Nurses take the lead: new protocol aims to speed breathing tube removal

NCT ID NCT05000034

Completed Knowledge-focused Sponsor: CHU de Reims Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a nurse-driven weaning protocol using capnography (a device that measures carbon dioxide in breath) could help safely remove breathing tubes faster in ICU patients. Fifty adults on ventilators for more than 48 hours were enrolled. Nurses followed a step-by-step plan to gradually reduce ventilator support, with capnography guiding decisions. The main goal was to see how well nurses could stick to the protocol, not yet to measure patient outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Weaning protocol (nurse-driven, capnography-guided)
What this could lead to: If successful, this could lead to a simpler, nurse-led method to safely remove breathing tubes sooner, reducing infections and hospital stays.
What could go wrong: This is a small, early feasibility study with only 50 patients. It focuses on whether the protocol can be followed, not yet on patient outcomes. Results may not apply to all ICUs.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

WEANING FROM MECHANICAL VENTILATION

Contacts and locations

Locations

Damien JOLLY

Reims, France

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