OSTEOPOROSIS

This study tests whether Denosumab, a drug used for osteoporosis, can help preserve muscle strength and mobility in frail older adults. Researchers will measure changes in leg strength over time. The study involves 155 people aged 65 and older who live in nursing homes or assiste…

This study tests whether a step-down approach—using half-dose denosumab (Prolia) combined with zoledronic acid (Aclasta)—can better prevent bone loss in people who have been on denosumab for at least three years. The trial includes 44 postmenopausal women and men aged 50–85 with …

This study tests two different ways of giving osteoporosis drugs to postmenopausal women with very low bone density. One group gets a repeating 6-month cycle of two drugs for 2 years, while the other gets one drug for a year followed by another for a year. The goal is to see whic…

This study tests whether a single dose of either zoledronic acid or denosumab can prevent bone loss in older adults who have been in the intensive care unit (ICU). It includes 450 women aged 50+ and men aged 70+ who were in the ICU for more than 24 hours. Participants receive one…

This study tests a program called OPTIONS that helps older adults recover after breaking a hip or leg. The program provides exercise, healthy diet advice, and bone-strengthening medication in nursing homes and after patients go home. Researchers will include about 1,500 people ag…

This study compares two FDA-approved medication regimens to treat postmenopausal osteoporosis in women aged 45 and older who are at high risk of fractures. The goal is to see which combination better improves bone density in the spine over 12 months. Participants must not have us…

This study tests whether a special food containing probiotics and prebiotics can help manage bone loss in women aged 60 and older. Over 18 months, researchers will measure bone density and strength in 220 participants. The goal is to see if this dietary approach can slow or impro…

This study tests whether combining two osteoporosis drugs (romosozumab and denosumab) works better than either drug alone for postmenopausal women with weak bones. 90 women will receive one of three treatments for 6 months, and researchers will measure changes in bone density and…

This study tests whether denosumab, a drug used for osteoporosis, can also improve muscle strength and insulin sensitivity in postmenopausal women with type 2 diabetes. About 40 women will receive either denosumab or a placebo for 12 months. The goal is to see if the drug offers …

This study looks at whether drinking dairy milk, pea milk, or almond milk after resistance exercise (3 times a week for a year) helps improve bone strength in postmenopausal women and men aged 50 and older. The goal is to find which drink best supports bone health and reduces ost…

This study looks at whether donepezil, a drug used for Alzheimer's, can improve bone health and lower fracture risk in older adults with mild to moderate Alzheimer's. About 45 participants will take either donepezil or memantine daily for 12 months. Researchers will measure bone …

This study tests whether a tailored exercise program, combined with health screenings, can reduce falls, fractures, and heart problems in people aged 65+ with type 1 or type 2 diabetes. 490 participants will be assigned to either the exercise program or usual care and followed fo…

This study looks at whether a surgeon-initiated referral to a bone health specialist can reduce implant problems and fractures in people with osteoporosis who have hip or knee replacement surgery. About 2,000 participants aged 50 and older with confirmed osteoporosis will be foll…

This study enrolls 200 adults aged 50 and older in a rural area who have had a hip or spine fracture or are on osteoporosis medication. It provides education, monitoring, and follow-up every 4 months for 2 years to help patients stick with their treatment and reduce fracture risk…

This study aims to create an artificial intelligence (AI) system that can automatically diagnose and stage osteoporosis and osteoarthritis from medical images like X-rays and MRIs. Researchers will enroll 2,000 adults to test if the AI can provide more consistent and accurate res…

This study tests whether a patient navigator—a personal health coach—can help older adults prevent another broken bone after a fragility fracture. About 2,634 people aged 50 and older who recently broke a bone will be assigned to either get this extra support or just standard edu…

This study tests a procedure called LOEP that strengthens the hip bone to prevent a second fracture in women over 65 who have already broken one hip. About 2400 women will be randomly assigned to receive the procedure or standard care, and they will be followed for at least 5 yea…

This study tests whether a virtual chiropractor program is practical for people over 50 who have had a spine fracture from osteoporosis. Participants will receive 12 online sessions over 8 weeks covering pain relief, safe movement, exercise, and nutrition. The goal is to see if p…

This study tests a smart wearable device called gaitQ that uses cues to help people with long-term movement conditions like Parkinson's disease, stroke, multiple sclerosis, and arthritis walk better. Researchers will measure walking improvements in 150 participants, including hea…

This study tests a combined program of Baduanjin (a gentle mind-body exercise) and resistance training for elderly patients with both osteoporosis and a herniated disc in the lower back. The goal is to reduce pain, improve muscle strength, and boost quality of life. Researchers w…

This study surveys adults aged 65 and older (women) or 70 and older (men) to measure their understanding of osteoporosis and their general health literacy. Researchers aim to find out what factors influence awareness and knowledge about this bone-weakening disease. No treatments …

This study looks at whether generative AI can help doctors better diagnose complications of rheumatoid arthritis (RA), such as lung disease or heart problems. Researchers will use AI to analyze patient records and suggest possible complications, then see if doctors find these sug…

This study aims to understand how GLP-1 based weight loss medications change muscle and bone in people with obesity. Researchers will compare a group that also follows a diet and exercise program to a group that only gets standard exercise and diet advice. The results will help d…

This study looks at how often men over 50 have spine fractures that were not found before. Researchers will use a special AI program to check CT scans of the chest and belly that were done for other reasons. The goal is to see if AI can help find these hidden fractures, which are…

This study is creating a biobank of blood and tissue samples from 2,000 people with rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, or osteoporosis. Researchers will analyze these samples to find biological markers that can predict how well a patient will respond to…

This study interviews 15 doctors in Alsace, France, who treat frail elderly patients with osteoporosis. The goal is to understand what makes them use (or not use) a practical guide on managing the condition. The findings could help improve how osteoporosis care is delivered to ol…

This study collects bone marrow samples from 24 adults aged 65 and older during hip surgery. Researchers will analyze the cells' metabolism and look for specific genetic changes linked to clonal hematopoiesis (CHIP). The goal is to understand how these changes affect stem cell fu…

This study looks at how brain connections might be different in women with osteoporosis. Researchers will compare brain scans and health surveys from 66 postmenopausal women—some with osteoporosis and fractures, some without fractures, and some healthy. The goal is to understand …

This study is testing a portable ultrasound device that uses sound waves to measure bone density in the lower leg, without any radiation. Researchers will compare its results to standard DXA X-ray scans in 350 healthy men and women aged 21 to 55. The goal is to see if the new dev…

This study aims to validate and check the reproducibility of laboratory tests, equipment, and techniques used in research on chronic diseases like obesity, diabetes, and heart disease. Researchers will compare old and new testing methods to ensure results are accurate and consist…

This study is testing a robotic system called Epione to help doctors place needles or instruments into the pelvis and spine during image-guided procedures. The goal is to see if the robot makes these procedures more feasible, safe, and accurate compared to the standard freehand m…

This study aims to see if a self-administered questionnaire can accurately capture family history and signs of rare genetic bone diseases in adults with osteoporosis. Researchers will compare the questionnaire results with detailed family trees (pedigrees) from 58 participants. T…

This study is testing whether a new scoring system helps doctors choose the best treatment for people with spine fractures caused by osteoporosis. About 648 adults over 50 will be followed for 3 months to see if following the score's advice leads to faster return to normal mobili…

This study looks at whether blood tests called Bone Turnover Markers (BTMs) can quickly show if osteoporosis medication is working in postmenopausal women. Currently, doctors use DEXA scans to check bone density, but these change slowly. BTMs might show results in just 3 to 6 mon…

This study looks at whether online education works as well as in-person classes for people over 50 with osteoporosis. About 600 participants will either get standard information, attend three group sessions with a physiotherapist, or use a year-long online program. Researchers wi…

This study aims to better understand how bones break in people with osteoporosis, a condition that makes bones weak. Researchers will use CT scans and computer models to study bone samples from 52 adults having hip replacement surgery. The goal is to find new ways to predict frac…

This study tests a new, safe ultrasound technology called REMS to measure bone density in children aged 5 to 18 who have conditions that weaken bones, like brittle bone disease or osteoporosis. Unlike standard X-ray methods, REMS uses no radiation. The goal is to see how well REM…

This study looks at whether blocking a protein called RANKL—already used to treat bone loss—can improve egg health and fertility in women. Researchers will test this in mice, monkeys, and human ovary tissue. The goal is to find new ways to help women with infertility, especially …

This study looks at bone density in 100 pregnant women (ages 30-45) between weeks 35 and 41 of pregnancy. Half are carrying one baby, half are carrying twins. Researchers use a special ultrasound-like scan (REMS) and questionnaires to see if twin pregnancies cause greater bone lo…