University Of Chicago

This study tested the drug pembrolizumab in people with a hard-to-treat type of lymphoma (DLBCL) that has certain gene changes (PD-L1 alterations). The goal was to see if the drug could shrink tumors. However, the study was stopped early and only 5 people took part, so the result…

This study looked at whether taking a pill containing gut bacteria (EDP1503) could make standard immunotherapy (pembrolizumab) work better for people with advanced melanoma. The study planned to include two groups: those new to immunotherapy and those whose cancer had stopped res…

This study tested a combination of two drugs—pembrolizumab (an immunotherapy) and mifepristone (a hormone blocker)—in people with advanced HER2-negative breast cancer. The goal was to see if the combination could shrink tumors. The study was stopped early after enrolling 24 parti…

This study tested whether a lower dose of the drug tocilizumab could help hospitalized COVID-19 patients with lung inflammation recover faster. The trial included 85 adults who were not on a breathing machine. Researchers compared two low doses (40mg and 120mg) to standard care, …

This study tested a new drug called xevinapant combined with chemotherapy and radiation for people with head and neck cancer who cannot take the standard drug cisplatin. The goal was to find the safest dose and see how well the combination works. The study was stopped early, but …

This study aimed to find the lowest effective dose of the prostate cancer drug abiraterone for men starting treatment. Researchers planned to enroll 50 men and test different doses over 12 weeks, measuring hormone levels and PSA. The study was terminated early, so results are lim…

This study tested a new, fast, and low-cost MRI method to screen for breast cancer in women with dense breasts or moderate risk. The goal was to see if this MRI could find cancers earlier and more accurately than standard mammograms. The study was stopped early, but it aimed to r…

This study looked at adults with a broken thigh bone (femur) who needed surgery within 24 hours. Researchers wanted to see if applying gentle traction (pulling) to the leg before surgery made the operation easier, reduced pain, and lowered blood loss. The study was stopped early,…

This study tested whether letting heart surgery patients manage their own recovery (self-managed sternal precautions) leads to better quality of life than following standard strict precautions. Researchers enrolled 10 adults who had chest-opening heart surgery and tracked pain, r…

This study aimed to see if taking glutathione by mouth is safe and practical for children and teens with autism spectrum disorder. Researchers planned to include 24 participants but stopped early with only 6 enrolled. The supplement was given for 12 weeks to check for changes in …

This study aimed to find a genetic link or family trait that causes Hidradenitis Suppurativa (HS), a painful skin condition. Researchers collected DNA from 97 people with HS and their family members to search for rare gene changes. The goal was to better understand the cause of H…

This study looked at why some people with multiple myeloma develop shortness of breath when taking the drug carfilzomib. Researchers used an FDA-approved device to check blood vessel health and see if it relates to breathing problems. The goal was to better understand and prevent…