APATHY

This study is observing how esketamine nasal spray works for people with severe, treatment-resistant depression in real-world clinics. It aims to see who benefits most from the treatment and how it affects their daily life, work, and social functioning. Researchers will also look…

This study is testing whether a daily digital app that helps people reminisce about personal memories can improve symptoms like low mood, lack of motivation, and poor sleep in older adults with mild cognitive impairment or early-stage dementia. Participants will use the app for a…

This study is testing whether a 4-week digital brain training program can help reduce apathy and improve brain function in older adults with depression. Researchers will enroll 84 participants aged 60+ who have both depression and significant apathy. The program aims to strengthe…

This study is testing whether a virtual 'Life Story Club' can help reduce feelings of loneliness and apathy in older adults living independently. Researchers will enroll 50 participants aged 60+ to attend weekly online group sessions for 12 weeks, where they share personal storie…

This study is testing whether a non-invasive brain stimulation technique called rTMS can safely help people who have lost motivation and interest in life after a stroke. Researchers will deliver multiple short stimulation sessions over two weeks to a specific brain area linked to…

This study is testing whether gentle electrical stimulation of the ear (targeting the vagus nerve) can improve apathy—a common loss of motivation—in people with Parkinson's disease. For two weeks, 60 participants will receive either the real stimulation or a sham (fake) treatment…

This study is testing whether a two-part treatment can help reduce apathy, a common loss of motivation, in people with Alzheimer's disease. Researchers are combining a stimulant medication (methylphenidate) with a gentle, non-invasive brain stimulation technique. The goal is to s…

This study aims to find out if a new oral medication called IRL757 is safe and tolerable for people with Parkinson's disease who also experience apathy—a lack of interest or motivation. About 75 participants will take either the study drug or a placebo (inactive pill) daily for 1…

This study aims to understand how listening to personally chosen music might help reduce apathy—a common lack of motivation and emotion—in people with Parkinson's disease. Researchers will enroll 50 participants to use an 8-week music listening program while measuring changes in …