SUICIDAL IDEATION

This trial tests whether a safety planning intervention plus follow-up phone calls, delivered either by emergency department staff or via a telehealth referral center, can reduce suicide attempts and deaths in adults who come to the ER with suicidal thoughts or behaviors. Over 2,…

This study looks at whether a combination of ibogaine-magnesium, 5-MeO-DMT, magnetic e-Resonance therapy (MeRT), and physiological supplements can help special operations veterans with PTSD, depression, suicidal thoughts, and cognitive problems from traumatic brain injury. Partic…

This study tests whether a short counseling session called Crisis Response Planning (CRP) helps reduce suicidal thoughts and attempts in active-duty military members who come to the emergency department with suicide risk. Participants are randomly assigned to receive CRP or stand…

This study tests a revised version of motivational interviewing, a type of counseling, to see if it can lower suicide attempts and suicidal thoughts in high-risk veterans. About 470 veterans will be randomly assigned to receive this therapy or high-quality usual care. The goal is…

This study tests a short, home-based therapy called ASSIP Flex for adults who have attempted suicide. The therapy involves 3-4 sessions delivered in the patient's own environment. Researchers will track suicidal thoughts and behaviors over 12 months to see if the therapy is feasi…

This study tests a tablet-based app called Jaspr that helps adults with suicidal thoughts while they wait in the emergency department. The app guides users through suicide risk assessment and safety planning based on proven therapies. Researchers will track whether it reduces sui…

This study tests whether a mobile app called Jaspr, which teaches skills to manage suicidal thoughts, works better with or without extra human support. About 50 college students who have had recent suicidal thoughts or behaviors will use the app and report their progress. The goa…

This study tests if a 6-month therapy called Dynamic Deconstructive Psychotherapy (DDP) works better than standard care plus Brief Intervention and Contact (BIC) for reducing suicidal thoughts in teens and young adults aged 14-40. About 106 participants will be randomly assigned …

This study tests a program called I-CARE for teens aged 12-17 who are in a medical hospital waiting for mental health treatment after a suicide-related emergency. The program uses 7 short videos and workbook activities to help lower emotional distress and suicidal thoughts. Resea…

This pilot study tests a chatbot named SMILEY that teaches coping skills and safe social media practices to marginalized youth (ages 12-18) who experience depression and online victimization. Over 4 weeks, participants interact with the chatbot at their own pace to learn how to m…

This study tests whether a single injection of ketamine can quickly reduce suicidal thoughts in people with depression who come to the emergency room. About 90 participants will receive either ketamine or a sedative (midazolam) and be monitored for 24 hours. The trial is currentl…

This study tests a 12-session group therapy program (G-BCBT) for active duty military personnel who have recent suicidal thoughts or a recent suicide attempt. The therapy teaches emotion regulation, cognitive flexibility, and relapse prevention skills. Researchers will measure ch…

This study tests two new ways to help teens aged 13-17 who have suicidal thoughts or self-harm. One uses a small device that gently stimulates a nerve in the ear to help control emotions. The other is a smartphone app that connects teens with a supportive peer. The goal is to see…

This study aimed to see if a single 45-minute dose of inhaled nitrous oxide (laughing gas) could quickly reduce suicidal thoughts and depression in people visiting the emergency department. It was designed for adults aged 18-65 with major depressive disorder who were actively sui…

This study compares two suicide prevention programs designed specifically for autistic youth aged 12-24. One program is a safety planning intervention (SPI-A), and the other adds follow-up contacts (SPI-A+). Researchers will track changes in suicidal thoughts and behaviors over a…

This study looks at whether adding a brief therapy to esketamine nasal spray works better than the spray alone for reducing suicidal thoughts in people with hard-to-treat depression. About 56 adults aged 18 to 70 with ongoing suicidal thoughts will take part. The goal is to see i…

This study tests whether inhaling nitrous oxide (laughing gas) can quickly reduce suicidal thoughts in people hospitalized for depression. Fifty adults with major depression and active suicidal ideas will receive either nitrous oxide or a placebo gas, plus their usual treatment. …

This study tests a program called Nae Disha for Life to see if it can reduce suicide thoughts in young people aged 12-17 in rural India. About 272 students from 4 schools will take part. The program teaches resilience and coping skills to help ease suicidal thoughts and anxiety.

This pilot study tests a mobile app designed to reduce suicidal thoughts in teenagers. It will enroll 228 teens aged 13-17 who were recently hospitalized for a suicide attempt or have a history of attempts. Participants will use either the experimental app or a standard informati…

This study tests a teaching method called Cooperative Learning, where teens work in small groups with the help of technology. The goal is to see if this approach can reduce anxiety, depression, and suicidal thoughts in 1,200 students. The method is designed to be easy for schools…

This trial tests a 6-week therapy program for youth (ages 12-17) who come to the emergency department with suicidal thoughts or behaviors. The program involves weekly sessions with a therapist for the teen and their family. Researchers want to see if this focused approach reduces…

This study is testing a safety planning intervention designed for children ages 6-12 who have had suicidal thoughts or behaviors in the past month. Researchers want to see if the plan is clear and helpful to children and their caregivers, and whether it can reduce suicidal behavi…

This study follows 100 teens aged 13-18 who are already enrolled in a depression registry. For 30 days, they report their feelings and social media use twice daily via a phone app, then complete monthly surveys for 6 months. The goal is to understand how social media relates to d…

This study is creating a large registry of 5,000 young people aged 8 to 20 who have depression or suicidal thoughts. Researchers will collect data from clinics across Texas to better understand these conditions and develop models to predict outcomes. The goal is to improve popula…

This study aimed to enroll 150 people at different risk levels for self-harm to understand how brain activity and blood markers relate to suicide risk. Participants would have received brain scans, blood tests, and three different treatments (neurofeedback, transcranial magnetic …

This study aims to understand how the brain's pain-processing systems relate to a person's ability to attempt suicide. Researchers will use fMRI scans to measure brain activity in 90 adults with depression while they experience pressure pain. The goal is to identify neural patter…