SUICIDAL IDEATION

This study compares a new, lower-energy seizure therapy (LAP-ST) to standard electroconvulsive therapy (ECT) for quickly reducing suicidal thoughts in people with depression, bipolar disorder, or schizoaffective disorder. The goal is to see if the gentler approach works just as w…

This study tests an online training program for school counselors to help them prevent suicide among teenagers. The program aims to improve counselors' knowledge, confidence, and attitudes about suicide prevention. About 60 counselors from secondary schools in Turkey will take pa…

This study tests a brief therapy program (ASSIP-OA) designed to prevent suicide in adults aged 65 and older who have recently attempted suicide or had serious suicidal thoughts. About 132 participants will receive either the program plus usual care, or usual care alone. Researche…

This study tests whether adding a crisis response plan (CRP) to prolonged exposure (PE) therapy helps reduce suicidal thoughts and behaviors in people with PTSD. Researchers will compare PE plus CRP to PE with standard care in 100 adults. The goal is to find a better way to suppo…

This pilot study tests whether a peer support program can help young adults (ages 18-27) recently discharged from a psychiatric hospital. Participants get one-on-one and group meetings with trained Peer Support Specialists and recovery organizations, while a comparison group rece…

This study is testing a smartphone app called DIGIReward designed to help teenagers aged 13-17 who have recent suicidal thoughts. The app sends daily check-ins and suggests mood-boosting activities. Researchers want to see if teens find the app helpful and easy to use. The study …

This study tests a new type of transcranial magnetic stimulation called theta burst stimulation (TBS) to see if it can reduce suicidal thoughts in adolescents aged 12-18 with major depressive disorder. Participants receive TBS over 10 days and are followed for one year. The goal …

This study tests whether inhaling DMT, a psychedelic drug, can quickly reduce symptoms of major depression and suicidal thoughts. 140 adults with moderate-to-severe depression will receive either a high or low dose of DMT in two puffs. Those not improved after a week can get an e…

This study tests whether four intravenous ketamine infusions over two weeks can reduce suicidal thoughts in 36 adults with major depression. Participants will also have two MRI brain scans to see if changes in brain structure relate to symptom improvement. The goal is to both tre…

This study tests whether a digital avatar (virtual coach) program can help young adults aged 18-29 who come to the emergency department with alcohol misuse and suicidal thoughts. About 60 participants will either use the avatar program with supportive texts or a free suicide safe…

This study is testing an app called Jaspr that helps teens and young adults with suicidal thoughts create a safety plan and learn coping skills. The app includes videos and tools for teens, parents, and healthcare providers. Researchers want to see if using the app improves how w…

This study is testing a structured program called SHIELD to help young people aged 15-30 who have suicidal thoughts or self-harm. The program includes 8 weekly sessions tailored by age, focusing on stabilizing daily routines and emotions. Researchers will compare it to usual care…

This study tests if a 6-month therapy called Dynamic Deconstructive Psychotherapy (DDP) works better than standard care plus Brief Intervention and Contact (BIC) for reducing suicidal thoughts in teens and young adults aged 14-40. About 106 participants will be randomly assigned …

This early-stage trial tests whether a single low-dose injection of ketamine is safe and practical for adults who come to the emergency department with severe suicidal thoughts. Researchers will monitor side effects and ask staff about their experience. If successful, it could of…

This study tests a magnetic brain stimulation technique called iTBS in 55 veterans aged 22-65 who have had a mild traumatic brain injury and struggle with impulsivity or suicidal thoughts. The treatment involves applying magnetic pulses to the front of the head over several sessi…

This study tests a program called SUPERCEDE, which provides intensive case management to veterans who are at risk for suicide and receive care both from the VA and outside community providers. The goal is to improve care coordination, reduce suicidal thoughts, and improve daily f…

This study tests whether a 9-week therapy called Engage & Connect can improve brain function related to social reward and reduce suicidal thoughts in older adults with depression. Researchers will use brain scans to measure changes in key brain networks. The study involves 128 pe…

This study tests a non-invasive brain stimulation treatment called TMS for teens and young adults (ages 15-25) with depression and suicidal thoughts. Over 5 days, participants receive 10 sessions of magnetic pulses per day, guided by MRI scans. Researchers want to see if this fas…

This study tests whether adding a brief crisis coping strategy (Crisis Response Planning) to a standard talk therapy (Cognitive Processing Therapy) can lower suicidal thoughts and behaviors in veterans with PTSD. About 190 active-duty service members and veterans with PTSD and re…

This study is testing a digital platform called Jaspr Health that provides suicide risk assessment and coping skills to people in the emergency department who are having suicidal thoughts. About 670 participants will use the app with help from a research coordinator and continue …

This study is testing a type of talk therapy, called Brief Cognitive Behavioral Therapy for Suicide Prevention, delivered via video call. The goal is to see if it can reduce suicidal thoughts and attempts in adults with physical disabilities affecting vision, hearing, or mobility…

This study tests whether deep transcranial magnetic stimulation (dTMS) is safe and helpful for teens aged 14-18 who are hospitalized with major depression and suicidal thoughts. About 60 participants will receive either real or sham dTMS alongside their usual care. The goal is to…

This study tests a program called TAILOR, which uses sleep-focused therapy to help teens with insomnia who are also having suicidal thoughts. The goal is to see if improving sleep can lower their risk of suicidal behavior. The study will enroll 235 teens aged 11-18 and track chan…

This study tests an online recovery program for teens aged 15-18 who have been discharged from a psychiatric hospital after suicidal thoughts, attempts, depression, or anxiety. The program pairs them with trained peer support specialists and teen peers for one-on-one and group me…

This study looks at how well a 20-week therapy called Dialectical Behavior Therapy for Adolescents (DBT-A) works for teens aged 13-18 who self-harm or have suicidal behavior. Researchers will track self-harm episodes, suicide attempts, depression, and quality of life right after …

This study tests whether a smartphone app called Sleepio, which teaches better sleep habits, can help teens ages 14-18 who were recently hospitalized for suicide risk and also have insomnia. Half the teens will use the app plus get their usual care, while the other half gets usua…

This study tests a 40-minute web-based program designed to teach veterans coping skills for suicidal thoughts. Researchers will compare veterans who use the program to those receiving standard care, measuring changes in suicidal thoughts and behaviors over one month. The goal is …

This pilot study tests a new type of talk therapy called Shame-Focused Cognitive Behavioral Therapy (SF-CBT) for teens hospitalized after a suicide attempt or with severe suicidal thoughts. The therapy aims to reduce feelings of shame, which are linked to suicide risk. About 42 t…

This study tests a new short-term treatment called Suicidal Crisis Intervention (SCI) for adults who have attempted suicide or are in a suicidal crisis. The goal is to reduce suicidal thoughts and related feelings like hopelessness. About 390 participants will be randomly assigne…

This study tests a non-invasive brain stimulation technique called accelerated theta burst stimulation to reduce suicidal thoughts in people with treatment-resistant depression. About 76 adults will receive either bilateral or unilateral stimulation to see which works better. The…

This study compares two brief suicide prevention interventions adapted for sexual and gender diverse young adults aged 18-24. Participants are recruited from primary care clinics and receive the intervention via telehealth. The goal is to reduce suicidal thoughts and improve acce…

This study tests whether wearing special glasses that emit blue light each morning for two weeks can improve mood, sleep, and reduce suicidal thoughts in military members with mild depression. Researchers will compare the active blue light to a placebo light to see if the timing …

This study tests a digital program called I-CARE for teens aged 12-17 who are stuck in the emergency room waiting for a psychiatric hospital bed. The program uses tablet-based videos and workbook exercises to teach coping skills. Researchers want to see if it reduces suicidal tho…

This study tests a mobile app called WellPATH-PREVENT for adults aged 50-90 who were recently hospitalized for suicidal thoughts or a suicide attempt. The app teaches emotion regulation skills to help reduce suicide risk. Researchers will measure changes in brain activity, self-r…

This study tests a program called Project RISE for college students who have had suicidal thoughts or eating issues. The program teaches skills like body awareness, emotional understanding, and healthy self-care through four modules. Researchers will compare it to a general healt…

This study investigates why some adolescents act impulsively when experiencing negative emotions, a trait called negative urgency. Researchers will measure brain cell communication using transcranial magnetic stimulation and EEG in teens aged 13-21 with depression and suicidal th…

This research study examines how brain activity changes during emotional and thinking tasks in people with depression and healthy volunteers. Using brain scans (EEG, fMRI) and mild brain stimulation (TMS), researchers aim to understand the brain circuits involved in mood and suic…

This study tests a program called WeCare for Black youth aged 12-19 who come to emergency departments with suicide risk. The program includes a quick screening, a brief safety planning session, and supportive text messages for six weeks. Researchers will see if this approach help…

This study investigates the psychological processes—such as feelings of being a burden, impulsivity, and suicidal thoughts—that may lead to risk-taking and suicidal behavior. Researchers will follow 1,400 vulnerable adolescents and adults aged 12 to 65, including those already re…

This study is developing and testing a program called THRiVE for veterans who recently left the military. The program consists of six weekly virtual group sessions led by a peer (another veteran). The goal is to see if the program is practical, well-liked, and may help improve me…

This study examines whether climate anxiety is linked to suicidal thoughts and behaviors in young people aged 16 to 24 who are receiving psychiatric care. Researchers will use questionnaires to measure climate anxiety, general anxiety, and suicide risk in 108 participants. The go…

This study looks at whether being awake during the late-night hours (2:00-4:00 AM) can worsen mood, increase hopelessness, and impair decision-making in people who have had suicidal thoughts in the past six months. Researchers will monitor 90 adults in a lab and at home under dif…

This study at Yale University is testing whether blocking a specific brain receptor (AMPA) stops ketamine from reducing suicidal thoughts. Thirty adults with depression, bipolar disorder, or PTSD who have current suicidal thoughts will receive either perampanel (an AMPA blocker) …

This study is testing a short educational program for teens aged 12-17 who have had recent suicidal thoughts. The program teaches them how to use social media in active and helpful ways, rather than passively scrolling. Researchers want to see if this approach can reduce feelings…

This study tests a digital program called Flourish (formerly imHere4U) designed to help teens aged 12-17 who have been cyberbullied and are at risk for suicide. About 80 teens will be randomly assigned to either use Flourish plus fill out questionnaires or just fill out questionn…

This study looks at how childhood trauma and stress affect tiny genetic molecules called microRNAs in the blood. Researchers will compare people with major depression and healthy volunteers to see if these molecules can help explain the link between early life stress and suicidal…

This study tests a digital program called Flourish that aims to prevent suicide in teens who are bullied online. About 20 middle and high school students will use the program for 12 weeks. Researchers will see if it reduces distress and suicidal thoughts, and if schools can easil…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve the accuracy of mental health surveys. Researchers in Hong Kong will ask 2,500 adults about their mental health using either a standard interview or one…

This study follows 200 teens aged 12-18 who use cannabis daily or near-daily and have some depression symptoms. Using smartphone surveys several times a day, researchers track cannabis use, mood, and suicidal thoughts to see how they change over time. The goal is to learn when an…

This study aims to create a treatment prognosis calculator for military personnel with suicidal thoughts. Researchers will test whether a specialized therapy called Brief Cognitive Behavioral Therapy (BCBT) works better than standard care for those predicted not to respond to usu…

This study aims to understand which emotion regulation strategies work best for military personnel experiencing suicidal thoughts. Researchers will track 334 service members in real time using smartphone surveys to see how strategies like distraction, social support, or thinking …

This study looks at how the brain works in people who have attempted suicide compared to those who have only thought about it. Researchers will use simple computer tasks to measure things like impulse control and attention. The goal is to find patterns that might help predict who…

This study follows up to 10,000 medical students in Orléans, France, for up to 22 years to understand what puts them at risk for depression and other mental health issues. Participants fill out an annual online questionnaire. The goal is to identify early warning signs so that fu…

People in detention are at much higher risk of suicide than the general population. This study works with 40 participants—20 prison staff and 20 detained individuals—to adapt three suicide prevention tools for use in prisons. Through interviews, researchers will gather feedback t…

This study is testing a smartphone app designed to help young adults aged 16 to 30 who are having suicidal thoughts. The app asks users to answer quick questions about their feelings and risks throughout the day. The goal is to see if the app is easy to use and helpful for both p…

This study looks at which treatments work best to prevent suicide in teens aged 11 to 17 who have been hospitalized for suicidal thoughts or actions. Researchers will compare different intervention strategies to see which ones reduce suicide attempts and related crises. The goal …