University Hospital, Bordeaux

This study compares two blood thinner strategies after left atrial appendage closure (LAAC) in people with atrial fibrillation. Sixty participants will receive either aspirin alone or aspirin plus clopidogrel for three months. The goal is to see which approach better prevents sma…

This study tests whether giving oxybutynin syrup early (starting at 3-6 months old) can improve bladder function in boys born with posterior urethral valves, a condition that blocks urine flow. Fifty boys who had valve surgery will be randomly assigned to receive either oxybutyni…

This trial tests whether a new filtration-based device that recycles a patient's own blood during heart surgery can reduce bleeding better than the standard centrifugation-based device. The study includes adults undergoing high-risk on-pump cardiac surgery. The goal is to see if …

This study looks at two less invasive options—radiofrequency ablation (RFA) and uterine artery embolization (UAE)—for women with heavy bleeding due to adenomyosis who are eligible for hysterectomy. The goal is to see if these treatments can reduce bleeding and pain as well as hys…

This study compares two treatments for men with intermediate-risk prostate cancer: focal HIFU (a targeted ultrasound that destroys only the tumor) and radical prostatectomy (complete removal of the prostate). The goal is to see which approach offers better value for money and qua…

This study tests a combined approach for emergency breathing tube insertion in adults outside the hospital. The strategy includes a muscle relaxant (rocuronium), mask ventilation before intubation, and a special guide (gum elastic bougie). Researchers will compare complication ra…

This study tests whether a new type of PET scan using a tracer called 68Ga-FAPI-46 can more accurately detect the spread of pancreatic and bile duct cancers compared to standard CT and MRI scans. The goal is to see if this scan changes how doctors classify the cancer stage and pl…

This study tests whether special MRI and CT scans can accurately measure the stiffness of kidney tumors. Researchers will compare these scans to standard methods in 50 adults scheduled for kidney tumor surgery. The goal is to improve 3D-printed models that help surgeons plan oper…

This study tests a new, noninvasive method to quickly determine if critically ill children need intravenous fluids. The method uses gentle abdominal pressure and a device that measures blood flow. If accurate, it could help doctors avoid giving unnecessary fluids, which can be ha…

This study looks at whether a simple heart ultrasound test can tell doctors if a child with shock needs more IV fluids. It involves 60 children in intensive care who are on ventilators with low air volumes. The test measures changes in blood flow speed in the aorta during breathi…

This study tests whether a simple, non-invasive nail microscope exam (capillaroscopy) can help doctors find connective tissue disease faster in people newly diagnosed with interstitial lung disease. 48 adults will get the exam alongside standard care. The goal is to see if this e…

This study is testing whether a special PET/CT scan using gallium-68 citrate can more accurately diagnose infections in artificial heart valves. Researchers will compare the scan results with the standard diagnosis after 3 months. The study involves 40 adults with suspected valve…

This study aims to create a new diagnostic score to better identify adrenal adenomas that produce moderate amounts of cortisol, a condition called MACS. Researchers will measure 19 steroid hormones in the blood and combine them with simple clinical factors like BMI, blood sugar, …

This study tests whether measuring a specific receptor (P2X4) on blood cells can help diagnose amyotrophic lateral sclerosis (ALS), a severe nerve disease. Researchers will compare P2X4 levels in 50 people — some with ALS and some healthy volunteers. If the test works, it could l…

This study is testing two new ways to predict gestational diabetes and large babies (macrosomia) in pregnant women. Researchers will measure skin autofluorescence and glycated albumin in 800 pregnant women and compare them to the standard HbA1c test. The goal is to see if these m…

This study aims to see if a protein test on bile fluid can accurately diagnose cholangiocarcinoma (bile duct cancer). Researchers will collect bile samples from 200 adults with bile duct narrowing during a routine scope procedure. They will compare the protein test results with s…

About 13 in 1,000 children are born with heart disease, but current tools struggle to measure how well the heart fills with blood. This study tests a new, ultrafast ultrasound technique that captures images at a very high rate to measure heart stiffness and blood flow. Researcher…

This study tests whether using a computer-aided detection (CADe) system during screening colonoscopy helps find and remove more advanced polyps, potentially lowering the risk of colorectal cancer. About 592 adults at increased risk for colorectal cancer will be randomly assigned …

This study tests whether a shared decision-making tool can help pharmacists and patients better understand when antibiotics are truly needed for uncomplicated cystitis (bladder infection). About 506 women with symptoms will be enrolled. The goal is to reduce unnecessary antibioti…

This study tests a modified surgery that aims to preserve ejaculation in men over 40 with an enlarged prostate, compared to the standard complete removal of prostate tissue. The goal is to see if the new method can relieve urinary symptoms just as well while avoiding the common s…

This study tests whether a hypnosis session before and during a cardiac MRI can reduce anxiety and improve image quality. Researchers will compare anxious patients who receive hypnosis to those who do not, measuring how clear the images are and how many artifacts appear. If succe…

This study looks at whether a simple frailty score can predict how well people aged 75 and older recover one year after emergency heart surgery. Researchers will track quality of life and survival in 265 participants over 12 months. The goal is to see if frailty, measured before …

This study is building a large French registry of up to 30,000 kidney cancer patients. It collects detailed medical information and biological samples over time to support research. The goal is to better understand the disease and improve patient care, not to test a new treatment…

This study tracks 253 cystic fibrosis patients starting a new drug combination (elexacaftor/tezacaftor/ivacaftor). Researchers collect sputum, stool, and blood samples at the start, 6 months, and 1 year to see how the drug changes bacteria and inflammation in the lungs and gut. T…

This study uses PET and MRI brain scans to compare the activity of two key brain chemicals—dopamine and acetylcholine—in 30 people who have had a stroke, half with apathy and half without. The goal is to better understand what causes apathy after a stroke, which could eventually …

This study aims to find unique substances in the blood (biomarkers) that are only present in people with atrial fibrillation, a common heart rhythm problem. Researchers will compare blood samples from 400 patients with AF to those without, and track changes over time. The goal is…

This study follows 250 people who need surgery to repair large bone defects in their lower leg. Researchers will compare two techniques: the Masquelet method and using electromagnetic transport nails. The main goal is to see which approach leads to faster bone healing, as seen on…

This study follows 15,000 people with various spinal conditions (like stenosis, fractures, infections, or cancer spread) to see how their quality of life changes over 5 years. Participants fill out questionnaires about their health and daily activities. The goal is to understand …

This study is testing whether a specialized blood test (MAIPA) can accurately identify autoimmune thrombocytopenia (ITP) in patients with low platelet counts. Currently, ITP is diagnosed by ruling out other causes, which can be slow and uncertain. Researchers will collect blood s…

This study looks at how a type of cell death called ferroptosis, which is driven by iron, might play a role in lupus. Researchers will take blood samples from 120 people with lupus and compare them to people with other autoimmune diseases. The goal is to find new clues for future…

This study looks at whether giving extra nutrition through a feeding tube before surgery can lower the chance of complications in malnourished people with esophageal or stomach cancer. About 670 participants will be followed to compare those who get nutritional support with those…

This study is looking at how cortisol and other steroid hormones are produced over 24 hours in people with adrenal tumors. Researchers will use a special device called U-RHYTHM to take fluid samples every 20 minutes for up to 48 hours. The goal is to compare hormone patterns betw…

This study aims to develop and test a new tool called the Mouth Assessment Tool (MAT) for patients in intensive care who have a breathing tube in their mouth. The tool is designed to help nurses assess the condition of the mouth, which can be affected by the tube. Researchers wil…

This study looks at how reliable the Maintenance of Wakefulness Test (MWT) is for people who feel very sleepy during the day. Researchers will test 100 participants twice to see if the results are consistent. If the test proves reliable, it could help doctors decide who is safe t…

This study is testing new MRI sequences to improve image quality, reduce scan time, and better handle motion from breathing or heartbeat. Two hundred healthy adults will undergo MRI scans without any injections or invasive procedures. The goal is to develop better tools for diagn…

This study tracks 300 adults who developed a surgical site infection after orthopedic surgery on their limbs or spine. Researchers will use questionnaires to measure how often depression and malnutrition occur over one year. The goal is to better understand these complications so…

This study looks at how mitochondrial diseases might weaken the immune system. Researchers will collect blood samples from 60 people with confirmed mitochondrial disorders and compare their immune cells and antibodies to healthy controls. The goal is to better understand these im…

This study looks at people with cerebral small vessel disease, a common condition in older adults that can lead to stroke and dementia. Researchers will measure brain activity using EEG and test whether home-based cognitive training or mild brain stimulation can improve thinking …

This study looks at blood and spinal fluid from 150 people with multiple sclerosis or early symptoms. Researchers want to find which types of B and T cells cause damage in different forms of MS. The goal is to discover new targets for future treatments, especially for progressive…

This study will follow 150 adults with systemic granulomatosis (including sarcoidosis) for up to 10 years. Researchers will track how the disease changes over time and collect blood and urine samples to build a biological database. The goal is to better understand the disease and…

This study follows 1,000 adults with diabetic foot ulcers for up to 5 years to learn why some have worse outcomes, including death. Researchers will track health events and build a risk score to identify those most at risk. The goal is to better understand the disease and improve…

This study looks at 20 adults with severe acute respiratory distress syndrome (ARDS) who are on a ventilator and placed face-down (prone position). Researchers will use electrical impedance tomography (EIT), a non-invasive imaging tool, to measure lung overdistension and collapse…

This study looks at how a special filter (OXIRIS membrane) used for kidney dialysis affects blood clotting and immune cells in intensive care patients with septic shock. Researchers will measure markers of clotting and immune activation before and after using the filter. The goal…

This study is looking for better ways to predict blood clots in people with myeloproliferative neoplasms (MPNs), a group of blood cancers. Researchers will measure specific markers in the blood of 300 participants to see if they can tell who is at higher risk for clots. The goal …

This study examines whether starting kidney dialysis early or later improves outcomes for patients with tumor lysis syndrome, a complication of cancer treatment that can cause acute kidney injury. Researchers will review data from 800 adults treated in ICUs between 2013 and 2023.…

This study aims to translate and validate a French version of the Sleep Regularity Questionnaire (SRQ), a tool that measures how consistent a person's sleep schedule is. Researchers will enroll 50 adults with chronic insomnia or circadian rhythm disorders, who will fill out the q…

This study looks at a blood test that may help doctors decide which children need extra fluids after heart surgery. Giving fluids when not needed can be harmful. The researchers will check if a certain blood marker can predict which children will benefit from fluids. About 110 ch…

This study looks at whether multiple sclerosis (MS) affects a woman's egg supply (ovarian reserve). Researchers will compare blood hormone levels and ultrasound results between 160 women with MS and healthy women aged 25 to 35. The goal is to understand if MS itself impacts ferti…

This study tests whether using a smartphone to answer quick surveys several times a day is a practical way to track restless legs syndrome (RLS) symptoms in real time. Researchers will enroll 62 adults with RLS to use a study phone for 14 days. The goal is to see if patients find…

This study checks if using specially controlled water in reusable bottles during colonoscopy stays free of bacteria from the patient's gut. Researchers will test water samples after each procedure in 40 adults. If the water remains clean, it could lead to a more eco-friendly and …

This study aims to develop a non-invasive blood test that analyzes fetal DNA found in the mother's blood to determine paternity. It is designed for sexual assault victims who become pregnant and need to know the father's identity for legal reasons. The test uses a technique calle…

This study looks at how the brain processes internal body signals in people with Restless Legs Syndrome (RLS). Researchers will use MRI scans and daily smartphone surveys to track brain activity and symptom changes over two weeks. The goal is to understand why the urge to move oc…

This study follows 500 adults with systemic sclerosis (scleroderma) for up to 5 years. Researchers will collect blood samples, and in some volunteers, skin or lung samples, to track how the disease changes over time. The goal is to better understand the natural course of this rar…

This study looks at whether lupus makes the immune system age faster. Researchers will take blood samples from 75 lupus patients to measure changes in immune cells and telomeres (a marker of aging). The goal is to better understand how lupus affects the body over time.