Which anesthesia gets you home faster after knee surgery?

NCT ID NCT07672301

Recruiting now Knowledge-focused Sponsor: University of Chicago Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares general anesthesia (given through an IV) with spinal anesthesia (a numbing shot in the back) for people having a knee replacement. The goal is to see which approach allows more patients to go home the same day. Researchers will also track recovery, pain, nausea, and thinking skills after surgery. About 150 adults are being enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: propofol, dexmedetomidine, fentanyl, hydromorphone, mepivacaine
What this could lead to: If it works, this could help doctors choose the best anesthesia for faster recovery and same-day discharge after knee replacement.
What could go wrong: This is an early-phase study with only 150 participants, so results may not apply to everyone. The main goal is comparing discharge rates, not curing disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for TOTAL KNEE ARTHROPLASTY (TKA) are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Emergence Delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TOTAL KNEE ARTHROPLASTY (TKA)

Contacts and locations

Locations

University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.