MDD

This pilot study tests whether a portable, at-home brain stimulation device (tDCS) can help people with depression maintain the improvements they achieved during hospital treatment with esketamine, rTMS, or ECT. Thirty adults will use the device for 30 minutes a day, five days a …

This study tests whether wearing a headset that delivers a flickering 60Hz white light for 30 minutes a day can help ease depression symptoms. Adults with major depressive disorder will use the device at home for three weeks. Researchers will measure how well people stick with th…

This study tests whether inhaling DMT, a psychedelic drug, can quickly reduce symptoms of major depression and suicidal thoughts. 140 adults with moderate-to-severe depression will receive either a high or low dose of DMT in two puffs. Those not improved after a week can get an e…

This Phase 2 trial tests LV232, a new capsule for major depressive disorder, in 400 adults aged 18-65. Participants are randomly assigned to receive one of two doses of LV232, the active comparator escitalopram, or a placebo for 8 weeks. The main goal is to find the best dose and…

This study tests whether a single 25 mg dose of psilocybin can relieve major depression in 100 adults with cancer, compared to a very low 1 mg dose. Participants must be 20–80 years old, have had depression for at least a month after their cancer diagnosis, and stop other antidep…

This study tests whether taking omega-3 (EPA) supplements for 12 weeks can reduce depressive symptoms in overweight or obese adults who have depression and low omega-3 levels. Half of the 50 participants will receive EPA, and half will receive a placebo. Researchers will also loo…

This study is for adults aged 22-65 with major depression that hasn't improved with other treatments. Researchers want to see if giving psilocybin (the active ingredient in magic mushrooms) followed by a quick, focused brain stimulation technique is safe and can help reduce depre…

This study tests whether a gentle brain stimulation technique called tDCS, done at home, can improve sleep quality in adults with moderate depression. Researchers will track sleep changes and see if better sleep leads to better mood. The study involves 35 participants and aims to…

This study compares women with PMDD, major depressive disorder (MDD), and healthy controls to see how their brains, stress responses, and inflammation differ. Researchers will use brain scans, stress tasks, and blood/saliva tests in 75 naturally cycling women aged 18-40. The goal…

This study observes 100 people with depression who are already receiving transcranial magnetic stimulation (TMS) therapy. Researchers use brain scans and symptom questionnaires to see how brain networks change during treatment and whether these changes can predict who gets better…