SUICIDE

This study tests a 6-month remote case management program called Pathfinding for active-duty Army soldiers recently discharged from inpatient psychiatric care. Participants receive guidance via video or phone to set goals and connect with resources. The goal is to see if this ext…

This study tests a program called Friendship Bench + Safety Planning for teens aged 13-19 living with HIV who have had suicidal thoughts. The goal is to see if the program is practical, acceptable, and helps reduce suicidal thoughts and improve engagement in HIV care. Sixty parti…

This study tests whether text messages can help parents lock up guns and medications after their teen's suicide-related emergency room visit. About 129 teens aged 12-17 and their parents will be followed for 12 weeks. The goal is to see if simple reminders can reduce access to da…

This study tests a gamified mobile health app designed to reduce suicide risk in adults with mental disorders after they leave the hospital. Researchers will enroll 640 participants in Shenzhen, China, and use game-like features to encourage treatment adherence and follow-up visi…

This study tests a 90-day program called Caring Connections for youth aged 13-19 who are at high risk for suicide. The program helps them stay engaged with mental health services, create safety plans, and build a support network. Researchers will compare 40 youth who receive the …

This study looks at 136 Veterans recently hospitalized for suicide risk. Half will get a longer psychotherapy, half a shorter one, to see which works better at reducing suicidal thoughts and actions. Researchers will also use MRI brain scans to track changes over a year and see i…

This study is testing whether combining internet-based cognitive behavioural therapy (i-CBT) with intravenous ketamine can quickly reduce suicidal thoughts and behaviors in people with treatment-resistant depression. All 110 participants will receive weekly i-CBT for 13 weeks, an…

This study tests a brief problem-solving therapy to prevent suicide in adults aged 50 and older who have suicidal thoughts. The therapy is delivered in three formats: face-to-face, by phone, or via a smartphone app. 212 participants will be randomly assigned to one of these forma…

This study tests a brief therapy program (ASSIP-OA) designed to prevent suicide in adults aged 65 and older who have recently attempted suicide or had serious suicidal thoughts. About 132 participants will receive either the program plus usual care, or usual care alone. Researche…

This study is testing a 90-day support program called 'Caring Connections' designed to prevent suicide in high-risk teenagers. The program connects teens with mental health services, helps create safety plans, and builds a network of community support, often through faith-based o…

This study tests whether a new drug called HNK can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with their depression …

This study tests a smartphone app that shares stories from teens who have overcome suicidal thoughts. The goal is to see if these stories help other at-risk teens feel less suicidal and more connected. The study involves 46 adolescents in The Bronx who have had recent suicidal th…

This study tests a sleep-focused program (TranS-C) plus bright light therapy in 90 teens aged 12-18 with moderate to severe depression and sleep problems. Half get the full program with a sleep therapist and light glasses; the other half just track their sleep. The goal is to see…

This study tests whether inhaling DMT, a psychedelic drug, can quickly reduce symptoms of major depression and suicidal thoughts. 140 adults with moderate-to-severe depression will receive either a high or low dose of DMT in two puffs. Those not improved after a week can get an e…

This study tests a mobile app designed to reduce stigma and increase knowledge about suicide, making it easier for people to seek help. About 214 Spanish-speaking adults will use the app, with some starting right away and others after a delay. The goal is to see if the app improv…

This study aims to find the best way to prevent suicide in young people ages 12-24 who are at high risk. Researchers will compare two short, proven crisis interventions given in emergency rooms: one focuses on creating a safety plan and follow-up calls, while the other teaches sk…

This early-stage trial tests whether a single low-dose injection of ketamine is safe and practical for adults who come to the emergency department with severe suicidal thoughts. Researchers will monitor side effects and ask staff about their experience. If successful, it could of…

This study tests a new talk therapy called Continuous Identity Cognitive Therapy (CI-CT) for veterans who have recently had a suicidal episode. The goal is to help them feel more hopeful, build a positive sense of self, and improve their quality of life. About 57 veterans will ta…

This study tests a smartphone app called Vira that tracks activity, sleep, and language to help therapists monitor teens at high risk for suicide. 78 teens aged 13-18 receiving intensive outpatient therapy will use the app alongside their treatment. The goal is to see if the app …

This study is testing a type of talk therapy, called Brief Cognitive Behavioral Therapy for Suicide Prevention, delivered via video call. The goal is to see if it can reduce suicidal thoughts and attempts in adults with physical disabilities affecting vision, hearing, or mobility…

This study is testing two online cognitive behavioral therapy (CBT) courses for veterans who are at risk for suicide or have depression. One course focuses on depression symptoms, and the other on suicidal thoughts and behaviors. The goal is to see if veterans find these self-gui…

This study tests a single 90-minute therapy session called Brief Skills for Safer Living (Brief-SfSL) to see if it can reduce suicidal thoughts in adults. Researchers will enroll 150 participants across Canada, with half receiving the therapy immediately and the other half after …

This pilot study tests a 12-week therapy called Integrated Suicide and Trauma Therapy (ISTT) in 20 adults with a history of childhood trauma and current suicidal thoughts. The therapy combines coping skills training with trauma-focused treatment to address both suicide risk and t…

This study compares two types of counseling for young people aged 13-24 who come to the emergency room with suicidal thoughts or actions. One approach is a single session called SAFETY-A that involves the youth and their family, and the other adds extra follow-up support. Researc…

This study tests a new short-term treatment called Suicidal Crisis Intervention (SCI) for adults who have attempted suicide or are in a suicidal crisis. The goal is to reduce suicidal thoughts and related feelings like hopelessness. About 390 participants will be randomly assigne…

This study compares two brief suicide prevention interventions adapted for sexual and gender diverse young adults aged 18-24. Participants are recruited from primary care clinics and receive the intervention via telehealth. The goal is to reduce suicidal thoughts and improve acce…

This pilot study tests a mobile app called MIST designed to reduce suicidal thoughts in veterans. The app uses techniques to change unhelpful beliefs linked to suicide. Fifty veterans with recent suicidal thoughts will try the app alongside their usual care, and researchers will …

This study tests a digital system called e-Connect that helps probation staff identify suicide risk in youth involved with the justice system and quickly connect them to mental health services. The trial involves probation and treatment staff across 9 Indiana counties. Researcher…

This study follows 500 adults already receiving care for depression, bipolar disorder, or suicide risk at the NIH. Researchers will conduct weekly interviews and optional tests like blood draws and brain scans to track symptoms and treatment responses. The goal is to better under…

This study tests whether giving emergency room doctors a computer-generated risk score for suicide can help prevent suicide attempts. About 4,000 adults coming to the ER for psychiatric issues will be randomly assigned so that their doctor either sees or does not see their risk s…

This study is testing whether a Peer Support Specialist program can help LGBTQ+ youth (ages 12-17) who are involved in the juvenile justice, child welfare, or mental health systems and have thoughts of suicide or self-harm. The program pairs youth with trained peers to improve re…

This study adapts a suicide risk screening program called the NIMH Clinical Pathway for use in two school-based health centers in rural West Virginia. Researchers will work with 30 participants—students, parents, and providers—to see if the program is practical and effective at i…

This study looks at why people with mood disorders may be at risk for suicide. Researchers will collect blood, urine, and survey answers from 300 participants to find patterns and build a model that predicts suicide risk. The goal is to better understand the factors involved so d…

This study is testing whether a combination of therapy (CBT) and a team of caring adults chosen by the teen can help Black adolescents who are thinking about suicide or have hurt themselves. The study will enroll 15 Black teens aged 12-17 and their chosen support people. Research…

This study tests whether calling people back after they contact a suicide helpline helps them feel supported and connected to care. Researchers will interview callers and helpline staff to see if the callback system works well and is helpful. The goal is to improve how the helpli…

This study enrolls 200 teens with a history of self-inflicted injury, including at least one suicide attempt. Researchers will teach two skills from Dialectical Behavior Therapy (Opposite to Emotion Action and GIVE) and track how often teens use them in daily life via phone surve…

This study tests a suicide prevention package (PSuPP) in rural Nepal's primary care clinics. Researchers will train healthcare workers to better identify and support people at risk of suicide. The pilot involves 147 participants and focuses on whether the program is practical and…

This study tests whether sending daily text messages to parents of teens who visited the ER for suicide risk can help prevent future suicide attempts and reduce parental stress. About 420 parent-teen pairs will take part, with parents receiving either supportive texts or standard…

People in detention are at much higher risk of suicide than the general population. This study works with 40 participants—20 prison staff and 20 detained individuals—to adapt three suicide prevention tools for use in prisons. Through interviews, researchers will gather feedback t…

This study looks at how the 24-hour patterns of sleep and social activity relate to mood and suicidal thoughts in older adults who recently lost a spouse or life partner. Researchers will track 169 participants for 12 months using surveys and activity monitors. The goal is to und…

This study tests whether brief phone calls or text messages from a trained clinician can help people hospitalized for suicidal thoughts use their safety plan. Participants answer questions on their smartphone up to 4 times a day and may receive a just-in-time intervention based o…

This study looks at how to help Suicide Intervention Officers (SIOs) in the Connecticut Army National Guard do their job. SIOs are trained to spot soldiers in crisis and connect them with help, but they often lack support. The study will test a package of support options and see …