Could laughing gas stop suicidal urges in minutes?

NCT ID NCT05710887

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aimed to see if a single 45-minute dose of inhaled nitrous oxide (laughing gas) could quickly reduce suicidal thoughts and depression in people visiting the emergency department. It was designed for adults aged 18-65 with major depressive disorder who were actively suicidal. The study was withdrawn before enrolling any participants, so no results are available.

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Conditions

The condition(s) this trial relates to.

Depression Depressive Disorder, Treatment-Resistant major depressive disorder Suicidal Ideation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Chicago Medicine

    Chicago, Illinois, 60637, United States

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