Timing is everything: new study tests when to give painkiller for safer knee surgery in seniors

NCT ID NCT07271849

Recruiting now Symptom relief Sponsor: Qianfoshan Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether giving the painkiller nalbuphine at different times during knee replacement surgery can better control pain and keep the heart stable in patients aged 65 and older. About 162 participants will receive nalbuphine either during anesthesia or after cement placement. The goal is to find the best timing to improve recovery and reduce complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nalbuphine
What this could lead to: If successful, this could help doctors choose the best time to give nalbuphine during knee replacement to reduce pain and keep the heart stable in older patients.
What could go wrong: This is a small, single-center Phase 4 trial. Results may not apply to all patients, and nalbuphine may not prove better than standard timing for pain or heart stability.

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Conditions

The condition(s) this trial relates to.

osteoarthritis Pain, Postoperative rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMODYNAMICS POSTOPERATIVE PAIN, ACUTE TOTAL KNEE ARTHROPLASTY (TKA)

Contacts and locations

Locations

Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University,
RECRUITING

Jinan, Shandong, 250000, China

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