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Can esketamine help when other depression treatments fail? new study aims to find out.

NCT ID NCT07146503

Recruiting now Knowledge-focused Sponsor: Riccardo Guglielmo Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study follows 100 adults with treatment-resistant depression who are prescribed esketamine nasal spray in real-world clinics. Researchers will track how well the drug works, who responds best, and how it affects daily life and thinking. The goal is to improve personalized care for people whose depression hasn't improved with standard treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Esketamine (nasal spray)
What this could lead to
If successful, this study could help doctors predict which patients with hard-to-treat depression will benefit most from esketamine, leading to more personalized treatment.
What could go wrong
This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may not apply to all patients, and esketamine can cause side effects like dizziness, nausea, and dissociation.

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Conditions

The condition(s) this trial relates to.

Anhedonia anxiety anxiety disorder cognitive disorder Depression depressive disorder Depressive Disorder, Treatment-Resistant Lethargy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANHEDONIA ANXIETY APATHY COGNITION DEPRESSION AND QUALITY OF LIFE PSYCHIATRIC COMORBIDITIES TEMPERAMENT TREATMENT RESISTANT DEPRESSION (TRD)

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • ASST Fatebenefratelli Sacco

    RECRUITING

    Milan, 20157, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • ASST Pavia

    RECRUITING

    Pavia, 27100, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Csm Dds 8

    RECRUITING

    Genova, Ge, 16158, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Ospedale Policlinico San Martino

    RECRUITING

    Genova, Ge, 16132, Italy

    Contact Email: •••••@•••••

  • Università di Chieti

    RECRUITING

    Chieti, 66100, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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