University Of Chicago

This early-stage trial is testing whether adding the drug ruxolitinib (Jakafi) to standard chemotherapy is safe for adolescents and young adults (ages 12-39) newly diagnosed with Ph-like acute lymphoblastic leukemia (ALL), an aggressive subtype. The study will enroll 15 participa…

This study tests whether adding targeted radiation to immunotherapy can help control advanced non-small cell lung cancer better than standard chemotherapy. It is for patients whose cancer has worsened after previous immunotherapy. About 39 adults will be randomly assigned to one …

This study tests whether lactulose, a type of sugar, can make immunotherapy more effective for people with advanced cancer. About 55 participants will take lactulose alongside their standard immunotherapy to see if it increases helpful gut bacteria and improves tumor shrinkage. T…

This phase 2 trial is testing whether combining focal prostate ablation (a surgery that destroys only the cancerous part of the prostate) with a short course of hormone therapy can effectively treat intermediate-risk prostate cancer. The study will enroll 57 participants and meas…

This study tests whether regularly screening for diabetes-related emotional distress and offering support can improve blood sugar control in adults with type 2 diabetes. About 1,250 participants with high blood sugar (A1C over 8%) will take part. The goal is to see if addressing …

This study tests a new chemotherapy-free treatment for adults with a specific type of leukemia called Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The treatment combines three drugs: inotuzumab ozogamicin, dasatinib, and dexamethasone. The goal is to s…

This study tests a new drug called tegoprubart along with other medicines to help people with type 1 diabetes and chronic kidney disease receive pancreatic islet cell transplants. The goal is to see if this approach is safe and can improve blood sugar control without needing life…

This phase 2 study tests whether adding occasional chemotherapy to the immunotherapy drug pembrolizumab (Keytruda) can improve outcomes for people with recurrent or metastatic head and neck cancer. A blood test that measures tumor DNA helps doctors decide when to give the chemo. …

This study tests whether taking a daily low-dose aspirin for six months after childbirth can improve heart function in women who had preeclampsia. Preeclampsia can raise a protein called Activin A, which may harm the heart. The trial will compare aspirin to a placebo in 180 women…

This study tests whether combining two drugs, lenvatinib and pembrolizumab, can shrink or control advanced anal or rectal cancer that has spread and stopped responding to standard chemotherapy. About 35 adults with this type of cancer will receive the drug combination. The goal i…

This study tests whether having a trusted friend or family member (a Support Confidant) can help people with HIV keep their medical appointments and lower their virus levels. Researchers will enroll 900 people aged 18-49 in Chicago and Alabama who have missed visits or had unsupp…

This phase 2 trial is testing whether a single low dose of tocilizumab, a drug that blocks inflammation, can help people with sickle cell disease who develop acute chest syndrome—a serious lung complication. Researchers will enroll 200 patients aged 12 and older and track their o…

This study tests a new drug called LP-118 combined with three existing cancer medicines (ponatinib, vincristine, and dexamethasone) in adults with T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma that has come back or not responded to treatment. The goal is to…

This study tests whether using MRI scans to guide radiation can lower the dose to healthy parts of the prostate while targeting cancer spots. The goal is to reduce bowel-related side effects without losing cancer control. About 60 men with intermediate- or high-risk prostate canc…

This early-phase trial tests a combination of two newer drugs (tislelizumab and pamiparib) plus standard chemotherapy and re-radiation in 30 people whose head and neck cancer has come back. The main goal is to find a safe dose and check for side effects. Participants will be foll…

This study tests a new drug called volrustomig combined with standard chemotherapy (paclitaxel and carboplatin) in people with advanced head and neck cancer that is not caused by HPV. The goal is to see if this combination shrinks tumors before further treatment is tailored based…

This study is for people newly diagnosed with extensive-stage small cell lung cancer that has spread. Researchers want to see if adding a precise, high-dose radiation treatment (ablative radiation) to the standard combination of durvalumab (an immunotherapy) and chemotherapy (car…

This study tests whether adding a drug called relacorilant to standard hormone therapy and enzalutamide can better shrink high-risk prostate cancer before surgery. About 90 people whose cancer has not responded to standard treatments will take the study drugs for 24 weeks, then h…

This study tests whether a lab-made antibody called Tegoprubart can safely prevent the immune system from attacking transplanted islet cells in people with type 1 diabetes who have dangerous low blood sugar. The goal is to help patients stop needing insulin without using standard…

This study tests whether adding the experimental drug capivasertib to a standard treatment (venetoclax plus low-intensity chemotherapy) is safe and effective for adults with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma that has come back or not responded to prior …

This study tests a specific chemotherapy combination (epirubicin + cyclophosphamide followed by docetaxel + carboplatin) in 85 Nigerian women with triple-negative breast cancer. The main goal is to see how many women have no cancer left in their breast or lymph nodes after treatm…

This phase 2 trial is testing a combination of anti-HER2 drugs (trastuzumab emtansine, pertuzumab, and docetaxel) plus hormone therapy (tamoxifen or letrozole) given before and after surgery in 74 Nigerian women with HER2-positive breast cancer. The main goal is to see if the can…

This Phase 2 trial is testing whether giving the immunotherapy drug toripalimab along with standard chemotherapy before surgery or radiation can shrink HPV16-positive oropharyngeal (throat) tumors by at least 50%. The study enrolls 30 patients with advanced but localized disease.…

This study looks at a new surgical method called PoRSHA for repairing large or recurrent paraesophageal hernias. The technique uses a flap made from the patient's own abdominal lining to reinforce the diaphragm opening, aiming to reduce hernia recurrence. About 100 adults with he…

This study tests whether surgically closing the hiatal opening can control gastroesophageal reflux disease (GERD) in people with early-stage disease. Researchers will enroll 40 adults aged 18-50 with a small hiatal defect and confirmed acid reflux. The main goal is to see if the …

This study tests four different drugs (norepinephrine, epinephrine, phenylephrine, and vasopressin) in ICU patients with shock that doesn't improve with fluids. The goal is to see which drug causes fewer dangerous heart rhythm problems and improves survival. About 836 adults will…

This early-phase study tests whether adding the drug fulvestrant to standard radiation therapy (Lu-DOTATATE) is safe and helps shrink tumors in people with advanced pancreatic neuroendocrine tumors. About 25 adults whose cancer has spread or cannot be removed by surgery will take…

This early-phase study tests a combination of two drugs, selumetinib and azacitidine, in adults with higher-risk blood cancers like MDS and myelofibrosis. The main goal is to find the safest dose of selumetinib when given with standard azacitidine and to monitor side effects. Par…

This Phase 2 study tests a combination of four drugs—belantamab mafodotin, carfilzomib, pomalidomide, and dexamethasone—in people with multiple myeloma that has returned or stopped responding to treatment. The goal is to see if this mix can shrink tumors or slow the disease. Abou…

This study tests whether transplanting insulin-producing islet cells from deceased donors can help people with brittle type 1 diabetes achieve safer blood sugar control without insulin shots. Up to 20 adults aged 18–70 with long-standing type 1 diabetes will receive the cells thr…

This phase 2 trial tests whether transplanting insulin-producing islet cells from deceased donors can help people with type 1 diabetes who have already received a kidney transplant. The goal is to achieve safe blood sugar levels without insulin shots. Ten participants will receiv…

This early-stage trial is testing a new three-drug combination for people with head and neck cancer that has come back or spread. The drugs include a targeted therapy (zanzalintinib), an immunotherapy (pembrolizumab), and another targeted antibody (cetuximab). The main goal is to…

This study tests whether combining lifestyle coaching with a smartphone app helps young adults (ages 18-40) who are overweight or obese lose weight. All 140 participants will receive diet and exercise goals and coaching. Researchers will measure weight change after 6 months to se…

This study tests whether semaglutide, a medication used for weight loss, can help control atrial fibrillation (AFib) in people who are overweight or have obesity. About 200 adults aged 18-75 with AFib and a BMI of 30 or higher will receive semaglutide plus standard AFib care. Res…

This early-stage trial tests a combination of two drugs, ivosidenib and ruxolitinib, in people with advanced blood cancers (MPNs) that have an IDH1 mutation. The main goal is to find the safest dose and see if the combo helps control the disease. About 18 adults will take part.

This early-stage trial is testing whether giving a mix of healthy gut bacteria (from donors) to people hospitalized with serious liver disease is safe and tolerable. The study involves 24 adults with liver failure or cirrhosis who have low levels of certain gut metabolites. Resea…

This study tests whether two common cancer immunotherapy drugs (nivolumab and pembrolizumab) can be given less often than the current standard schedule. About 264 adults with advanced or metastatic cancer will be randomly assigned to receive the drugs at standard intervals or ext…

This early-stage trial is testing a powerful mix of five chemotherapy drugs for people with advanced upper gastrointestinal cancers, including pancreatic and stomach cancers. The study uses each person's genetic profile to adjust the dose of one of the drugs (irinotecan) to try t…

This study tests a new software tool that automatically analyzes MRI images of the prostate to find cancer areas that doctors might miss. About 180 people with known or suspected prostate cancer will get an MRI and then a targeted biopsy. Researchers will compare the software's a…

This study enrolls 400 women at high risk for breast cancer to see if a shorter, abbreviated MRI scan works as well as a full-length MRI for early detection. Participants will get MRI scans every 6 months. The goal is to develop faster, personalized screening that could make regu…

This study is testing whether a fecal immunochemical test (FIT), which checks for blood in the stool, can accurately detect colorectal cancer in people with Lynch Syndrome. Lynch Syndrome increases the risk of colorectal cancer, and patients currently need regular colonoscopies. …

This study looks at whether regular MRI scans can find high-grade prostate cancer earlier in men who are at high risk. Researchers will screen 250 men with no prior prostate cancer every 3 years for up to 15 years. The goal is to see if MRI detects aggressive cancers sooner than …

This study is testing whether adding a PSMA PET scan to the usual MRI can better detect prostate cancer that has come back after focal therapy. Focal therapy treats only the cancerous part of the prostate, but cancer can sometimes return. The PSMA PET scan uses a radioactive dye …

This study is testing whether a quick, painless measurement of muscle activity using surface electrodes can help doctors diagnose ALS earlier and more accurately. Researchers will compare this test to current methods in 650 people with muscle symptoms. They will also track how th…

This study is testing a new finger prick device that can detect Toxoplasma infection from a drop of blood. Researchers will compare the device's results to a standard lab test in 210 adults, including pregnant women. The goal is to see if the finger prick test is accurate and eas…

This early-phase study tests whether placing amiodarone directly into the sac around the heart during open-chest surgery can prevent a common and serious irregular heartbeat called atrial fibrillation. About 63 adults aged 20-85 having bypass or valve surgery will receive this tr…

This study tests a surgical technique called immediate lymphatic reconstruction (ILR) done at the same time as lymph node removal for cancer. The goal is to reconnect tiny lymph channels to nearby veins to prevent lymphedema, a painful arm swelling. Researchers will measure arm s…

This study tests whether empagliflozin, a drug used for diabetes and heart conditions, can help prevent calcium-based kidney stones. Researchers will give the drug daily for 4 weeks to 32 adults who have had calcium oxalate or calcium phosphate stones. They will measure changes i…

This study tests a surgical procedure called immediate lymphatic reconstruction (ILR) done at the same time as lymph node removal in breast cancer patients. The goal is to prevent lymphedema, a painful arm swelling that can occur after surgery. Researchers will follow 100 women t…

This study is testing whether eating a high-fiber, low-fat diet for three weeks before colorectal cancer surgery can change gut bacteria to help prevent the cancer from returning or spreading. About 80 adults with colorectal cancer will follow this diet and provide blood, stool, …

This study tests whether daily or weekly text message reminders help adolescents and young adults (ages 15-39) with acute lymphoblastic leukemia (ALL) take their oral chemotherapy medications (mercaptopurine and methotrexate) more consistently during maintenance therapy. Particip…

This study tests a web-based program called OMGYES.com to see if it helps young adult female cancer survivors who have sexual problems. About 30 people will take part, using online modules at home and visiting the clinic every 5 weeks for questionnaires. The goal is to see if the…

This study tests two types of speech therapy for adults with mild-to-moderate primary progressive aphasia, a condition that slowly impairs language. Researchers will compare the therapies in 200 participants to see which better improves communication and reduces caregiver burden.…

This study tests whether wearing a thumb cast for 2 weeks after surgery is as good as wearing it for 6 weeks for people with thumb arthritis. About 90 adults aged 40 and older will be randomly assigned to one of the two recovery plans. Researchers will track pain, hand function, …

This study tests a mobile health app designed to help young adults (ages 18-26) quit using e-cigarettes and other nicotine products. The app delivers personalized motivational messages and skills training over 6 weeks. Researchers will measure if participants stop vaping, confirm…

This early study tests a small device temporarily implanted in the breast during mastectomy. The device sends tiny electrical pulses to nerves to try to restore touch sensation and reduce chronic pain. Only 8 people having both breasts removed will take part, to see if the idea i…

This study partners with community organizations to adapt a smoking cessation program for adults who smoke and receive care at behavioral health clinics. Researchers will enroll 24 participants to test whether the program is feasible and acceptable. The goal is to learn how to be…

This study tests an 8-week, home-based program called SUPPORT for minority women with bladder control problems. It combines counseling, behavior changes, and exercises, with staff support and a custom AI chatbot. The goal is to see if the program is easy to use and helps reduce s…

This study tests if a shorter course of radiation (hypofractionation) is safe for people with multiple myeloma who need pelvic radiation. Instead of the usual 2-3 weeks, the radiation is given over fewer days with slightly higher daily doses. The goal is to find the highest safe …

This study looks at whether adding guided spiritual care sessions to standard hospital care is possible and helpful for adults newly diagnosed with acute leukemia. Seventy participants will be randomly assigned to receive either regular spiritual visits or usual care. The goal is…

This study looks at whether a surgery called partial pleurectomy (removing part of the lung lining) can help with symptoms and quality of life in people with advanced pleural mesothelioma that cannot be fully removed. About 30 participants will have the surgery and fill out sympt…

This study looks at whether a 3-day trial of a nerve-stimulating device for bladder control works as well as the standard 7-day trial. About 193 women with urgent or frequent urination will be randomly assigned to either a 3-day or 7-day test. The goal is to see if the shorter tr…

This study is developing a short, personalized program called PERI-MIND to help menopausal women who are worried about dementia. The program includes education about menopause and dementia risk, plus practical skills to cope with fear. Researchers will first hold focus groups to …

This study compares a continuous cooling therapy device to traditional ice packs for managing pain after open carpal tunnel release surgery. About 128 adults having the surgery will be randomly assigned to one of the two cooling methods. Researchers will measure pain levels and h…

This study tests whether a nerve block (numbing medication injected near knee nerves) can control pain better than the usual method of numbing just the surgical cut. Researchers will compare pain scores and painkiller use in 38 adults recovering from surgery for a broken shinbone…

This study tests whether a spinal cord stimulator—a device that sends mild electrical pulses to the spine—can reduce pain and improve blood flow in the legs of people with type 2 diabetes who have nerve pain. Researchers will enroll 25 adults with painful diabetic neuropathy and …

This study is testing whether a shorter course of pelvic radiation (called hypofractionation) is safe for women with endometrial cancer. The researchers will find the best dose and see if it reduces bowel and urinary side effects. About 100 women who have already had surgery will…

This study tests whether a simple, non-invasive ear acupressure technique can help people aged 50 and older feel better and stronger while waiting for lung surgery. Participants will have small seeds placed on their ears and press them daily. The goal is to see if this approach i…

This study tests whether the common anti-inflammatory drug ibuprofen can reduce elevated PSA levels in men. High PSA often leads to prostate biopsies, but inflammation can falsely raise PSA. The trial enrolls 200 men with PSA over 3 ng/mL and no known prostate cancer. Participant…

This study tests whether Astepro, an over-the-counter allergy nasal spray, can help manage early COVID-19 symptoms and reduce viral load. 280 adults with a positive COVID test will use the spray or a placebo for 10 days. Researchers will track symptoms, viral levels, and whether …

This study tests whether placing the numbing drug bupivacaine into the bladder after kidney stone surgery can reduce pain and bladder spasms. About 116 adults will be randomly assigned to receive either the drug or a saltwater placebo. The goal is to see if this simple step impro…

This study tests whether spraying a numbing coolant (ethyl chloride) on the skin before a corticosteroid injection reduces pain and anxiety. 300 adults receiving their first joint or soft-tissue injection will be randomly assigned to get either the freeze spray or a placebo cold …

This study tests whether an educational video program and geriatric discharge planning can help people aged 65 and older with bladder cancer recover better after cystectomy (bladder removal surgery). Participants watch videos on mobility, medication, and mental clarity, and meet …

This study tests whether giving frail adults an Apple Watch and an exercise flipbook can help them get stronger before thoracic surgery. Researchers want to see if patients will use the device and follow the exercises. The goal is to improve recovery and reduce complications afte…

This study tests whether giving caffeine to children after sedation for an MRI scan can help them wake up and recover faster. About 100 children aged 3 to 12 will receive either caffeine or a placebo shortly after their MRI. The goal is to see if caffeine reduces the time it take…

This study compares general anesthesia (given through an IV) with spinal anesthesia (a numbing shot in the back) for people having a knee replacement. The goal is to see which approach allows more patients to go home the same day. Researchers will also track recovery, pain, nause…

This study tests whether giving heated chemotherapy directly into the abdomen (HIPEC) can increase a protein called PD-L1 on stomach cancer cells that have spread to the lining of the belly. Higher PD-L1 levels might make these cancers more responsive to immunotherapy drugs. The …

This study follows 4,000 people with interstitial lung disease (including conditions like pulmonary fibrosis and sarcoidosis) to understand how the disease naturally changes over time. Researchers will collect medical data and blood samples, and compare them to a healthy control …

This study looks at whether offering free legal help to people recovering from violent injuries like gunshot wounds can lower stress and improve their health. Researchers will work with 500 patients at a trauma center to address problems like housing or money issues that often le…

This study tests a new set of procedures called the HI-SPEED Protocol, designed to help hospitals evaluate stroke patients faster and decide who needs to be transferred for advanced care. The goal is to reduce the time patients spend in the first hospital before being moved to a …

This study is creating a registry to track how well a procedure called genicular artery embolization (GAE) works for knee osteoarthritis pain over time. Up to 100 adults with mild to moderate knee arthritis that hasn't improved with standard treatments will be enrolled. The goal …

This study aims to understand why some people develop kidney stones after gastric bypass surgery. Researchers will look at how diet and sex influence urine chemistry. About 28 participants who are scheduled for bariatric surgery will follow a special diet for six days and provide…

This study aims to learn more about how celiac disease damages the gut and how it heals. Researchers will look at gut cells, bacteria, the immune system, and genetics in 220 adults. The goal is to better understand symptoms and improve care for people with celiac disease.

This study follows 60 adults with cirrhosis who are waiting for a liver transplant but do not have diabetes. Researchers want to see if tests like glucose monitoring, oral glucose tolerance tests, and wrist activity trackers can predict who will develop diabetes after the transpl…

This study looks at how a very low dose of LSD (13 micrograms) affects mood and behavior in 48 healthy adults. Some participants will be told exactly what they are getting (LSD or placebo), while others will not know. The goal is to understand whether people's expectations—not ju…

This study looks at whether giving doctors genetic information about their patients can help them choose safer and more effective pain medications. Researchers will enroll 800 cancer patients who are expected to need opioid painkillers. Half will have their genes tested to guide …

This study looks at whether a smartphone app can measure how well older adults (60+) walk before and after major abdominal surgery. Researchers will track walking speed and recovery over time using the app and an accelerometer. The goal is to find a simple way to identify patient…

This study looks at whether giving doctors genetic information about their African American patients can help them prescribe the blood thinner warfarin more safely and effectively. Researchers will track how often doctors use this genetic guidance and whether it leads to better h…

This study tests whether giving doctors a patient's genetic information before surgery helps them choose safer medications. About 1,900 adults having planned surgery at the University of Chicago will provide a blood sample for genetic testing. Half the time, doctors will see the …

This study compares two support programs for Black men who have been in jail or prison and are at risk for or living with HIV. One group gets health navigation only; the other also gets employment help and up to $340 in incentives. Researchers want to see which approach better co…

This study tests whether a two-day employment program can help young Black men who have sex with men stay engaged in HIV care. Researchers will ask 132 participants about their satisfaction and track changes in job-seeking confidence and sexual health visits over 13 months. The g…

This study looks at whether people with ulcerative colitis (UC) who are in deep remission (no signs of inflammation) can safely reduce or stop their medication. Researchers will compare two groups: those who continue their current therapy and those who decrease or stop it. The go…

This study is testing whether giving expecting parents sleep information and advice can help their babies sleep longer and have fewer sleep problems. About 391 families will be followed for 24 months, with some receiving regular sleep tips and others none. The goal is to see if s…

This study collects DNA from 1200 patients receiving routine care at the University of Chicago. Researchers look for genetic differences that might affect how well a drug works or how likely it is to cause side effects. The goal is to see if giving this genetic information to doc…

This study looks at how heart function relates to recovery in people with severe traumatic brain injury or brain bleeding. Researchers will collect data from routine monitoring and follow up with 50 adults 6 months after hospital discharge. The goal is to better understand the co…

This study looks at whether a blood test can detect HPV DNA in people with HPV-related anal or cervical cancer who are receiving radiation therapy. Researchers will collect blood samples before, during, and after treatment to see if the virus's genetic material shows up and if it…

This study tests whether a Personalized Therapeutics Clinic (PTC) can lower the risk of harmful drug interactions in cancer patients. Participants get genetic testing to see how their medications interact with each other and with their genes. The goal is to help doctors prescribe…

This study aims to understand how changes in gut bacteria (dysbiosis) affect the immune system and gut health in people with long COVID. Researchers will collect stool and blood samples from 400 adults—half with long COVID symptoms and half without. The goal is to find links betw…

This study trains community health workers to create and share personal stories and infographics on social media to promote flu, COVID-19, and other respiratory virus vaccines. Researchers will survey the health workers' social media followers to see if the messages change their …

This study looks at stool samples from 100 critically ill patients to understand how a common bacteria, Pseudomonas aeruginosa, becomes dangerous in the gut. Researchers will test if the gut environment makes the bacteria more harmful. No treatment is given; the goal is to learn …

This study creates a database to track men with prostate cancer who choose prostate ablation—a minimally invasive procedure to destroy cancer cells. Researchers will collect information from medical records on cancer control, side effects, and quality of life for up to 3,000 part…

This study tests whether a tongue-stimulating device (hypoglossal nerve stimulation) for obstructive sleep apnea can improve how the body handles blood sugar and lower heart risks. About 30 overweight or obese adults who cannot use a CPAP machine will wear a continuous glucose mo…

This study looks at how sleep apnea (pauses in breathing during sleep) affects blood sugar levels in adults with type 1 diabetes. Researchers will track blood sugar patterns using continuous glucose monitors in 40 participants. The goal is to understand the link between sleep apn…

This study looks at whether a special MRI scan that measures muscle health and frailty can predict death or the need for a liver transplant in people with liver disease. Researchers will follow 1,200 patients who are already getting an MRI for routine care. The goal is to see if …

This study collects lung tissue from patients awaiting a lung transplant to learn more about pulmonary fibrosis at the cellular level. Researchers will examine cells and proteins linked to the disease. About 90 participants will provide tissue samples, but no experimental treatme…

This study looks at how two natural compounds in food—oxalate and citrate—affect the chance of forming kidney stones. Researchers will measure changes in urine after participants consume sodium oxalate. The goal is to better understand why some people develop stones while others …

This study compares two common methods (a snare device and rigid forceps) for removing IVC filters, which are small devices placed in a vein to catch blood clots. Researchers want to see which method is more successful and faster. About 100 adults with a history of DVT who need t…

This study compares two ways of delivering precise radiation to brain tumors that have spread from other cancers. One group gets the standard extra 2-millimeter safety margin around the tumor, while the other group gets no extra margin. The goal is to see if skipping the margin l…

This study looks at how often infections occur in broken bones near hip or knee replacements. Researchers will test tissue samples from 200 adults having surgery to see how many show signs of infection. The goal is to create better guidelines for diagnosing and treating these com…

This study is building a biobank of blood and tissue samples from 500 patients undergoing cardiac surgery. Researchers will analyze these samples to better understand the causes and progression of heart disease. The goal is to improve future diagnosis and treatment, but no new th…

This study is testing whether a smart knee implant that tracks movement like steps and walking speed can help people recover better after knee replacement surgery. Researchers will also see if the device can reduce the number of follow-up clinic visits. About 150 adults having kn…

This study looks at how two natural compounds in food, oxalate and citrate, interact in the body and affect kidney stone formation. Researchers will measure changes in urine levels of these compounds after participants consume potassium citrate. The study includes 24 adults, some…

This study looks at how working a 24-hour shift affects the immune system of surgery residents. Researchers will measure changes in immune cells and inflammation before and after the shift. The goal is to understand the health risks of sleep deprivation in medical professionals.

This study tests a 12-week program that provides education, navigation, and self-management support to African American adults hospitalized with advanced chronic kidney disease. The goal is to see if the program improves patients' understanding of kidney disease, blood pressure, …

This study tests a new system to help doctors better screen for and manage PTSD in primary care clinics on Chicago's South Side. About 17,000 adults will take part. The goal is to see if this approach leads to more people being diagnosed and getting the right treatment.

This study aims to better understand how well fat grafting works for breast or chest wall reconstruction. Researchers will use 3D photos, MRI, and ultrasound to measure changes in the breast area over time. Participants will also fill out a questionnaire about their satisfaction …

This study tests a computer tool that predicts when the brain is about to swell or run low on oxygen in people with severe traumatic brain injury. About 120 adults in the ICU will be monitored, and the tool's predictions will be checked for accuracy. The goal is to give doctors a…

This observational study at the University of Chicago looks at how kidney stones are linked to insulin resistance and inflammation. Researchers will measure belly fat, blood markers, and urine in 40 people—half with calcium kidney stones and half without. The goal is to understan…

This study compares two types of metal rods used to fix broken shin bones (tibia fractures). One rod allows tiny movements at the fracture site, while the other is standard. Researchers want to see which rod helps bones heal better and causes fewer problems. About 372 adults with…

This study looks at how the drug oxytocin works in women having a C-section. Oxytocin is used to help the uterus contract and prevent heavy bleeding after delivery, but it doesn't always work. Researchers will measure oxytocin levels in the blood and compare them to how well the …

This study looks at whether elderly men (70+) with prostate cancer who have been on hormone therapy for over 3 years can safely stop it. Researchers will check if their testosterone stays at castrate levels without ongoing treatment. The goal is to see if stopping is feasible and…

This study collects and stores tissue and blood samples from people with stomach, esophageal, pancreatic, liver, and other gastrointestinal cancers. The goal is to build a large database of samples and medical information to help researchers understand these cancers better. Parti…

This study is testing whether adding blood and urine biomarkers to a computer risk score can better predict which hospitalized patients will develop severe acute kidney injury (AKI). Researchers will enroll 800 adults at high risk (top 10% by the risk score) and track them for th…

This study aims to find the genes that cause inherited heart and muscle diseases like cardiomyopathy, arrhythmias, and muscular dystrophy. Researchers will collect blood samples from up to 2,000 patients and their families to look for genetic mutations. The goal is to better unde…