University Of Chicago

This study tests two programs for people recently in jail or under supervision. One offers health navigation; the other adds employment help and small financial incentives. The goal is to see which better helps participants access HIV care, prevention, and jobs. About 350 Black m…

This study tests whether transplanting insulin-producing cells from deceased donors can help people with brittle type 1 diabetes control blood sugar without insulin shots. Up to 20 adults aged 18-70 will receive the cells through a vein. The main goal is to see if this approach i…

This study tests whether empagliflozin, a medicine used for diabetes and heart conditions, can change urine chemistry to reduce the risk of forming calcium kidney stones. Researchers will give 32 adults with a history of calcium stones the drug daily for 4 weeks and measure key f…

This study tests a new drug called Tegoprubart in people with type 1 diabetes who have dangerous low blood sugar and are getting islet cell transplants. The drug aims to prevent the immune system from attacking the new cells without using standard anti-rejection medicines that ca…

This study tests whether support from a friend or family member can help people with HIV keep their medical appointments and lower the amount of virus in their body. About 900 people aged 18-49 in Chicago and Alabama who have missed visits or have uncontrolled HIV will take part.…

This study tests whether taking aspirin after delivery can prevent heart damage in women who had preeclampsia, a serious pregnancy condition. Researchers will measure heart function and blood markers in 180 women over 6 months. If successful, aspirin could offer a simple, low-cos…

This study is testing a specific chemotherapy combination (epirubicin + cyclophosphamide followed by docetaxel + carboplatin) in Nigerian women with triple-negative breast cancer. The main goal is to see how many women have no cancer cells left in their breast or lymph nodes afte…

This study is for people with multiple myeloma that has returned or is no longer responding to standard treatments, including CAR T-cell therapy. Researchers are testing a combination of four drugs (belantamab mafodotin, carfilzomib, pomalidomide, and dexamethasone) to see if it …

This study tests whether surgically closing a small hiatal defect (where the stomach bulges into the chest) can control acid reflux in people with early GERD. Researchers will enroll 40 adults aged 18-50 who have a small defect and proven acid reflux. The goal is to see if this p…

This study tests adding a new drug called capivasertib to a standard treatment for adults with certain types of leukemia or lymphoma that have come back or not responded to treatment. The standard treatment includes venetoclax and low-intensity chemotherapy. The study has three p…

This early-phase trial is testing whether adding the targeted drug ruxolitinib to standard chemotherapy is safe for adolescents and young adults (ages 12-39) with a specific, high-risk form of acute lymphoblastic leukemia called Ph-like ALL. The study aims to find the best dose a…

This study tests two different combinations of drugs used to treat shock in intensive care patients. The goal is to see which combination causes fewer dangerous heart rhythm problems and helps more patients survive. About 836 adults in the ICU who need these drugs will take part.

This study is testing a shorter course of pelvic radiation for women with endometrial or cervical cancer. The goal is to see if giving slightly higher daily doses over fewer days is safe and tolerable. About 100 women who have already had surgery will participate. The study will …

This study tests whether adding a drug called relacorilant to standard hormone therapy and enzalutamide can better shrink high-risk prostate cancer before surgery. About 90 men with advanced, localized prostate cancer that hasn't spread will take the combination for 24 weeks, the…

This study tests a new surgical method called PoRSHA for repairing large or recurrent paraesophageal hernias. Instead of using synthetic mesh, the surgeon uses a flap of the patient's own abdominal lining to reinforce the diaphragm. The goal is to see if this approach reduces her…

This early-phase study tests a combination of two drugs, selumetinib and azacitidine, in about 18 adults with higher-risk blood cancers like MDS, MDS/MPN, and myelofibrosis. The main goal is to find the safest dose of selumetinib when given with standard azacitidine. Treatment co…

This study tests whether semaglutide, a medication used for weight loss, can help control atrial fibrillation (AF) in overweight or obese adults. About 200 people aged 18-75 with AF and a BMI of 30 or higher will receive semaglutide alongside standard AF care. The goal is to see …

This study tests whether giving the immunotherapy drug toripalimab with chemotherapy before standard treatment can shrink HPV-related throat cancer tumors by at least half. About 30 people with advanced HPV16-positive oropharyngeal cancer will receive the drug combo, then either …

This early-phase study tests a new three-drug combination (zanzalintinib, pembrolizumab, and cetuximab) in adults with recurrent or metastatic head and neck cancer that cannot be cured by local treatments. The main goal is to find the safest dose and check for early signs of tumo…

This early-phase study tests whether adding fulvestrant to standard radiation therapy (Lu-DOTATATE) can safely shrink tumors in people with advanced pancreatic neuroendocrine tumors that cannot be surgically removed. About 25 adults with low- or intermediate-grade tumors will rec…

This study tests a combination of two drugs, lenvatinib and pembrolizumab, in people with advanced anal or rectal cancer that has spread and no longer responds to standard chemotherapy. The goal is to see if this treatment can shrink tumors or slow the disease. About 35 participa…

This early-stage trial tests a combination of two drugs, ivosidenib and ruxolitinib, in people with advanced blood cancers (MPNs) that have a specific IDH1 mutation. The study aims to find the safest dose and see how well the combination works. About 18 participants will be enrol…

This study tests whether adding focused radiation to a standard drug combination (durvalumab plus chemotherapy) can help people with extensive-stage small cell lung cancer live longer without the cancer getting worse. About 49 adults who have not yet been treated for this advance…

This study looks at whether regularly screening for diabetes-related emotional distress can help adults with type 2 diabetes improve their blood sugar levels. About 1,250 adults with high blood sugar (A1C over 8%) will take part. Researchers will track changes in A1C and choleste…

This study is testing whether using MRI scans to guide radiation therapy can lower the dose to healthy parts of the prostate while giving a higher dose to cancer spots. The goal is to reduce bowel-related side effects and preserve quality of life. About 60 men with intermediate- …

This study tests a new experimental drug, LP-118, combined with three other medicines (ponatinib, vincristine, and dexamethasone) in adults with T-cell acute lymphoblastic leukemia or lymphoma that has come back or not responded to treatment. The main goals are to find a safe dos…

This study tests a combination of three drugs (volrustomig, paclitaxel, and carboplatin) in people with untreated HPV-negative head and neck cancer that has spread locally but not to other parts of the body. The goal is to see how many patients experience significant tumor shrink…

This early-stage trial tests whether giving a mix of healthy gut bacteria (from donors) to people hospitalized with liver disease is safe and tolerable. The study involves 24 adults with liver failure or cirrhosis who have low levels of certain gut chemicals. Researchers will mon…

This study tests whether a low dose of tocilizumab, a drug used for arthritis and COVID-19, can help people with sickle cell disease who develop acute chest syndrome—a serious lung complication. Researchers will measure how the drug affects oxygen levels and other outcomes in 200…

This early-phase study tests a new combination of five chemotherapy drugs for people with advanced cancers of the upper digestive system, including pancreatic and stomach cancers. The goal is to find the safest dose based on a person's genetic makeup, which affects how the body p…

This study is for Nigerian women with a specific type of breast cancer called HER2-positive. Doctors want to see if giving a combination of targeted drugs before and after surgery can destroy the cancer completely. About 74 women will receive the treatment, and researchers will c…

This study looks at whether two common immunotherapy drugs, nivolumab and pembrolizumab, can be given less frequently than the current standard schedule. Researchers will measure drug levels in the blood of 264 adults with advanced or metastatic cancer to see if extended interval…

This study tests whether a spinal cord stimulator can reduce pain and improve blood flow in the legs of people with type 2 diabetes who have nerve pain. About 25 adults will receive the device and be monitored for changes in pain, circulation, and vessel stiffness. The goal is to…

This study tests whether transplanting insulin-producing islet cells from deceased donors can help people with type 1 diabetes who have already had a kidney transplant. The goal is to achieve better blood sugar control without needing insulin shots. Ten participants aged 18 to 68…

This study is for people whose head and neck cancer has come back after previous treatment. It tests a new combination of drugs (tislelizumab and pamiparib) given together with chemotherapy and a second round of radiation. The main goal is to find the safest dose and see if this …

This study is testing whether regular MRI scans can find aggressive prostate cancers earlier in men who are at high risk. Researchers will follow 250 men for up to 15 years, giving them an MRI every 3 years. The goal is to see if MRI can detect high-grade cancers sooner than stan…

This study is testing whether a simple, non-invasive stool test called FIT can accurately detect colorectal cancer in people with Lynch Syndrome, a genetic condition that raises cancer risk. Researchers will compare FIT results to standard colonoscopy findings in 400 participants…

This study aims to see if a quick, painless measurement of muscle activity can help doctors diagnose ALS earlier and more accurately. Researchers will test this new method on 650 people, including those with ALS symptoms, healthy volunteers, and ALS patients followed over time. T…

This study is checking if a simple finger prick test can accurately detect current or past Toxoplasma infection, compared to standard lab blood tests. About 210 adults, including pregnant women, will take part. The goal is to see if the finger prick test is reliable enough for wi…

This study tests a computer program developed at the University of Chicago that creates risk maps from MRI scans of the prostate. The goal is to see if this tool helps doctors decide where to biopsy more accurately than current methods. About 180 adults with known or suspected pr…

This study looks at whether a surgery called immediate lymphatic reconstruction (ILR) can prevent lymphedema—painful arm swelling—in people having lymph nodes removed during breast cancer treatment. Researchers will measure arm size and fluid levels in about 90 participants to se…

This study aims to increase use of PrEP (a daily pill that prevents HIV) among Black women in community health clinics in the Midwest and South. Researchers will test four strategies: training clinic staff, educating patients, improving electronic health records, and providing pa…

This study tests a new surgical technique called immediate lymphatic reconstruction (ILR) done at the same time as lymph node removal for breast cancer. The goal is to prevent lymphedema, a painful arm swelling that can happen after surgery. Researchers will follow 100 women to s…

This study tests whether placing the heart medication amiodarone directly into the sac around the heart during bypass or valve surgery can prevent a common complication called atrial fibrillation (irregular heartbeat) after the operation. About 63 adults aged 20-85 having open-ch…

This study is testing whether eating a high-fiber, low-fat diet for three weeks before colorectal cancer surgery can change gut bacteria to help prevent the cancer from returning or spreading. About 80 adults with colorectal cancer who are scheduled for surgery will take part. Re…

This study tests whether watching educational videos can help people aged 65 and older who are having bladder cancer surgery (cystectomy) avoid problems like trouble moving, medication issues, and lower quality of life. Participants watch videos with tips and fill out questionnai…

This study tests a new weight loss program for young adults ages 18 to 40 who are overweight or obese. It combines a smartphone app with behavioral coaching to help participants lose weight over 6 months. The goal is to find better ways to help young people manage their weight an…

This study looks at how long people need to wear a cast after thumb arthritis surgery. Some patients will wear a cast for 2 weeks, others for 6 weeks. The goal is to see if a shorter cast time leads to less stiffness and faster return to daily activities. About 90 adults aged 40 …

This study tests a web-based program called OMGYES.com to see if it helps young adult female cancer survivors with sexual health problems. About 30 people will take part, using online modules at home and visiting the clinic every 5 weeks. The goal is to see if the program is prac…

This study tests a pre-surgery exercise program for frail adults who need chest surgery. The goal is to see if getting stronger before surgery helps people recover faster and have fewer problems after the operation. About 100 adults will take part.

This study is testing a mobile health app designed to help young adults (ages 18-26) quit using e-cigarettes and other vaping products. The app translates proven smoking-cessation methods into a smartphone format. Researchers will enroll 46 participants who vape regularly and wan…

This study is for people with multiple myeloma whose doctors recommend radiation. Normally, radiation takes 2-3 weeks, but this trial tests a shorter course (hypofractionation) with slightly higher daily doses to see if it is safe. About 30 participants will receive pelvic radiat…

This study tests an 8-week home program for minority women with urinary incontinence or related symptoms. The program combines cognitive behavioral therapy, behavior changes, and physical therapy exercises, with support from research staff and a custom AI chatbot. The goal is to …

This study looks at whether adding guided spiritual care sessions to standard hospital care is possible and helpful for adults with acute leukemia. About 70 participants will be randomly assigned to either receive these sessions or usual care. The goal is to see if patients accep…

This early study tests whether a neuroprosthesis can restore touch sensation to the breast and reduce chronic pain in 8 women who have had both breasts removed and are undergoing reconstruction. Researchers will use tiny electrical pulses to stimulate nerves and measure what part…

This study tests whether Astepro nasal spray, already used for allergies, can help manage COVID-19 symptoms and lower the amount of virus in the body. About 280 adults with early COVID-19 will use the spray or a placebo for 10 days. Researchers will track symptoms, viral load, an…

This study tests whether numbing a specific nerve in the knee (a nerve block) provides better pain relief after surgery for a broken knee bone than the usual approach of numbing just the incision area. The trial will enroll 38 adults undergoing this surgery. Researchers will meas…

This study tests whether the anti-inflammatory drug ibuprofen can lower high PSA levels in men. High PSA often leads to prostate biopsies, but inflammation can also raise PSA. The trial will enroll 200 men with elevated PSA but no known prostate cancer, giving them ibuprofen to s…

This study tests whether auricular acupressure (pressing small seeds on the ear) can help people aged 50 and older prepare for major lung surgery. The goal is to see if this simple technique improves appetite, energy, sleep, and reduces anxiety before the operation. Forty partici…

This study tests if placing a numbing medicine (bupivacaine) into the bladder after kidney stone surgery can lower pain and improve recovery. About 116 adults having ureteroscopy with stenting will receive either the medicine or a saltwater placebo. The goal is to see if this sim…

This study looks at women with urgent bladder control problems who choose a nerve stimulation device. It compares a 3-day test period to the usual 7-day test to see if the shorter time works just as well. The goal is to make the process faster and more convenient without reducing…

This study tests whether using a freeze spray (ethyl chloride) before a corticosteroid injection can reduce pain and anxiety. About 300 adults receiving their first joint or soft-tissue injection for conditions like arthritis or carpal tunnel will be asked to rate their pain and …

This study compares a continuous cooling therapy device to traditional ice packs for managing pain after open carpal tunnel release surgery. About 128 adults having the surgery will be randomly assigned to one of the two cooling methods. The main goal is to see if the cooling dev…

This study looks at whether a surgery to remove part of the lung lining (partial pleurectomy) can help reduce symptoms and improve quality of life in people with advanced pleural mesothelioma that cannot be fully removed. About 30 participants will have the surgery and fill out s…

This study looks at whether giving caffeine can help children wake up more quickly after being sedated for an MRI scan. The sedative used, dexmedetomidine, is safe but can make kids sleepy for a long time. The trial will involve 100 children aged 3 to 12 and measure how fast they…

This study looks at whether a simple blood test can find HPV DNA in people with HPV-related anal or cervical cancer who are getting radiation therapy. Researchers will take blood samples before, during, and after treatment to see if the virus's genetic material shows up and if it…

This study looks at whether a treatment called hypoglossal nerve stimulation (HGNS) for obstructive sleep apnea can improve how the body processes sugar and lower heart risks. About 30 overweight or obese adults who cannot use a CPAP machine will take part. Researchers will measu…

This study looks at whether measuring how older adults walk at home can help doctors understand their recovery after major abdominal surgery. Researchers will ask 100 participants aged 60 and older to do short walking tests using their mobile devices before and after surgery. The…

This study looks at how kidney stones, insulin resistance, and inflammation are related. Researchers will compare 20 people who have had calcium kidney stones (but not diabetes) with 20 healthy people. They will measure belly fat, blood markers, and urine to understand these conn…

This study aims to create and test a personalized program for women going through menopause who have a higher risk of dementia. The program will help them manage their fears and learn healthy coping strategies. Researchers will first talk to small groups of women to understand th…

This study collects DNA samples from 1200 adults receiving routine care at the University of Chicago. Researchers test for genetic differences that could affect how patients respond to certain medications, including risk of side effects. The results are shared with their doctors,…

This study looks at whether a two-day employment program can help young Black men who have sex with men stay engaged in HIV care. About 132 participants will attend the program and complete surveys over 13 months. The main goal is to see if the program is acceptable and feasible,…

This study collects blood and tissue samples from 500 people having heart surgery at the University of Chicago Medical Center. Researchers will study these samples to learn more about heart disease and how to improve treatments. Participants must be English-speaking and are not g…

This study looks at how obstructive sleep apnea (pauses in breathing during sleep) affects blood sugar levels in adults with type 1 diabetes. Researchers will monitor 40 participants' glucose patterns using continuous glucose monitors. The goal is to understand if sleep apnea mak…

This study compares two types of metal rods used to fix broken shinbones: a standard rod and a special rod that allows tiny movements (micromotion). The goal is to see which rod helps the bone heal faster and with fewer problems. About 372 adults with unstable shin fractures will…

This study looks at how the heart works in people with severe traumatic brain injury or bleeding in the brain. Researchers will collect heart and brain monitoring data that is already part of routine care. They will follow up with participants 6 months after leaving the hospital …

This study aims to see if adding blood and urine tests to an AI-based risk score can better predict which hospitalized patients will develop severe acute kidney injury (AKI). Researchers will enroll 800 adults at high risk and collect samples over three days. The goal is to impro…

This study compares two radiation techniques for people with 1 to 5 brain tumors that have spread from other cancers. Half the participants will receive standard radiation with a 2 mm safety margin, while the other half will get radiation with no extra margin. The goal is to see …

This study looks at whether giving doctors and pharmacists genetic information about their African American patients can help them prescribe medications more safely, especially the blood thinner warfarin. About 1,000 African American adults will take part. The goal is to see if t…

This study aims to better understand how well fat transfer works for breast or chest wall reconstruction. Researchers will use 3D photographs, MRI, and ultrasound to measure changes in breast shape and volume over time. Fifteen adults planning this surgery will also fill out a qu…

This study looks at how two natural compounds in food—oxalate and citrate—interact in the body and affect kidney stone risk. Researchers will give potassium citrate to 24 adults (some with a history of kidney stones, some without) and measure changes in their urine over six hours…

This study compares two common methods for removing IVC filters—small devices placed in a vein to catch blood clots. Researchers want to see if using rigid forceps or an endovascular snare works better and faster. About 100 adults who need their filter removed will take part.

This study looks at how changes in gut bacteria (dysbiosis) may contribute to Long COVID symptoms like fatigue, brain fog, and stomach issues. Researchers will collect stool and blood samples from 400 people—half with Long COVID and half without—to compare gut health and immune f…

This study aims to create a registry of 400 women at high risk for breast cancer to test whether a shorter, abbreviated MRI scan works as well as a full-length MRI for early detection. Participants will be scanned every 6 months. The goal is to develop faster, personalized screen…

This study looks at whether community health workers sharing personal stories on social media can encourage people to get recommended vaccines for flu, COVID-19, and other respiratory viruses. About 1,400 health workers and their followers will take part. Researchers will measure…

This study tests whether a special clinic that checks your genes and all your medications can lower the risk of harmful drug interactions. About 1,300 adults with cancer or mental health conditions who take multiple drugs will get a consultation. The goal is to help doctors presc…

This study collects lung tissue from patients undergoing lung transplant to investigate what causes pulmonary fibrosis at the cellular level. Researchers will examine cells and proteins from the donated lungs. The goal is to better understand the disease, not to test a new treatm…

This study looks at how celiac disease damages the gut and how it heals. Researchers will study 220 adults, including those on a gluten-free diet, those with active symptoms, and healthy controls. The goal is to better understand the disease and improve care for patients.

This study looks at how two natural compounds in food—oxalate and citrate—affect the chance of forming kidney stones. Researchers will measure changes in urine after giving oxalate to 50 adults, some with a history of stones and some without. The goal is to better understand why …

This study creates a large database of men with prostate cancer who choose prostate ablation (a minimally invasive treatment) instead of active surveillance or more aggressive therapies. Researchers will collect medical records from up to 3,000 participants to see how well ablati…

This study aims to find the genes and mutations that cause inherited heart conditions like cardiomyopathy and arrhythmia, as well as muscular dystrophy. Researchers will collect DNA samples from patients and their families, focusing on those with multiple affected relatives. The …

This study works with community leaders and adults who smoke to find out what makes quitting harder and to design a better support program. Researchers will test a new smoking cessation treatment in a small group of 24 people to see if it is practical and well-liked. The goal is …

This study looks at whether elderly men (70+) with prostate cancer who have been on hormone therapy for over 3 years can stop taking it. The idea is that their bodies may already be permanently unable to produce testosterone, so the shots may no longer be needed. Researchers will…

This study looks at how diet and sex influence the chance of developing kidney stones after gastric bypass surgery. About 28 people who are approved for surgery will eat a special diet for six days and visit the clinic three times. Researchers will measure urine changes to unders…

This study looks at adults with liver cirrhosis who do not have diabetes and are waiting for a liver transplant. Researchers want to find out if simple tests like blood work, activity monitors, and glucose sensors can predict who will develop diabetes after the transplant. Partic…

This study looks at whether giving sleep tips to expecting parents can help their babies sleep longer and have fewer sleep problems. About 391 families will take part. Some parents will get regular sleep advice by email and fill out surveys, while others will not. Researchers wil…

This study tests a faster way to find and treat PTSD in primary care clinics on Chicago's South Side, where trauma is common. Researchers will track how many people get screened, diagnosed, and start treatment, and whether their symptoms improve. About 17,000 adults who have had …

This study tests a 12-week education and support program for African American adults with advanced chronic kidney disease. Participants will either receive the program or standard care. The goal is to see if the program helps patients learn more about their condition, manage it b…

This study looks at whether people with ulcerative colitis (UC) who have no signs of inflammation can safely lower or stop their medication. About 200 adults with UC in deep remission will either continue their current therapy or reduce/stop it, based on random assignment or pers…

This study looks at whether giving doctors a patient's genetic information before surgery can help them choose safer medicines. About 1900 adults having planned surgery at the University of Chicago will give a blood sample to test for genes that affect how they respond to common …

This study looks at how working a 24-hour shift affects the immune system of surgery residents. Researchers will measure changes in immune cells and inflammation before and after the shift. The goal is to understand the health impact of sleep deprivation on doctors in training.

This study looks at how a very low dose of LSD (13 micrograms) affects mood and behavior, and whether knowing you took the drug changes those effects. 48 healthy adults will be split into groups: some are told exactly what they receive (LSD or placebo), others are not. Researcher…

This study looks at whether giving heated chemotherapy directly into the abdomen during keyhole surgery can increase PD-L1 levels in stomach cancer that has spread to the lining of the belly. PD-L1 is a protein that helps the immune system recognize cancer cells. The goal is to s…

This study looks at whether a special MRI scan that measures muscle health and frailty can help predict serious outcomes like death or the need for a liver transplant in people with liver disease. Researchers will follow 1,200 patients who are already getting an MRI for routine c…

This study looks at whether checking a person's genes before prescribing pain medicine can lead to better pain control for cancer patients. Researchers will give some participants a genetic test and use the results to guide opioid choice, while others receive standard care. The g…

This study tests a computer program that aims to predict when a person with severe traumatic brain injury is about to have dangerous brain pressure or low oxygen levels. About 120 adults in intensive care will be monitored, and the tool's predictions will be checked for accuracy.…

This study looks at how a person's neighborhood resources affect their recovery after knee replacement surgery. Researchers will use a remote monitoring device to track physical progress and compare it to standard care. The goal is to see if remote monitoring can reduce the numbe…

This study looks at why the drug oxytocin sometimes fails to stop heavy bleeding after a C-section. Researchers will measure how the drug moves through the body and how well it makes the uterus contract. About 100 women having planned C-sections will take part. The goal is to fin…

This study looks at whether adding a special scan called PSMA PET to the usual MRI can help find prostate cancer that comes back after focal therapy (a treatment that targets only the tumor). About 62 men who have had focal therapy will get both scans. The goal is to see if the P…

This study collects and stores tissue and blood samples from up to 1,000 people with cancers of the stomach, esophagus, pancreas, liver, gallbladder, and others. The samples are used to create a database and tissue microarrays for future research on how these cancers develop and …

This study looks at why a common gut bacterium, Pseudomonas aeruginosa, becomes deadly in critically ill patients. Researchers will collect stool samples from 100 ICU patients to see how the gut environment triggers the bacteria to turn on their virulence genes. The goal is to un…

This study looks at how often infections occur in broken bones around hip and knee replacements. Researchers will test tissue samples from 200 adults to find out what germs are present and what factors predict infection. The goal is to create clearer guidelines for diagnosing and…