ANHEDONIA

This study tested whether adding a new daily pill called aticaprant to a person's current antidepressant could better treat major depression, specifically for people who experience a severe lack of pleasure (anhedonia). Over 500 adults who weren't getting enough benefit from thei…

This study tested whether customizing a magnetic brain stimulation treatment could help people with hard-to-treat depression who struggle to feel pleasure. 60 participants received either personalized stimulation, standard stimulation, or a sham (placebo) treatment over one week.…

This study tested a personalized brain-training therapy for people with major depression who struggle to feel pleasure. 19 participants were randomly assigned to receive either the real therapy or a sham version to compare safety and effectiveness. The goal was to see if this the…

This study tested whether adding a new drug called aticaprant to a person's current antidepressant could help improve symptoms in adults with major depression who also experience a severe loss of pleasure (anhedonia) and haven't gotten enough relief from their current medication.…

This study tested a family-focused program designed to prevent depression in children whose mothers have a history of depression. It involved 73 children aged 8-12 and their mothers, who participated in 8 online sessions. The main goal was to see if the program could improve how …

This small, early-stage study tested whether adding the drug pramipexole could help people with depression who specifically struggle with anhedonia—the inability to feel pleasure or motivation. The drug, typically used for Parkinson's disease, was given alongside participants' ex…

This study tested a new drug called ALTO-203 for people with major depression, especially those who struggle with a lack of pleasure (anhedonia). It involved 69 participants who received either the drug or a placebo to see how it affected their mood and alertness, and to check it…

This study aimed to understand how inflammation might affect feelings of pleasure and motivation in older adults, particularly those with anxiety. Researchers gave 40 participants aged 60-80 either a substance that causes temporary inflammation or a placebo, then measured their m…

This study aimed to understand how temporary inflammation might affect the brain's reward system—how we anticipate and enjoy things—in women. Researchers gave 40 healthy, premenopausal women either a low-dose substance to trigger a brief inflammatory response or a placebo, then m…