ANHEDONIA

This study is testing a smartphone app called DIGIReward designed to help teenagers aged 13-17 who have recent suicidal thoughts. The app sends daily check-ins and suggests mood-boosting activities. Researchers want to see if teens find the app helpful and easy to use. The study …

This study tests a non-invasive brain stimulation technique called tACS to treat anhedonia (loss of interest or pleasure) in people aged 60 and older with major depression. Eighty participants will receive either real or sham stimulation over two weeks, with follow-up at three mo…

This study is testing a smartphone app called Vira, combined with health coaching, to help teens aged 12-18 who are dealing with depression and loss of interest in activities. The goal is to see if this approach can increase enjoyment and reduce the risk of suicide. Participants …

This study tests whether a non-invasive brain stimulation technique called tDCS can improve mood and motivation in young adults (18-35) with mild depression. Participants will receive either real tDCS or a sham (placebo) treatment for 10 sessions over 2 weeks. Researchers will tr…

This study tests whether estradiol patches can improve anhedonia (loss of pleasure) and psychosis symptoms that start during perimenopause. About 100 women aged 44-55 will receive either estradiol or a placebo patch for three weeks, plus a short course of progesterone. Researcher…

This study looks at whether doing a positive mood treatment before standard exposure therapy can improve outcomes for people with social anxiety and public speaking fears. About 94 adults with social anxiety disorder will first receive either a positive mood treatment or a relaxa…

This study explores whether psilocybin, the active ingredient in magic mushrooms, can help people with depression who have lost the ability to feel pleasure (anhedonia). Researchers will give 85 participants two doses of psilocybin, sometimes blocking its psychedelic effects with…

This study tests a smartphone app called Vira that tracks activity, sleep, and language to help therapists monitor teens at high risk for suicide. 78 teens aged 13-18 receiving intensive outpatient therapy will use the app alongside their treatment. The goal is to see if the app …

This study tests a gentle brain stimulation technique called tDCS to see if it can improve anhedonia—the loss of interest or pleasure—in people with bipolar depression. About 45 adults with bipolar disorder and significant anhedonia will receive tDCS while researchers use brain s…

This study tests whether L-DOPA, a drug used for Parkinson's, can improve anhedonia (loss of interest or pleasure) in people with depression who also have high inflammation. Seventy adults aged 25-55 will receive either L-DOPA or a placebo for 8 weeks. Researchers will measure ch…

This study tests a two-week smartphone program designed to help people who struggle to feel pleasure (anhedonia) and also have high depression, anxiety, or stress. Participants do three short audio-guided exercises each day, focusing on gratitude, savoring positive moments, and f…

This study looks at whether inflammation in the brain causes symptoms like loss of interest and slow movement in depressed people with HIV. Sixty participants will receive either the anti-inflammatory drug baricitinib or a placebo for 10 weeks. Researchers will use brain scans an…

This study uses smartphone tracking and brain scans to see how your daily emotions, thoughts, and actions are linked. About 100 adults will answer quick surveys and share location data for four months. The goal is to better understand patterns in mood and thinking, not to test a …

This study looks at how a type of talk therapy called Cognitive Processing Therapy (CPT) changes brain circuits related to reward and pleasure in people with PTSD. Researchers will use brain scans to track these changes in 120 participants. The goal is to understand why some peop…

This study follows 415 people with difficult-to-treat depression for 5 years after they joined an earlier genetics study. Researchers will review medical records and registry data to see how patients' depression changes over time, including suicide attempts and treatment response…

This study follows 100 adults with treatment-resistant depression who are prescribed esketamine nasal spray in real-world clinics. Researchers will track how well the drug works, who responds best, and how it affects daily life and thinking. The goal is to improve personalized ca…

This study tests whether a non-invasive brain stimulation technique called tACS can improve goal-directed behavior in people with depression who have lost interest in activities (anhedonia). 72 participants will receive five daily sessions of stimulation. The goal is to see if th…

This study is testing a mobile app called TrueBlue that automatically measures mood in pregnant women and new mothers. Researchers want to see if the app is safe, easy to use, and agrees with standard depression questionnaires. About 125 participants in Nottinghamshire, UK, will …