Can a psychedelic inhaler lift depression fast?
NCT ID NCT07562191
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether inhaling DMT, a psychedelic drug, can quickly reduce symptoms of major depression and suicidal thoughts. 140 adults with moderate-to-severe depression will receive either a high or low dose of DMT in two puffs. Those not improved after a week can get an extra high-dose session. Researchers will track mood and safety for up to a year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
N,N-Dimethyltryptamine (DMT) inhaled via vaporizer
What this could lead to
If it works, this could point toward a fast-acting treatment for major depression and suicidal thoughts.
What could go wrong
This is a mid-stage trial with only 140 people. The high dose may cause intense psychedelic effects, and it's unclear if benefits last or beat existing treatments.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Complexo Hospitalar Universitário Professor Edgard Santos, Federal University of Bahia (HUPES-UFBA)
NOT_YET_RECRUITINGSalvador, Estado de Bahia, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Hospital Universitário Onofre Lopes - HUOL - UFRN
RECRUITINGNatal, Rio Grande do Norte, Brazil
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Hospital de Saúde Mental Professor Frota Pinto
NOT_YET_RECRUITINGFortaleza, Ceará, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Instituto de Psiquiatria - Hospital das Clínicas - IPq - HC - USP
NOT_YET_RECRUITINGSão Paulo, São Paulo, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
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Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro (IPUB-UFRJ)
NOT_YET_RECRUITINGRio de Janeiro, Rio de Janeiro, Brazil
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••