APATHY

This study tests whether using robots at home can reduce apathy—loss of motivation and interest—in people with mild cognitive impairment or dementia. About 75 adults over 40 with apathy will be randomly assigned to interact with a telepresence robot, a social robot, or receive st…

This study explores whether listening to personally meaningful music can reduce apathy—a lack of motivation and emotion—in people with Parkinson's disease. Fifty participants will listen to their own chosen music or neutral podcasts for 8 weeks. Researchers will use brain scans a…

This study tests an experimental drug called IRL757 in 75 people with Parkinson's disease who also have apathy (loss of interest or motivation). The main goal is to see if the drug is safe and tolerable over 12 weeks. Researchers will also check if it helps improve apathy symptom…

This study tests whether daily 10-15 minute personalized reminiscence sessions delivered by a digital app can improve symptoms like apathy and depression in older adults with mild neurocognitive disorders. Eighty participants over 60 will use the app for 25 days, with a caregiver…

This study tests whether a virtual group reminiscence program called Life Story Club can reduce loneliness and apathy in adults aged 60 and older. Fifty participants will meet weekly over Zoom for 12 weeks to share personal stories. Researchers will measure changes in loneliness,…

This small study tests whether combining methylphenidate (a drug already used for apathy) with a non-invasive brain stimulation technique called iTBS can reduce apathy in people with Alzheimer's or mixed dementia. The trial will include 12 participants who have significant apathy…

This study tests a non-invasive device that stimulates the vagus nerve in the ear, timed with breathing, to see if it can reduce apathy (lack of motivation) in people with Parkinson's disease. 60 participants will receive either the real stimulation or a sham (fake) version for 2…

This study tests whether a fast form of brain stimulation, called accelerated rTMS, can safely improve apathy—loss of motivation and withdrawal—in people who have had a stroke. About 40 adults who had a stroke at least 6 months ago and have significant apathy will receive either …

This study tests whether a 4-week digital brain-training program can reduce apathy (lack of motivation) in older adults with depression. Researchers will measure changes in brain scans and apathy scores. The goal is to see if this non-drug approach can improve brain function and …

This study uses PET and MRI brain scans to compare the activity of two key brain chemicals—dopamine and acetylcholine—in 30 people who have had a stroke, half with apathy and half without. The goal is to better understand what causes apathy after a stroke, which could eventually …

This study follows 100 adults with treatment-resistant depression who are prescribed esketamine nasal spray in real-world clinics. Researchers will track how well the drug works, who responds best, and how it affects daily life and thinking. The goal is to improve personalized ca…