Why some ICU patients Can't leave the ventilator: diaphragm weakness under the microscope

NCT ID NCT03140267

Terminated Knowledge-focused Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 01, 2026 · Updated 3 times

Summary

This study followed 22 ICU patients who had trouble being taken off a breathing machine (ventilator). Researchers measured two key aspects of the diaphragm—strength and endurance—over 18 hours to see which one is more lacking. The goal was to understand the root cause of weaning failure so that future breathing muscle training can be more effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help design better breathing muscle training programs for ICU patients struggling to come off ventilators.
What could go wrong: This is a very small, observational study (22 people) that only measures muscle function—it does not test any treatment, so it may not lead to direct improvements.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

WEANING FROM MECHANICAL VENTILATION

Contacts and locations

Locations

Hôpital Haut-Lévêque

Bordeaux, 33000, France
Hôpital Pellegrin

Bordeaux, 33000, France

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