to better understand the lasting effects of severe COVID…

This study looked at whether organochlorine pesticides, which build up in body fat over time, are more common in people with pancreatic cancer. Researchers compared fat and urine samples from 56 patients undergoing surgery—some with pancreatic cancer and some without. The goal wa…

This completed study looked at how thinking skills (like flexibility and self-control) and social understanding (like reading emotions) are connected to alcohol use disorder. Researchers tested 216 people using puzzles, eye-tracking, and brain scans. The goal was to find early wa…

This study used functional MRI to look at brain activity in people with bipolar disorder while they performed tasks involving language and meaning. The goal was to better understand why some patients experience disorganized thinking or speech. 79 participants took part, including…

This study looked at how children born prematurely (before 37 weeks) develop social thinking skills, like understanding others' thoughts and feelings. Researchers tested 56 children aged 7-10 using puzzles and stories, and also surveyed parents about anxiety and stress. The goal …

This study examined 150 adults who had accidentally discovered lumps on both adrenal glands, but no signs of Cushing's syndrome. Researchers checked for mutations in the glucocorticoid receptor gene to see if these genetic changes are more common than previously thought. The goal…

This study looked at how deep brain stimulation (DBS) changes the way people with Parkinson's disease explain positive and negative events, known as attributional style. Researchers measured this in 32 French-speaking adults with Parkinson's who had stable treatment. The goal was…

This study looked at whether a CT scan done 7 days after pancreatic surgery could find complications that doctors hadn't noticed yet. Researchers followed 80 patients who had planned pancreatic surgery. The goal was to see if the scan could detect issues like leaks or infections …

This completed study investigated whether a variation in the CR1 gene makes people more likely to develop Alzheimer's disease. Researchers compared 200 Caucasian participants—some with Alzheimer's and some without—to see if the gene difference is a risk factor. The study did not …

This study looked at how well doctors, residents, and nurses can check a patient's pupils compared to a special device called a pupillometer. Pupil checks are important in the ICU to see how the brain is doing. The study included 30 ICU patients and compared the human assessments…

This study aimed to better understand hearing loss by measuring electrical signals from the hearing nerve during brain surgery. Researchers studied 19 patients with normal hearing or hearing loss to see how nerve fibers respond to sound. The goal was to improve a computer model o…

This completed study in France looked at how common bronchiectasis (permanent lung damage) is in 46 adults with primary humoral immunodeficiency, a condition that weakens the immune system. Participants had a chest CT scan and lung function tests to check for bronchiectasis. The …

This study tested whether a special laser technique called Raman spectroscopy can measure skin fibrosis (hardening) in people with systemic sclerosis, a rare autoimmune disease. Twenty-six adults with the condition had their skin scanned with the laser. The goal was to see if thi…

This completed study followed 183 cancer patients starting checkpoint inhibitor therapy to see how often they develop autoantibodies—proteins that can mistakenly attack the body's own tissues. Researchers collected blood samples to track changes in several types of autoantibodies…

This study looked at driving skills in 60 people over age 70 with early-stage Alzheimer's disease (MMSE score 24 or higher) and compared them to healthy older drivers. The goal was to identify common driving mistakes and suggest adaptive measures or technology to help them drive …