Can discarded bone reveal the secrets to stronger bones?

NCT ID NCT05732870

Recruiting now Knowledge-focused Sponsor: Relation Therapeutics Source: ClinicalTrials.gov ↗

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This study aims to understand why bones weaken with age, leading to conditions like osteoporosis and osteoarthritis. Researchers will collect bone waste and blood samples from 2,000 people undergoing orthopedic surgery, including those with and without bone disease. By analyzing the cells and genetics in these samples, they hope to identify new targets for future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Relevant orthopaedic surgery (collection of discarded bone waste and blood for analysis)
What this could lead to: If successful, this could identify new drug targets for preventing or treating bone diseases like osteoporosis and osteoarthritis.
What could go wrong: This is an observational study, not a treatment trial. It will take years to analyze data, and findings may not lead to new therapies.

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Conditions

The condition(s) this trial relates to.

bone disorder bone fracture bone marrow disorder osteoarthritis osteoporosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BONE DISEASES BONE FRACTURE BONE MARROW DISEASE OSTEOARTHRITIS OSTEOPOROSIS

Contacts and locations

Locations

Barts Health NHS Trust
RECRUITING

London, United Kingdom
Chase Farm Hospital
RECRUITING

London, United Kingdom
Fitzrovia Hospital/QASMC
RECRUITING

London, United Kingdom
Harley Street Specialist Hospital
ACTIVE_NOT_RECRUITING

London, Greater London, W1G 8HU, United Kingdom
King's College Hospital
NOT_YET_RECRUITING

London, United Kingdom
Luton & Dunstable University Hospital
ACTIVE_NOT_RECRUITING

London, United Kingdom
Royal National Orthopaedic Hospital NHS Trust
NOT_YET_RECRUITING

London, United Kingdom
West Middlesex University Hospital
RECRUITING

London, United Kingdom

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