Tailored magnetic pulses aim to restore pleasure in depressed patients
NCT ID NCT05537285
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested a personalized form of brain stimulation for people with depression who no longer feel pleasure (anhedonia). Sixty adults received either individualized, standard, or fake magnetic pulses to the brain over one week. The goal was to see if tailoring the stimulation to each person's brain activity could better improve mood and restore enjoyment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Accelerated Intermittent Theta Burst Stimulation (aiTBS) using a magnetic coil device
What this could lead to
If successful, this could lead to a more effective, personalized brain stimulation treatment for people with depression who have lost interest or pleasure in activities.
What could go wrong
This is a small, early-stage study (60 people) comparing different types of stimulation. The results may not apply to everyone with depression, and the benefits might be modest or temporary.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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UCSD Interventional Psychiatry
San Diego, California, 92127, United States