Brain-training device shows promise for depression with anhedonia
NCT ID NCT05869708
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This small study tested a device called Prism that uses neurofeedback to train the brain to regulate its own activity. Nineteen adults with major depressive disorder and anhedonia (loss of pleasure) were randomly assigned to real or sham training sessions over several weeks. The goal was to see if the device is safe and can reduce depression symptoms and improve the ability to feel pleasure.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Prism neurofeedback device (brain-training using real-time feedback)
What this could lead to
If it works, this could offer a non-drug option to help people with depression who also struggle with anhedonia (loss of pleasure).
What could go wrong
This was a very small, early study (19 people) comparing active to sham training. Results may not apply to everyone, and the device is not yet proven effective.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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McLean Hospital
Belmont, Massachusetts, 02478, United States