Can a psychedelic inhaler lift depression fast?

NCT ID NCT07562191

Recruiting now Symptom relief Sponsor: Universidade Federal do Rio Grande do Norte Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 14, 2026 · Updated 3 times

Summary

This study tests whether inhaling DMT, a psychedelic drug, can quickly reduce symptoms of major depression and suicidal thoughts. 140 adults with moderate-to-severe depression will receive either a high or low dose of DMT in two puffs. Those not improved after a week can get an extra high-dose session. Researchers will track mood and safety for up to a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: N,N-Dimethyltryptamine (DMT) inhaled via vaporizer
What this could lead to: If it works, this could point toward a fast-acting treatment for major depression and suicidal thoughts.
What could go wrong: This is a mid-stage trial with only 140 people. The high dose may cause intense psychedelic effects, and it's unclear if benefits last or beat existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endogenous depression major depressive disorder Suicidal Ideation Suicide

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSION MAJOR DEPRESSIVE DISORDER (MDD) MDD SUICIDAL IDEATION SUICIDE

Contacts and locations

Locations

Complexo Hospitalar Universitário Professor Edgard Santos, Federal University of Bahia (HUPES-UFBA)
NOT_YET_RECRUITING

Salvador, Estado de Bahia, Brazil
Hospital Universitário Onofre Lopes - HUOL - UFRN
RECRUITING

Natal, Rio Grande do Norte, Brazil
Hospital de Saúde Mental Professor Frota Pinto
NOT_YET_RECRUITING

Fortaleza, Ceará, Brazil
Instituto de Psiquiatria - Hospital das Clínicas - IPq - HC - USP
NOT_YET_RECRUITING

São Paulo, São Paulo, Brazil
Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro (IPUB-UFRJ)
NOT_YET_RECRUITING

Rio de Janeiro, Rio de Janeiro, Brazil

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