ANHEDONIA

This study tests if a smartphone app called Vira, combined with support from a health coach, can help teens aged 12-18 who are struggling with depression and loss of interest in activities. Participants will either use the Vira app with coaching or a different app for comparison.…

This study looks at whether doing a positive mood treatment before exposure therapy can improve outcomes for people with social anxiety and public speaking fears. About 94 adults with social anxiety disorder will be randomly assigned to either a positive mood treatment or a relax…

This study tests whether L-DOPA, a drug used for Parkinson's, can help people with depression who have high inflammation and lose interest in activities. Seventy adults aged 25-55 will receive either L-DOPA or a placebo for 8 weeks. Researchers will track mood, motivation, and br…

This study tests a two-week smartphone program designed to help people who struggle to feel pleasure (anhedonia) and also experience depression, anxiety, or stress. Participants do three short daily exercises like savoring good moments or finding silver linings, delivered via aud…

This study tests whether a gentle electrical current applied to the scalp (tDCS) can activate brain areas linked to pleasure and reward in people with bipolar depression who have lost interest in things they used to enjoy. About 45 adults with bipolar disorder and significant anh…

This study looks at whether the hormone estradiol can help perimenopausal women who started having depression, psychosis, or loss of interest in rewards during this life stage. About 100 women aged 44-55 will receive either estradiol or a placebo, and researchers will use brain s…

This early-stage study explores whether psilocybin, the active ingredient in magic mushrooms, can reduce anhedonia (loss of pleasure) in people with major depression. 85 participants, including healthy volunteers, will receive psilocybin in two sessions—one with a drug that block…

This study tests if a non-invasive brain stimulation technique called tDCS can help young adults (18-35) with mild depression feel better. Participants will receive either real tDCS or a sham (placebo) treatment for 10 sessions over 2 weeks. Researchers will track changes in mood…

This study is testing a digital platform that uses smartphone data (like sleep and activity patterns) to help therapists better support teens at high risk for suicide. About 78 teens aged 13-18 who are already in an intensive therapy program will use the platform alongside their …

This study looks at whether a type of brain stimulation can help people with depression who have trouble feeling pleasure (anhedonia). Researchers will give 72 participants five days of stimulation and measure changes in brain activity and mood. The goal is to understand how brai…

This study follows 415 people with difficult-to-treat depression for 5 years after their original participation. Researchers will review medical records and genetic data to learn how symptoms, suicide risk, and treatment responses change over time. No new treatments are given; th…

This study looks at how a type of talk therapy for PTSD changes brain activity related to feeling pleasure. Researchers will use brain scans to see if therapy helps the brain process rewards better. The goal is to understand why some people feel less joy after trauma and how ther…

This study uses smartphone apps and brain scans to see how your daily emotions, thoughts, and actions are linked. About 100 adults will answer quick surveys and share location data for four months. The goal is to understand patterns in mood and thinking, not to test a treatment.

This study follows 100 adults with treatment-resistant depression who are prescribed esketamine nasal spray as part of their regular care. Researchers will track how well the drug works, who responds best, and how it affects daily life, work, and social functioning. The goal is t…

This study is testing a smartphone app called TrueBlue that helps monitor symptoms of depression and anxiety. It is for adults who are at least 12 weeks pregnant or up to 12 weeks after giving birth. The goal is to see if the app is safe, easy to use, and works well for tracking …