University Of Chicago

This early-stage trial tested the safety and dosing of a new two-drug combination for men with advanced prostate cancer that has spread and is no longer responding to standard hormone-blocking treatments. The study combined an existing prostate cancer drug (enzalutamide) with an …

This study aimed to find the best way to protect the right side of the heart after patients with heart failure get a mechanical pump (LVAD) implanted on the left side. It compared two different post-surgery care plans in 20 patients to see which one better prevented weakness in t…

This study tested whether giving the common heart medication metoprolol right after surgery and for a few days in the hospital could reduce heart-related injuries in patients with coronary artery disease. It involved 72 patients who were not already taking similar medications. Pa…

This completed Phase 2 trial tested a combination of four medications (elotuzumab, carfilzomib, lenalidomide, and dexamethasone) as the first treatment for 46 adults newly diagnosed with multiple myeloma, a cancer of plasma cells. The main goal was to see how many patients achiev…

This small pilot study tested whether a combination of two drugs (belatacept and a proteasome inhibitor) could safely help patients who are 'highly sensitized'—meaning their immune systems are primed to reject most donor kidneys—find a compatible donor. The goal was to lower thei…

This early-stage trial tested a new combination of three drugs (selinexor, carfilzomib, and dexamethasone) for patients with multiple myeloma that had returned or stopped responding to previous treatments. The main goals were to find the safest dose and understand side effects in…

This study tested a one-year program to help older adults better manage their type 2 diabetes from home. Over 500 participants received phone calls from nurses to set personal health goals and were connected to local community resources. The goal was to improve daily life and red…

This study tested if adding two more drugs (ixazomib and dexamethasone) to a standard maintenance drug (lenalidomide) was better at controlling residual multiple myeloma after a stem cell transplant. It involved 42 patients who still had small amounts of cancer detectable after t…

This study tested whether adding a common dietary fiber supplement to standard peanut allergy treatment helps children better tolerate small amounts of peanut. Researchers enrolled 20 children aged 4-17 to see if the fiber reduced treatment side effects and improved outcomes by p…

This study tested whether adding a special smartphone app could help African American adults with poorly controlled high blood pressure. The app connected to a home blood pressure cuff, sent readings to doctors, and provided medication reminders and health tips. Researchers wante…

This study tested whether the medication Caplyta could help reduce symptoms of borderline personality disorder (BPD). Sixty adults with BPD took either Caplyta or a placebo pill daily for eight weeks while continuing their regular therapy. Researchers measured whether those takin…

This study tested whether adding a drug called carfilzomib to two existing medications (pomalidomide and dexamethasone) could help control multiple myeloma in patients whose cancer had returned or stopped responding to previous treatments. The trial involved 25 adults who had alr…

This study looked at whether a type of diabetes medication could help people with severe heart failure who have a mechanical heart pump (LVAD). Researchers wanted to see if the drug could reduce fluid buildup and strain on the heart, potentially leading to fewer hospital readmiss…

This small, early-stage study tested whether temporarily removing a specific type of immune cell, called a regulatory T cell, during a patient's own stem cell transplant could be done safely for people with multiple myeloma. The goal was to see if this change might help the immun…

This study aimed to see if taking higher daily doses of vitamin D could help prevent people from getting COVID-19. Researchers in Chicago enrolled nearly 1,500 adults and randomly assigned them to take either a standard low dose (400 IU) or a much higher dose (4,000 or 10,000 IU)…

This small pilot study explored whether improving sleep could lower the risk of developing diabetes and obesity. Researchers worked with 18 overweight Black adults who were short sleepers, having them either extend their nightly sleep by about 2 hours or stick to a very regular s…

This study tested whether taking a higher daily dose of vitamin D (4,000 IU) could prevent COVID-19 infections better than a standard low dose (400 IU). Over 2,000 adults across the United States participated from home, taking their assigned vitamin D dose daily and completing su…

This study tested whether improving sleep for people recovering from a stroke in the hospital could help them get better faster. Researchers worked with 400 stroke patients during their rehab stay. They trained hospital staff to reduce nighttime disruptions and screened patients …

This small, exploratory study tested a single session using a virtual reality app with an AI-powered guide to provide mental health support. It involved 22 adults with inflammatory bowel disease (IBD) who also had mild to moderate anxiety or depression. The main goal was to see i…

This small, early-stage study tested whether a prescription CBD medication (Epidiolex) could safely reduce symptoms in adults with obsessive-compulsive disorder (OCD) and related conditions like hair-pulling and hoarding. Four participants took the medication for two weeks while …

This small, completed pilot study tested whether a cooling pillow pad could improve sleep quality and related metabolic health in African American adults with overweight or obesity. Researchers wanted to see if this non-drug approach could help people fall asleep faster, sleep be…

This study tested whether a simple checklist could help emergency room staff better recognize and treat pain in people with dementia. Researchers enrolled 714 older adults with dementia who came to the ER with hip pain. They checked if prompting doctors to use a special pain obse…

This study tested if using slightly lower air pressure inside the abdomen during a specific type of robotic pelvic surgery could reduce patients' pain after the operation. Researchers compared the standard pressure to a lower pressure in 70 women having the surgery. The goal was …

This small, completed study from the University of Chicago explored whether a single dose of psilocybin, the active compound in 'magic mushrooms,' could safely reduce symptoms in adults diagnosed with both major depression and borderline personality disorder. Nine participants re…

This international registry collected information from 383 patients who received specialized pacemakers for slow heart rhythms or heart failure. Researchers tracked how doctors used new pacing techniques in real-world practice to understand their benefits and limitations. The goa…

This study tested whether providing education about surgical castration (removing the testicles) would make more men with advanced prostate cancer choose this surgery over continuing lifelong hormone-blocking injections. Researchers enrolled 101 men already receiving long-term ho…

This study aimed to understand why weight loss surgery improves the body's ability to manage blood sugar so quickly, often before significant weight loss occurs. Researchers studied 28 women, comparing fat cells from those with and without obesity before and after surgery. They l…

This study aimed to understand how a patient's main breathing muscle, the diaphragm, changes when a breathing machine is set to different modes. Researchers used ultrasound to measure diaphragm thickness in 66 ICU patients on ventilators, comparing machine-controlled breathing to…

This study tested whether providing genetic counseling remotely by phone or video could help childhood cancer survivors access recommended genetic testing. Researchers compared this remote approach to usual care options to see if it increased how many survivors got tested or rece…

This phase I/II trial studies the side effects and best dose of lenalidomide when given together with combination chemotherapy and to see how well they work in treating patients with v-myc myelocytomatosis viral oncogene homolog (avian) (MYC)-associated B-cell lymphomas. Lenalido…