APATHY

This study tests an experimental drug called IRL757 in people with Parkinson's disease who also experience apathy (loss of interest or motivation). The main goal is to see if the drug is safe and tolerable over 12 weeks. About 75 participants will receive either IRL757 or a place…

This study tests whether a virtual group where older adults share their life stories can reduce loneliness and apathy. Researchers will enroll 50 people aged 60 and older who can speak English or Spanish and have internet access. Participants join online reminiscence sessions, an…

This study tests whether a smartphone app that delivers personalized memory sessions can improve symptoms like low mood and lack of motivation in older adults with mild neurocognitive disorders. About 80 participants over age 60 will use the app daily for 25 days. Researchers wil…

This study tests a non-invasive nerve stimulation method (RAVANS) to see if it can improve apathy—a common lack of motivation—in people with Parkinson's disease. Sixty participants will receive either real or sham stimulation for two weeks. Researchers will measure changes in mot…

This study tests whether a 4-week digital cognitive training program can improve apathy and brain function in adults aged 60 and older with major depression. Participants will use a computer program designed to target brain networks linked to motivation and control. The goal is t…

This study explores whether listening to personalized music can help reduce apathy (lack of motivation and emotion) in people with Parkinson's disease. Researchers will use brain scans to see how music affects areas linked to reward and movement. 50 adults with Parkinson's will l…

This study tests whether combining a medication (methylphenidate) with a non-invasive brain stimulation technique (iTBS) can reduce apathy in people with Alzheimer's or mixed dementia. Apathy, or lack of motivation, is common in these conditions. The trial involves 12 participant…

This study tests whether using robots at home can reduce apathy—loss of motivation and interest—in people with mild cognitive impairment or dementia. Participants will be randomly assigned to interact with a telepresence robot, a social robot, or receive standard occupational the…

This study tests whether a fast form of brain stimulation (accelerated rTMS) can safely improve apathy—loss of motivation and withdrawal—in people who had a stroke at least 6 months ago. About 40 adults aged 40+ will receive either real or fake stimulation to a brain area linked …

This study follows 100 adults with treatment-resistant depression who are prescribed esketamine nasal spray as part of their regular care. Researchers will track how well the drug works, who responds best, and how it affects daily life, work, and social functioning. The goal is t…