University Of Chicago

This early-stage study is testing whether combining two drugs—Fulvestrant and a radioactive therapy called Lu-DOTATATE—is safe and might help control advanced pancreatic neuroendocrine tumors. The study will enroll about 25 adults whose cancer has spread and has worsened despite …

This study is testing a new training program for primary care clinics called ARISE. The goal is to help doctors and nurses better screen for and address 'diabetes distress'—the unique emotional stress of managing the disease—in adults with type 2 diabetes. Researchers want to see…

This study is testing whether a combination of four drugs is safe and effective for people with multiple myeloma that has returned or stopped responding to standard treatments, including CAR-T cell therapy. About 83 adults whose cancer worsened after at least two prior treatment …

This study is testing whether transplanting insulin-producing cells, called islets, from deceased donors is safe for people with type 1 diabetes who have already had a kidney transplant. The goal is to see if this procedure can help patients achieve better blood sugar control wit…

This early-stage trial is testing a new combination of two experimental drugs, tislelizumab and pamiparib, given together with a standard course of chemotherapy and radiation. The goal is to find a safe and effective dose for people whose head and neck cancer has come back after …

This study is testing if a daily low-dose aspirin pill can help prevent heart damage in women who recently had preeclampsia, a serious pregnancy complication. Researchers will check a specific blood marker (Activin A) to identify women at higher risk and then give them either asp…

This study is testing whether a single counseling session with a trusted friend or family member can help people with HIV stay on track with their medical appointments and medication. It will involve 900 people in Chicago and Alabama. The goal is to see if this social support app…

This early-stage trial is testing whether specially designed mixtures of helpful gut bacteria are safe for people hospitalized with serious liver disease. Researchers want to see if these bacterial mixtures can restore a healthier gut environment, which is often damaged in liver …

This study is testing whether adding a new drug called capivasertib to standard chemotherapy works better for adults with acute leukemia or lymphoblastic lymphoma. Researchers will first find the safest dose, then test if the combination helps patients achieve remission with no d…

This early-stage study aims to find out if adding a drug called ruxolitinib to standard chemotherapy is safe and tolerable for adolescents and young adults (ages 18-40) newly diagnosed with a specific, hard-to-treat form of acute lymphoblastic leukemia (ALL). The main goal is to …

This early-stage study aims to find the safest dose of a powerful combination of five chemotherapy drugs for people with advanced cancers of the stomach, pancreas, and related areas. It uses a patient's genetic test results to personalize the dose of one key drug, hoping to reduc…

This early study is testing if a medication called empagliflozin, usually used for diabetes and heart health, can change urine chemistry to help prevent calcium-based kidney stones from forming again. Researchers will give the drug to 32 adults with a history of these stones for …

This study is testing whether using MRI scans to guide radiation treatment can allow doctors to use lower overall radiation doses for prostate cancer. Researchers aim to reduce side effects like bowel problems while still effectively treating the cancer. The trial will enroll 60 …

This study is testing whether combining two drugs, lenvatinib and pembrolizumab, can help control advanced anal or rectal cancer that has spread and is no longer responding to standard chemotherapy. It will involve about 35 adults whose cancer has progressed after initial treatme…

This study is testing whether the over-the-counter anti-inflammatory drug ibuprofen can lower PSA levels in men with elevated readings. High PSA can signal prostate cancer but is often caused by harmless inflammation. Researchers want to see if reducing inflammation with ibuprofe…

This study is testing a shorter, 3-week course of pelvic radiation for women with non-metastatic uterine or cervical cancer who have had surgery. The main goal is to find out if this shorter schedule is safe and tolerable, and to see how it affects patients' quality of life, bowe…

This study is testing whether nitrous oxide (commonly known as laughing gas) can help reduce symptoms of depression. Researchers will give 172 adults with major depressive disorder weekly one-hour breathing sessions of either nitrous oxide or a placebo air mixture for four weeks.…

This study is testing if a medication called semaglutide, which is approved for weight loss, can help people with both obesity and atrial fibrillation (AFib). Researchers want to see if losing weight with this drug can reduce how often AFib occurs and its severity when used along…

This early-stage study is testing a new combination of two drugs, selumetinib and azacitidine, for adults with higher-risk chronic myeloid blood cancers like myelodysplastic syndromes (MDS) and myelofibrosis. The main goal is to find the safest and most effective dose by carefull…

This study aims to see how well a specific chemotherapy combination works for Nigerian women with triple-negative breast cancer, a particularly aggressive form. Researchers will measure how many women have no detectable cancer after treatment and will also look for signals in the…

This study is testing a home-based exercise and education program designed to help physically frail older adults get stronger before they undergo lung surgery. The goal is to see if this 'prehab' program is practical to run and if it helps patients recover better with fewer compl…

This study is testing if a shorter course of radiation therapy is safe for people with multiple myeloma. Instead of the usual 2-3 weeks of daily treatments, researchers want to see if giving higher doses over just 1 to 10 days works as well and is safe. The trial will enroll 30 a…

This study tests whether using patients' genetic information helps doctors personalize chemotherapy doses to reduce side effects while maintaining effectiveness. Researchers will randomly assign 860 cancer patients to either receive genetic-guided dosing or standard care. The goa…

This study is testing the safety and effectiveness of combining two drugs, VS-6766 and cetuximab, for people with advanced colorectal cancer that has a specific genetic change called a KRAS mutation. The study is for people whose cancer has continued to grow despite trying standa…

This study is testing a 6-month program that combines personal coaching with smartphone apps and activity trackers to help young adults lose weight. Researchers want to see if this tech-supported approach is more effective than standard methods. About 140 participants will track …

This study is testing whether elderly men with prostate cancer who have been on long-term hormone therapy can safely stop their treatment. Researchers want to see if their bodies remain in a low-testosterone state without the medication, which could reduce side effects and health…

This study is testing a new treatment approach for people with a specific type of head and neck cancer that is not linked to HPV. The goal is to see if a combination of a new immunotherapy drug (volrustomig) with two standard chemotherapy drugs can shrink tumors before patients r…

This early-stage study is testing whether an experimental drug called LP-118 can be safely combined with an approved leukemia drug, ponatinib, and standard chemotherapy. The goal is to find the safest and most effective dose for patients whose T-cell acute lymphoblastic leukemia …

This study is testing if a temporary spinal cord stimulator can help people with type 2 diabetes who have painful nerve damage in their legs. Researchers want to see if the device not only reduces pain but also improves blood circulation and artery health in the lower limbs. The …

This study is testing whether Astepro, a common allergy nasal spray, can help control early COVID-19 infection. Researchers will give the spray or a placebo to 280 vaccinated adults who just tested positive but have only mild or no symptoms. They will measure if the spray reduces…

This study is testing whether adding two new, experimental drugs (HB-201 and HB-202) to standard chemotherapy can better shrink tumors in people with HPV16-positive throat cancer. The goal is to see if this stronger initial treatment allows doctors to safely use less radiation or…

This study is testing a new drug, Tegoprubart, combined with standard medications to see if it can safely help transplanted islet cells survive and produce insulin in people with severe type 1 diabetes. The goal is to reduce or eliminate the need for insulin injections and preven…

This study aims to find out if people with ulcerative colitis who are in deep remission can safely reduce or stop their medication without the disease coming back. Researchers will follow 200 patients for two years, comparing those who continue their usual treatment to those who …

This study is testing a new treatment approach for HPV16-positive throat cancer that has not been treated before. Patients first receive an immunotherapy drug (toripalimab) combined with chemotherapy to shrink the tumor. Based on how well the tumor responds, patients then undergo…

This study is developing and testing a mobile phone app designed to help young adults quit or reduce their use of e-cigarettes (vaping). Researchers at the University of Chicago are recruiting 46 people aged 18-26 who vape frequently and want to cut back. The goal is to see if th…

This study is testing if a 'smart' knee implant that tracks movement at home can help people recover better after knee replacement surgery. Researchers want to see if this remote monitoring can safely reduce the number of follow-up doctor visits needed. They will also check if wh…

This study is testing a new approach for treating advanced head and neck cancer that has returned or spread. Researchers want to see if using a simple blood test to measure tumor DNA can help decide when to add short bursts of chemotherapy to standard immunotherapy. The goal is t…

This study is testing a new surgical technique called PoRSHA for repairing large or recurring paraesophageal hernias. The technique uses a flap of the patient's own abdominal wall tissue to reinforce the repair, aiming to make it stronger and more durable than standard methods. R…

This study is testing if a shorter 3-day test period works as well as the standard 7-day test for a bladder control device. The device, called sacral neuromodulation, helps women with overactive bladder symptoms like sudden urges and frequent urination. Researchers want to see if…

This study is testing if two cancer drugs (nivolumab and pembrolizumab) can be given less often while still working effectively. It will compare the standard dosing schedule to a new, less frequent schedule in adults with advanced or metastatic cancer. The main goal is to see if …

This study aims to find out if using the blood pressure drugs phenylephrine and vasopressin is better than the standard drugs norepinephrine and epinephrine for adults in the ICU with shock. The main goal is to see if the new drug combination causes fewer dangerous fast heart rhy…

This study is testing if an implanted nerve stimulator used to treat sleep apnea can also improve blood sugar control and reduce risk factors for heart disease. It will involve 30 adults with moderate-to-severe sleep apnea who cannot use the standard CPAP mask therapy. Researcher…

This study is testing the safety of transplanting insulin-producing cells into adults with severe, hard-to-control Type 1 diabetes. The goal is to help the body better manage blood sugar levels and reduce dangerous episodes of very low blood sugar. Researchers are giving cells fr…

This study is testing if adding a short, intense course of targeted radiation to standard immunotherapy and chemotherapy helps people with extensive-stage small cell lung cancer live longer without their cancer getting worse. It is for adults newly diagnosed with this aggressive …

This study is testing if a new type of surgical rod that allows tiny, controlled movement at the break helps broken shin bones heal better than a standard, rigid rod. Researchers will randomly assign 372 adults with unstable tibia fractures to receive one of the two rod types. Th…

This study is testing two support programs to help people who have been involved with the justice system access HIV care, prevention services like PrEP, and employment. Researchers want to see if adding an employment navigator and small financial incentives to a basic health navi…

This study compares two approaches to radiation treatment for brain tumors that have spread from other cancers. Researchers want to see if using no extra margin around the tumor (0 mm) works as well as the standard 2 mm margin at keeping tumors from growing back. The goal is to c…

This study is testing a targeted cancer treatment approach for Nigerian women with HER2-positive breast cancer. Participants receive a combination of targeted drugs and chemotherapy both before and after surgery. The research aims to see how effective and safe this treatment is f…

This study is testing a procedure called HIPEC, where heated chemotherapy is washed directly into the abdomen during surgery, for people with stomach cancer that has spread to the abdominal lining. The main goal is to see if this treatment makes the cancer cells more visible to t…

This early-stage study is testing the safety and best dose of two drugs, ivosidenib and ruxolitinib, when used together. It is for adults with advanced blood cancers (called myeloproliferative neoplasms) that have a specific genetic change (IDH1 mutation). The main goal is to see…

This study is testing whether a simpler surgical procedure called hiatal closure can effectively control GERD symptoms. Researchers are enrolling 40 adults with early-stage GERD to see if closing the opening in the diaphragm alone (without additional wrapping procedures) can stop…

This early-stage study is testing a new combination of three drugs for people with advanced head and neck cancer that has returned or spread. The main goal is to find the safest and most effective dose of the new drug, Zanzalintinib, when given with two existing cancer drugs. Res…

This study is testing a new, quick finger prick test to see if someone has a current or past Toxoplasma infection. Researchers will compare the results of this new test to a standard lab test to see if it's accurate. The goal is to see if this easier test could be used in clinics…

This study aims to improve the early detection of serious kidney injury in hospitalized adults. Researchers will test whether adding simple blood and urine tests to a computer's risk prediction score makes it more accurate. They plan to enroll 800 patients at high risk for kidney…

This study is testing new computer software designed to help doctors better analyze prostate MRI scans. The software creates detailed maps showing areas most likely to contain cancer, which could help guide biopsy procedures more accurately. Researchers will compare the software'…

This study aims to see if a simple, at-home stool test (called FIT) can be as accurate as colonoscopy for detecting colorectal cancer in people with Lynch syndrome. Lynch syndrome is a genetic condition that greatly increases the risk of colon cancer, requiring frequent colonosco…

This study is testing whether a simple, painless measurement of muscle activity can help doctors diagnose ALS (amyotrophic lateral sclerosis) earlier and more accurately. Researchers will use surface electrodes on the skin to measure how two muscles work together during a simple …

This study is testing a new system to help primary care clinics better identify and manage Post-Traumatic Stress Disorder (PTSD). It will involve screening 17,000 adult patients in Chicago clinics, especially in areas with high rates of trauma. The goal is to see if using patient…

This study is testing whether MRI scans can find aggressive prostate cancers earlier and more often in men at high risk for the disease. Researchers will compare MRI results in high-risk men to those without known risk factors over 15 years. The goal is to improve early detection…

This study aims to help doctors better identify infections when bones break around hip or knee replacements. Researchers will analyze lab tests from 200 patients to understand how often infections occur and what factors predict them. The goal is to create clearer guidelines for d…

This study is testing if adding a special scan called a PSMA PET to the usual MRI can better detect if prostate cancer returns in men who have had focal therapy. Researchers will follow 62 men for about a year after their treatment to compare how well the two scans find returning…

This study is testing a new surgical technique called Immediate Lymphatic Reconstruction (ILR). The goal is to prevent lymphedema, a painful and chronic swelling of the arm that can occur after breast cancer surgery. During the initial cancer operation, surgeons will try to recon…

This study aims to find better ways to catch breast cancer early in women who are at high genetic risk. Researchers will test whether shorter, faster MRI scans work as well as traditional full-length MRIs for regular monitoring. The study will create a registry of 400 high-risk w…

This study is testing if an educational video can help prevent dangerous bloodstream infections in adults who are new to receiving liquid nutrition through a home IV line. Researchers will see if watching the video, which teaches safe catheter handling, leads to fewer infections …

This study aims to help more women at risk for HIV get access to preventive medication (PrEP) at community health clinics. It will test four strategies—training doctors, educating patients, improving clinic computer systems, and providing patient navigation—at 12 clinics in the S…

This study is testing whether applying a special patch soaked with a heart rhythm medicine directly to the heart during surgery can prevent a common and serious complication called atrial fibrillation. The research involves 63 adults having open-heart bypass or valve surgery. Doc…

This study is testing if a special high-fiber, low-fat diet given for 21 days before colon cancer surgery can change the gut's bacteria and environment to help prevent the cancer from returning or spreading. Researchers will provide all meals and track participants' health for up…

This study is testing a new surgical technique called Immediate Lymphatic Reconstruction (ILR). The procedure is done during breast cancer surgery to try to prevent a painful, chronic side effect called lymphedema, which causes severe arm swelling. Researchers will measure arm si…

This study is testing whether a common 'freeze spray' used to numb the skin actually helps reduce pain and anxiety for patients getting steroid injections for joint and tendon problems like arthritis or carpal tunnel. Researchers will enroll 300 adults getting their first injecti…

This study is testing whether adding guided spiritual care sessions to standard hospital care can help adults with acute leukemia feel better during their treatment. Researchers will enroll 70 hospitalized patients and randomly assign them to receive either the special spiritual …

This small pilot study is testing whether a simple ear acupressure technique can boost the benefits of standard pre-surgery exercise programs (prehabilitation) for people facing major lung surgery. Researchers will give 40 participants small seeds to press on specific points of t…

This study is testing whether watching educational videos before bladder removal surgery helps older patients recover better. Researchers want to see if learning strategies from the videos can reduce problems like difficulty moving, medication issues, and poor quality of life aft…

This study compares two common methods for managing pain after carpal tunnel release surgery. Researchers want to see if a machine that provides continuous cooling works better than traditional ice packs. They will measure pain levels and hand function in 128 adults recovering fr…

This study is testing whether nitrous oxide, commonly known as laughing gas, can help reduce the chronic pain of fibromyalgia. Researchers are comparing two 60-minute sessions of inhaled nitrous oxide to a placebo (oxygen-air mixture) in 50 adults with fibromyalgia. The goal is t…

This study is creating and testing a short, personalized counseling program for women going through menopause who have a higher risk of dementia. The goal is to help them manage their fears and learn better ways to cope. Researchers will first talk to women in focus groups, then …

This study aims to find a better way to manage pain after surgery for a broken knee (tibial plateau fracture). Researchers are comparing the standard pain injection around the surgical cut to a different injection that numbs a nerve controlling a larger knee area. The study will …

This study is testing whether giving caffeine can help children wake up faster and feel more alert after being sedated for an MRI scan. Researchers will enroll 100 children aged 3 to 12 and randomly give them either caffeine or a placebo (inactive substance) after their MRI. The …

This study is testing whether putting a numbing medication (bupivacaine) into the bladder right after kidney stone surgery can reduce pain and discomfort. Researchers will compare the medication to a saltwater placebo in 116 adults having this common procedure. The main goal is t…

This study is testing whether a surgery to remove part of the lung lining can help reduce symptoms and improve quality of life for people with advanced pleural mesothelioma that cannot be fully removed. Researchers will follow 30 participants for about 2 years after surgery to tr…

This study is testing whether a 12-week education and support program helps hospitalized African American adults with advanced chronic kidney disease. The program provides information about kidney disease and treatment options, along with follow-up phone calls and text messages f…

This study aims to collect and store tissue and blood samples from patients undergoing surgery or biopsy for various gastrointestinal cancers. Researchers will create a database and tissue samples to help future studies understand how these cancers develop and behave. The goal is…

This study aims to understand the connection between kidney stones, insulin resistance, and inflammation. Researchers will compare 20 people who have had calcium kidney stones with 20 healthy people. They will measure body fat, take blood and urine samples, and analyze them to se…

This study aims to understand how a supplement called potassium citrate affects two natural body chemicals, oxalate and citrate, which are linked to kidney stone formation. Researchers will give the supplement to 24 people—half with a history of kidney stones and half without—and…

This study aims to understand what causes pulmonary fibrosis, a serious disease that scars the lungs. Researchers will collect and examine lung tissue from patients who are receiving a lung transplant, both with and without the disease. By comparing these tissues at a cellular le…

This study aims to understand why the standard drug oxytocin sometimes fails to prevent heavy bleeding after a C-section. Researchers will measure how the drug moves through the body and how its levels relate to the strength of uterine contractions in 100 women having planned C-s…

This study aims to understand how the sleep deprivation from 24-hour hospital shifts affects the immune systems of surgery residents. Researchers will recruit 60 healthy residents to measure changes in their immune cells and inflammation before and after their long shifts. The go…

This study aims to see if a special MRI scan that measures muscle health can help predict which liver disease patients are at higher risk for serious health problems or death. Researchers will add an 8-10 minute scan to the routine MRIs of 1,200 patients at the University of Chic…

This study is testing whether giving doctors genetic information about patients helps them choose safer and more effective pain medications during and after surgery. Researchers are enrolling 1900 adults having elective surgery at the University of Chicago. They will compare outc…

This study aims to understand why a dangerous bacteria called Pseudomonas aeruginosa often grows in the guts of critically ill patients and makes their condition worse. Researchers will collect stool samples from 100 hospitalized patients to analyze how the patient's body chemist…

This study aims to understand how COVID-19 changes gut bacteria in people with long COVID symptoms. Researchers will collect stool and blood samples from 400 people with and without long COVID to identify bacterial differences. The goal is to learn how these changes might contrib…

This study aims to learn how two common food compounds, oxalate and citrate, influence a person's chance of forming kidney stones. Researchers will give 50 participants (25 with a history of stones and 25 without) a single dose of oxalate and then measure changes in their urine a…

This study aims to understand why celiac disease symptoms and gut damage vary so much between people. Researchers will observe 220 adults, including some who eat gluten and some on a gluten-free diet, to see how their bodies react. The goal is to gather information that could lea…

This study aims to find the best way to measure changes after fat grafting surgery for breast or chest wall reconstruction. It will enroll 15 adults who are already planning to have this procedure. Researchers will use different types of imaging, like photos and MRI scans, taken …

This study is testing a computer system designed to predict dangerous pressure and oxygen changes in the brain of patients with severe traumatic brain injury (TBI) before they happen. About 120 patients will have their brain monitor data collected to see if the system's predictio…

This study aims to understand how a patient's heart function relates to their recovery after a severe traumatic brain injury or brain bleed. Researchers will observe 50 adult patients already receiving standard care, using a non-invasive monitor to collect heart and brain pressur…

This study aims to find the specific genes that cause inherited heart and muscle diseases like cardiomyopathy and muscular dystrophy. Researchers will analyze DNA from up to 2,000 patients and their family members who have these conditions. The goal is to better understand the ge…

This study aims to understand how sleep apnea contributes to the development of diabetes. Researchers will study 300 people who have both prediabetes and sleep apnea under different lab conditions to see how their bodies process sugar. The goal is to learn the underlying biologic…

This study aims to understand how obstructive sleep apnea (a condition where breathing stops and starts during sleep) affects blood sugar levels in adults with Type 1 diabetes. Researchers will observe 40 adults who have both conditions, using continuous glucose monitors to track…

This study is creating a large database to track the long-term results and side effects of prostate ablation, a minimally invasive treatment for prostate cancer. It will follow 3,000 men who have had or will have this procedure as part of their regular care. The goal is to gather…

This study is testing whether a weight loss medication called liraglutide (Saxenda) affects brain health markers in people with multiple sclerosis, long COVID, or leukemia in remission who also have obesity and cognitive problems. Researchers will measure changes in a protein cal…

This study is testing different outreach methods to see which ones work best to increase enrollment of African American patients in early-phase cancer treatment trials. It will enroll both patients and their doctors to receive different recruitment approaches or no special outrea…

This study is collecting blood and tissue samples from 500 patients undergoing heart surgery to create a research biobank. The goal is to help scientists better understand how heart diseases develop and progress. This knowledge could lead to improved treatments in the future, but…

This study compares two common tools doctors use to remove temporary blood clot filters from patients' veins. Researchers want to see if one method works better than the other by looking at success rates, procedure time, and safety. The study will help doctors choose the best app…

This study is testing a new system that gives doctors genetic information about their African American patients to help them prescribe medications more safely and effectively. Researchers will see if this system is useful in hospitals and if it specifically improves outcomes for …

This study is testing whether genetic information can help doctors choose safer and more effective medications for their patients. Researchers will collect DNA samples from 1,200 adults receiving routine care at the University of Chicago Medical Center. They will track whether do…

This study is testing a blood test to see if it can detect HPV virus DNA in people with anal or cervical cancer before, during, and after they receive standard radiation treatment. Researchers want to learn if the results of this blood test can help predict whether the cancer mig…

This study is testing a new way to share trustworthy health information online. Researchers are training community health workers in seven high-risk neighborhoods to post personal stories about flu and COVID-19 protection on their social media. The goal is to see if these persona…