University Of Chicago

This study tested the drug pembrolizumab in 65 people with malignant mesothelioma, a rare cancer of the lining around the lungs or abdomen. The drug works by helping the immune system attack cancer cells. The goal was to see if it could control the disease in patients whose cance…

This early-phase study tested a combination of three drugs (selinexor, carfilzomib, and dexamethasone) in 52 adults with multiple myeloma that had returned or stopped responding to prior treatments. The main goal was to find the safest dose and identify side effects. Researchers …

This study looked at whether a type of diabetes medicine called SGLT2 inhibitors can help people with severe heart failure who also have a mechanical heart pump (LVAD). Researchers measured changes in heart size, weight, and kidney function over six months in 32 adults. The goal …

This study tested a combination of the drug lenalidomide with standard chemotherapy (called DA-EPOCH-R) in 55 people with a fast-growing type of B-cell lymphoma linked to the MYC gene. The goal was to find the safest dose and see if the combo helps keep the cancer from growing or…

This study tested a combination of three drugs (pomalidomide, dexamethasone, and carfilzomib) in 25 people whose multiple myeloma had returned or stopped responding to prior treatments. The goal was to find the safest dose and see how well the drugs worked together. Results helpe…

This study tested a new combination of two drugs (belatacept and a proteasome inhibitor) in 5 highly sensitized kidney transplant candidates. The goal was to lower their strong immune antibodies so they could find a compatible donor. The approach aims to safely increase the chanc…

This study tested whether adding metformin (a common diabetes drug) to standard chemotherapy could help people with advanced ovarian, fallopian tube, or primary peritoneal cancer. About 111 participants received either metformin or a placebo alongside chemo, then continued metfor…

This study tested whether remote support—like phone check-ins and connecting people to community resources—could help older adults with type 2 diabetes better manage their condition. Over 500 participants received personalized goal-setting and care coordination for 12 months. The…

This study tested whether giving metoprolol, an FDA-approved heart medication, right after surgery and during hospital recovery can reduce heart damage in people with coronary artery disease. Researchers monitored daily blood tests for signs of heart injury in 72 older adults. Th…

This early-stage study tested a new drug combination for men with advanced prostate cancer that no longer responds to standard hormone therapy. The trial included 42 participants and aimed to see if adding relacorilant to enzalutamide is safe and can help control the disease. Res…

This study looked at whether helping people sleep longer or on a more regular schedule could improve their metabolic health and lower their risk for diabetes and obesity. Researchers studied 18 overweight adults who typically slept less than 7 hours a night. Over 24 days, they tr…

This study looked at 42 people with multiple myeloma that remained after a stem cell transplant. It compared taking lenalidomide alone versus adding two other drugs (ixazomib and dexamethasone) to see if the combo could better clear the leftover cancer. The goal was to find a mor…

This study tested a three-drug combination (carfilzomib, lenalidomide, and dexamethasone) given before and after a stem cell transplant in 76 people newly diagnosed with multiple myeloma, a type of blood cancer. The goal was to see how well the treatment could control the disease…

This study tested a smartphone app called USeeBP to help African American adults with poorly controlled high blood pressure. 31 participants used the app alongside their usual care. The goal was to see if the app could help lower blood pressure readings.

This study tested a combination of four drugs (elotuzumab, carfilzomib, lenalidomide, and dexamethasone) in 46 people newly diagnosed with multiple myeloma, a blood cancer. The goal was to see how many patients achieved a very deep remission (stringent complete response or minima…

This study tested whether taking a moderate dose of vitamin D (4,000 IU daily) could lower the chance of getting COVID-19 compared to a low dose (400 IU daily). Over 2,000 adults from the Chicago area and other US communities took part. Participants reported any COVID-19 infectio…

This study looked at whether taking moderate (4,000 IU) or high (10,000 IU) doses of vitamin D daily could lower the risk of getting COVID-19 compared to a low dose (400 IU). About 1,475 adults from the Chicago area took part for 9 months. Researchers tracked who got a confirmed …

This study looked at 70 women having robotic surgery for pelvic organ prolapse. It compared standard gas pressure (15 mmHg) to a slightly lower pressure (12 mmHg) during the operation. The goal was to see if lower pressure leads to less pain right after surgery, without making it…

This study tested whether the drug Caplyta (lumateperone) can reduce symptoms of borderline personality disorder (BPD). Sixty adults with BPD were randomly assigned to take either Caplyta or a placebo pill every day for 8 weeks. Researchers measured changes in BPD symptoms and ag…

This small study tested whether taking fat from one part of the body and moving it to a breast that was damaged by radiation could improve skin health. Ten women who had radiation for breast cancer took part. The goal was to see if this fat transfer could make the skin softer and…

This small study tested a single dose of psilocybin, the active ingredient in magic mushrooms, in 9 adults with both major depression and borderline personality disorder. Researchers measured changes in depression and BPD symptoms over time to see if the treatment was safe and he…

This early study tested the drug Epidiolex (a form of cannabidiol) in 4 adults with obsessive-compulsive disorder, hair-pulling, Tourette syndrome, or hoarding. Participants took the drug for two weeks, and researchers tracked changes in symptoms using standard rating scales. The…

This pilot study tested whether adding a common fiber supplement (prebiotic) to peanut oral immunotherapy helps children with peanut allergy tolerate more peanut protein with fewer stomach side effects. Twenty children aged 4 to 17 participated. The goal was to see if the fiber m…

This small study tested whether a digital wellness app using artificial intelligence and virtual reality could safely provide mental health support to adults with inflammatory bowel disease who also have mild anxiety or depression. Twenty-two participants used the app during a si…

This study tested a special cooling pillow pad called Moona to see if it could help African American adults with overweight or obesity sleep better. 18 people took part. The goal was to measure changes in sleep quality and related health markers like blood sugar control. The stud…

This study looked at how daily rhythms affect fat cell genes and insulin response in 28 women with severe obesity scheduled for bariatric surgery. Researchers measured changes in fat cell insulin sensitivity before and 12 weeks after surgery. The goal was to understand the body's…

This study tested whether an educational video on safe catheter care could reduce bloodstream infections in adults starting home parenteral nutrition for intestinal failure. 25 first-time users watched the video and were monitored for infection events. The goal was to see if simp…

This study looked at whether offering genetic counseling and testing remotely can help childhood cancer survivors get the genetic services they need. About 391 survivors took part, and the goal was to see if more people would complete genetic testing or counseling with this appro…

This study tested a program to improve sleep for 400 stroke patients in rehabilitation. The program trained nurses to reduce nighttime disruptions and screened patients for sleep apnea. The goal was to see if better sleep could improve recovery and daily function.

This study tested whether a special pain scale called PAINAD helps emergency room staff better assess and treat pain in people with dementia. Over 700 older adults with dementia and hip pain took part. The goal was to see if using this tool leads to quicker and more accurate pain…

This study looked at whether teaching men with advanced prostate cancer about orchiectomy (surgery to remove the testicles) would make them more likely to choose it over lifelong hormone therapy. 101 men who were already on hormone therapy for at least a year took part. The goal …

This early-phase study looked at whether it is safe and possible to remove a specific type of immune cell (regulatory T cells) in 30 people with multiple myeloma who were getting a stem cell transplant using their own cells. The goal was to see if this removal could be done effec…

This study looked at ways to protect the right side of the heart after patients receive a mechanical pump (LVAD) for heart failure. Twenty adults who had LVAD surgery were monitored closely for several days. The goal was to find better methods to prevent right heart problems afte…

This study observed 66 ICU patients on mechanical ventilators to see if ultrasound measurements of the diaphragm differ between two breathing modes. Researchers measured diaphragm thickness during controlled and spontaneous breaths, and also during a sedation pause. The goal was …

This study collected information from 383 people with slow heartbeats or heart failure who received a special type of pacemaker called conduction system pacing. The goal was to see how well this pacing method works in everyday medical practice around the world. Researchers tracke…