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Could a blood test spot teen suicide risk?

NCT ID NCT05437588

Recruiting now Knowledge-focused Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study investigates whether tiny particles called exosomes, released by brain cells and found in the blood, can serve as biomarkers for depression and suicide risk in adolescents. Researchers will analyze genetic material from these exosomes in 240 teenagers, including those with depression, suicidal thoughts, or a recent suicide attempt, as well as healthy volunteers. The goal is to better understand the biological links between depression and suicide, which could eventually lead to better screening and treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple blood test that helps doctors identify teenagers at risk for suicide, enabling earlier intervention.
What could go wrong
This is an observational study, not a treatment trial. The biomarkers may not prove reliable enough for clinical use, and results may take years to translate into practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder endogenous depression major depressive disorder Suicide Suicide, Attempted

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION DEPRESSION AND SUICIDE DEPRESSION IN ADOLESCENCE DEPRESSION, TEEN MAJOR DEPRESSIVE DISORDER MDD SUICIDAL IDEAS SUICIDE SUICIDE, ATTEMPTED

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • UAB Huntsville Regional Medical Campus

    RECRUITING

    Huntsville, Alabama, 35294, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact

  • University of Alabama at Birmingham

    RECRUITING

    Birmingham, Alabama, 35233, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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