University Hospital, Bordeaux

This phase 3 trial studies whether adding pelvic reirradiation to chemotherapy before surgery can help more patients with locally recurrent rectal cancer achieve complete tumor removal. The study enrolls 58 adults who have had prior pelvic radiation and now face a recurrence. Par…

This Phase III trial tests whether combining baricitinib with an anti-TNF drug (adalimumab or etanercept) works better than baricitinib alone for people with rheumatoid arthritis who haven't responded to prior treatments. The study involves 160 adults aged 18-65 with active disea…

This study tests whether adding metformin, a diabetes drug, to standard methotrexate therapy helps more people with rheumatoid arthritis achieve disease control. About 128 adults with active RA who have not recently taken methotrexate will receive either methotrexate plus metform…

This study tests a combination of two drugs (spartalizumab and low-dose pazopanib) in 80 children and adults whose solid tumors have not responded to standard treatments. The goal is to see if the combo can shrink or stabilize the cancer for at least 6 months. The pediatric part …

This study tests whether virtual reality sessions with a psychologist can improve body image dissatisfaction in people who had bariatric surgery 18 to 30 months ago. Eleven participants will either receive 10 weekly VR sessions or standard follow-up care. The main goal is to see …

This study looks at whether health mediation can help people living in informal housing (like streets, shanties, squats, or caravans) in France use healthcare services more, especially for cancer screening. Over 1,000 participants are involved, along with health mediators and soc…

This study was designed to compare electrical and mechanical activation of the right ventricle in adults who had surgery for Tetralogy of Fallot, a congenital heart condition. Researchers planned to use 3D mapping and imaging to see if electrical signals match the heart's physica…

This study aims to understand inflammation in four chronic skin conditions: vitiligo, psoriasis, eczema (atopic dermatitis), and alopecia areata. Researchers will collect blood and small skin samples from 450 adults to analyze immune cells called T-cells. The goal is to describe …

This study looks at patients with non-small-cell lung cancer that has spread only to the brain (fewer than 5 spots). Researchers will review different treatment strategies used at two hospitals to see which leads to longer survival without the disease getting worse. The goal is t…

This study looks at 500 adults with lupus to see if certain immune markers can better predict who will develop heart disease. Participants give blood samples, have ultrasound scans of their neck arteries, and fill out diet and exercise questionnaires. The goal is to improve how d…

This study follows 66 people with primary progressive multiple sclerosis (PPMS) and healthy volunteers for two years to understand how thinking and memory change over time. Participants take cognitive tests and undergo MRI scans to see how brain tissue damage relates to mental de…

This study is for adults receiving a kidney, lung, liver, or heart transplant. It will collect blood and tissue samples to learn how the body responds to CMV, a common virus that can cause serious problems after transplant. The goal is to better understand the virus and improve f…

This study looks at whether routine screening for heart disease is a good use of healthcare money for people with type 2 diabetes who are at very high risk but have no known heart problems. Researchers will analyze data from 90,000 patients in French health databases to compare c…