Brain scans aim to unlock the mystery of Post-Stroke apathy

NCT ID NCT03998852

Recruiting now Knowledge-focused Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study uses PET and MRI brain scans to compare the activity of two key brain chemicals—dopamine and acetylcholine—in 30 people who have had a stroke, half with apathy and half without. The goal is to better understand what causes apathy after a stroke, which could eventually help doctors choose more effective treatments. Participants will undergo imaging and neuropsychological tests, but no new therapy is being tested.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PET radiotracers ([18F]-FDOPA and [18F]-FEOBV) and MRI
What this could lead to: If successful, this could point toward better, more targeted treatments for apathy after stroke.
What could go wrong: This is a small, early-phase imaging study (30 participants) that does not test any treatment. It may not lead to direct patient benefits.

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Conditions

The condition(s) this trial relates to.

Lethargy stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APATHY

Contacts and locations

Locations

Bordeaux University Hospital
RECRUITING

Bordeaux, 33076, France

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