University Of Chicago

This study looked at whether a type of diabetes medicine called SGLT2 inhibitors can help people with severe heart failure who also have a mechanical heart pump (LVAD). Researchers measured changes in heart size, weight, and kidney function over 6 months in 32 adults. The goal wa…

This study tested whether giving the immunotherapy drug pembrolizumab for one year after standard treatment could help prevent head and neck cancer from coming back in 100 patients at high risk for recurrence. Participants received either pembrolizumab or a placebo. The main goal…

This study tested a drug called pembrolizumab in 65 people with malignant mesothelioma, a rare cancer of the lining around the lungs or abdomen. The drug works by helping the immune system attack cancer cells. The goal was to see if it could shrink tumors or slow the disease, but…

This phase 2 trial tested a combination of three drugs—carfilzomib, lenalidomide, and dexamethasone—given before and after a stem cell transplant in 76 people newly diagnosed with multiple myeloma. The goal was to see how many patients achieved a very deep remission (stringent co…

This early-phase study tested a new combination of two drugs—enzalutamide and relacorilant—in 42 men with advanced prostate cancer that no longer responds to standard hormone therapy. The main goals were to check safety and see how the drugs interact in the body. Researchers also…

This phase II trial tested whether adding metformin, a common diabetes drug, to standard chemotherapy could help control advanced ovarian, fallopian tube, or primary peritoneal cancer. 111 participants received either metformin or a placebo alongside chemotherapy, followed by mai…

This study tested adding lenalidomide to a standard chemotherapy regimen (EPOCH-R) in 55 people with aggressive B-cell lymphomas linked to the MYC gene. The goal was to find the best dose and see if the combination improves how long patients live without their cancer getting wors…

This small pilot study tested whether adding a prebiotic fiber (a type of plant fiber found in grocery stores) to peanut oral immunotherapy could help children aged 4 to 17 with peanut allergy tolerate more peanut protein with fewer side effects. Twenty children participated, and…

This study tested a mobile app called USeeBP in 31 African American adults with poorly controlled high blood pressure. Participants used the app alongside their usual remote monitoring program to track blood pressure readings at home. The goal was to see if the app could help imp…

This study tested whether metoprolol, an FDA-approved heart medication, can reduce heart damage after surgery in people with coronary artery disease. 72 adults aged 50 and older who were not already on beta-blockers took part. The drug was given after anesthesia and during hospit…

This study looked at 42 people with multiple myeloma that was still present after a stem cell transplant. It compared continuing lenalidomide alone versus adding two other drugs (ixazomib and dexamethasone) to try to eliminate the remaining cancer. The goal was to see which appro…

This phase 2 trial tested a combination of four drugs—elotuzumab, carfilzomib, lenalidomide, and dexamethasone—in 46 people newly diagnosed with multiple myeloma. The goal was to see how many patients achieved a very deep response (stringent complete response or minimal residual …

This study tested a combination of three drugs (pomalidomide, dexamethasone, and carfilzomib) in 25 people with multiple myeloma that had come back or stopped responding to prior treatments. The goal was to find the safest dose and see how well the drugs worked together to contro…

This completed trial tested two programs for older adults with type 2 diabetes: one with monthly phone coaching and one that added personalized referrals to community resources. Over 500 participants were followed for a year to see if these approaches helped lower blood sugar lev…

This pilot study tested a combination of two drugs—belatacept and a proteasome inhibitor—to lower strong immune antibodies in 5 highly sensitized kidney transplant candidates. The goal was to increase their chances of finding a compatible donor. The study has completed, but resul…

This early study tested whether removing a specific type of immune cell (regulatory T cells) is safe in 30 people with multiple myeloma undergoing a stem cell transplant. Participants received standard transplant drugs plus a procedure to deplete these cells. The goal was to see …

This early-phase trial tested a combination of three drugs—selinexor, carfilzomib, and dexamethasone—in 52 patients with multiple myeloma that had returned or stopped responding to treatment. The main goal was to find the safest dose and check for side effects. Researchers hope t…

This study tested a standardized care plan to protect the right side of the heart after a left ventricular assist device (LVAD) implant. Twenty adults receiving an LVAD were given either the standardized care or usual care. The goal was to see if the new approach could prevent ri…

This study looked at whether getting more sleep or keeping a regular bedtime could improve how the body handles sugar and insulin in overweight adults who usually sleep less than 7 hours a night. Eighteen African American men and women aged 21-50 were asked to either extend their…

This study tested four practical strategies—training providers, educating patients, improving electronic health records, and offering patient navigation—to increase use of HIV prevention pills (PrEP) among Black women. Over 700 women from 12 community clinics in the Midwest and S…

This study looked at whether taking different amounts of vitamin D could lower the risk of getting COVID-19. About 1,475 adults from the Chicago area took either a low (400 IU), moderate (4,000 IU), or high (10,000 IU) daily dose of vitamin D for 9 months. Researchers tracked who…

This study looked at whether taking a moderate dose (4,000 IU) of vitamin D daily could lower the chance of getting COVID-19 compared to a low dose (400 IU). Over 2,000 adults in the US took part for 12 months. The goal was to see if vitamin D can help prevent COVID-19 infection.

This study tested whether Caplyta (lumateperone), a drug already used for other mental health conditions, can reduce symptoms of borderline personality disorder (BPD). Sixty adults with BPD received either Caplyta or a placebo pill for 8 weeks. Researchers measured changes in BPD…

This study looked at whether taking fat from one part of the body and moving it to a breast that was damaged by radiation can help the tissue heal. Ten women who had radiation for breast cancer took part. The goal was to see if this fat transfer could make the skin softer and les…

This study tested a program called SIESTA-Rehab to help stroke patients sleep better during their hospital stay. The program included training nurses to reduce nighttime disruptions and a plan to check for and treat sleep apnea. Researchers studied 400 adults in a rehab hospital …

This small study tested whether Epidiolex (a prescription CBD oil) can safely reduce symptoms of obsessive-compulsive disorder, hair-pulling, Tourette syndrome, and hoarding. Four adults took the drug for two weeks. The goal was to see if symptoms improved and if the drug was wel…

This study looked at 70 women having robotic surgery for pelvic organ prolapse. It compared standard gas pressure (15 mmHg) to a slightly lower pressure (12 mmHg) during the operation. The main goal was to see if the lower pressure led to less pain right after surgery, without ma…

This study tested whether a special pain scale called PAINAD, built into the electronic health record, helps emergency room staff better assess and treat pain in older adults with dementia who come in with hip pain. The study included 714 patients and measured how often the scale…

This small Phase 2 trial tested a single 25mg dose of psilocybin in 9 adults with both major depressive disorder and borderline personality disorder. Researchers measured changes in depression and BPD symptoms over time. The goal was to see if psilocybin is safe and could help ea…

This small study tested whether an AI-powered virtual reality app could safely provide mental health support to 22 adults with inflammatory bowel disease (IBD) who also had mild anxiety or depression. The goal was to see if the digital session was practical and acceptable, not to…

This study tested whether a special cooling pillow pad called Moona can help African American adults with overweight or obesity sleep better. 18 participants used either the active cooling pad or an inactive version for 22 days. Researchers measured sleep quality, timing, and blo…

This study gathered information from routine medical care for 198 adults with atrial fibrillation who had a prior procedure to close a small heart pouch (left atrial appendage occlusion) and later needed a heart ablation. Researchers looked at patient details, procedure steps, bl…

This study tested whether an educational video on safe catheter care could reduce bloodstream infections in adults starting home parenteral nutrition for the first time. Twenty-five participants received the video training alongside standard care. Researchers tracked infection ra…

This study looked at whether an educational session about orchiectomy (surgery to remove the testicles) would make more men with prostate cancer choose it over lifelong hormone therapy. 101 men who were already on hormone therapy for at least a year took part. The goal was to see…

This study gathered information from 383 people with slow heartbeats or heart failure who received a special type of pacemaker called conduction system pacing. Researchers looked at how well the device worked, any complications, and changes in heart function over 12 months. The g…

This study looked at how daily rhythms—like sleep and meal timing—affect fat cell genes and insulin response in 28 women with obesity scheduled for bariatric surgery. Researchers used timed lights and meals to align or disrupt the body's internal clock, then measured changes in f…

This study looked at whether offering genetic counseling by phone or video could help more childhood cancer survivors get genetic testing. About 391 survivors took part, comparing remote counseling to usual care. The goal was to see if remote services increase testing uptake and …

This study looked at 66 ICU patients on breathing machines to see if ultrasound could measure diaphragm thickness differently depending on the machine's settings. Researchers compared two modes: one where the machine controls all breaths and one where the patient triggers some br…