OSTEOPOROSIS

This study tests whether denosumab, a drug used for osteoporosis, can also improve muscle strength and insulin sensitivity in postmenopausal women with type 2 diabetes. About 40 women will receive either denosumab or a placebo for 12 months. The goal is to see if the drug offers …

This study looks at whether drinking dairy milk, pea milk, or almond milk after resistance exercise (3 times a week for a year) helps improve bone strength in postmenopausal women and men aged 50 and older. The goal is to find which drink best supports bone health and reduces ost…

This study tests whether a special food containing probiotics and prebiotics can help manage bone loss in women aged 60 and older. Over 18 months, researchers will measure bone density and strength in 220 participants. The goal is to see if this dietary approach can slow or impro…

This study tests whether combining two osteoporosis drugs (romosozumab and denosumab) works better than either drug alone for postmenopausal women with weak bones. 90 women will receive one of three treatments for 6 months, and researchers will measure changes in bone density and…

This study tests whether a step-down approach—using a half-dose of the osteoporosis drug denosumab along with another medication called zoledronic acid—can better prevent bone loss when stopping long-term denosumab treatment. It includes 44 postmenopausal women and men aged 50–85…

This study looks at whether donepezil, a drug used for Alzheimer's, can improve bone health and lower fracture risk in older adults with mild to moderate Alzheimer's. About 45 participants will take either donepezil or memantine daily for 12 months. Researchers will measure bone …

This study tests whether a single dose of either zoledronic acid or denosumab can prevent bone loss in older adults who have been in the intensive care unit (ICU). It includes 450 women aged 50+ and men aged 70+ who spent at least 2 days in the ICU. Participants receive one of th…

This study tests whether a tailored exercise program, combined with health screenings, can reduce falls, fractures, and heart problems in people aged 65+ with type 1 or type 2 diabetes. 490 participants will be assigned to either the exercise program or usual care and followed fo…

This study compares two FDA-approved medication combinations to treat postmenopausal osteoporosis in women aged 45 and older who have a high risk of fractures. The goal is to see which regimen better improves bone density in the lower spine over 12 months. Participants must not h…

This study tests two different ways of giving osteoporosis drugs to postmenopausal women with very low bone density. One group gets a 2-year cycle of romosozumab and denosumab, while the other gets 1 year of romosozumab followed by 1 year of denosumab. The goal is to see which sc…

This study looks at whether a surgeon-initiated referral to a bone health specialist can reduce implant problems and fractures in people with osteoporosis who have hip or knee replacement surgery. About 2,000 participants aged 50 and older with confirmed osteoporosis will be foll…

This study enrolls 200 adults aged 50 and older in a rural area who have had a hip or spine fracture or are on osteoporosis medication. It provides education, monitoring, and follow-up every 4 months for 2 years to help patients stick with their treatment and reduce fracture risk…

This study tests a program called OPTIONS that helps older adults recover after breaking a hip or leg. The program provides exercise, healthy diet advice, and bone-strengthening medication in nursing homes and after patients go home. Researchers will include about 1,500 people ag…

This study tests whether Denosumab, a drug already used for osteoporosis, can also preserve or improve muscle health in frail adults aged 65 and older. Researchers will measure changes in leg strength and mobility in 155 participants living in nursing homes or assisted living. Th…

This study is testing an artificial intelligence (AI) system that can automatically diagnose and stage osteoporosis and osteoarthritis from medical images like X-rays and MRIs. The goal is to make diagnosis more consistent and catch problems earlier. Researchers at Peking Univers…

This study tests a procedure called LOEP that strengthens the hip bone to prevent a second fracture in women over 65 with osteoporosis who have already broken one hip. About 2,400 women will either receive the procedure or standard care and be followed for at least 5 years. The g…

This study tests whether a patient navigator—someone who guides patients to bone health specialists—can reduce the risk of another fracture in adults aged 50 and older who have already had a fragility fracture (like a broken hip or wrist). About 2,634 participants will be assigne…

This study tests whether combining Baduanjin (a gentle mind-body exercise) with resistance training can reduce pain, improve muscle strength, and boost quality of life in older adults with both osteoporosis and lumbar disc herniation. About 110 Chinese patients will participate d…

This study tests a smart wearable device called gaitQ that uses cues to help people with long-term movement conditions like Parkinson's, stroke, multiple sclerosis, arthritis, and osteoporosis walk better. Researchers will measure improvements in walking speed, step length, and f…

This study tests whether a virtual chiropractor-led program is practical for people over 50 who have had a spine fracture due to osteoporosis. Participants will receive 12 online sessions over 8 weeks covering pain relief, safe movement, exercise, and nutrition. The goal is to se…

This study looks at whether blood tests called Bone Turnover Markers (BTMs) can quickly show if osteoporosis medication is working in postmenopausal women. Currently, doctors use DEXA scans to check bone density, but these change slowly. BTMs might show results in just 3 to 6 mon…

This study looks at whether online education works as well as in-person classes for people over 50 with osteoporosis. About 600 participants will either get standard information, attend three group sessions with a physiotherapist, or use a year-long online program. Researchers wi…

This study is testing whether a new scoring system helps doctors choose the best treatment for people with spine fractures caused by osteoporosis. About 648 adults over 50 will be followed for 3 months to see if following the score's advice leads to faster return to normal mobili…

This study looks at how GLP-1 weight loss medications change muscle and bone in people with obesity. About 50 adults aged 18-50 with a BMI of 30-40 will take the drug and either follow a diet and exercise program or just standard care. Researchers will measure muscle mass, bone h…

This study aims to better understand how bones break in people with osteoporosis, a condition that makes bones weak. Researchers will use CT scans and computer models to study bone samples from 52 adults having hip replacement surgery. The goal is to find new ways to predict frac…

This study interviews 15 doctors in Alsace who treat frail elderly patients with osteoporosis. The goal is to find out what makes them use (or not use) a practical guide on managing the condition. The results could help improve care and reduce fractures in older adults.

This study is testing a new portable ultrasound device that uses sound waves to measure bone density in the lower leg, without radiation. Researchers will compare its results to standard DXA X-ray scans in 350 healthy men and women aged 21 to 55. The goal is to see if the ultraso…

This study tests a new, safe ultrasound technology called REMS to measure bone density in children aged 5 to 18 who have conditions that weaken bones, like brittle bone disease or osteoporosis. Unlike standard X-ray methods, REMS uses no radiation. The goal is to see how well REM…

This study looks at bone marrow from people aged 65 and older who are having hip surgery. Researchers will check for common aging-related mutations in blood stem cells and study how those mutations change the cells' metabolism. The goal is to understand why some people develop cl…

This study surveys 190 adults aged 65+ (women) or 70+ (men) to measure their health literacy and awareness of osteoporosis. Researchers aim to identify factors that influence knowledge about this bone-weakening disease, which can lead to fractures. The goal is to improve screenin…

This study looks at whether blocking a protein called RANKL—already used to treat bone loss—can improve egg health and fertility in women. Researchers will test this in mice, monkeys, and human ovary tissue. The goal is to find new ways to help women with infertility, especially …

This study aims to verify that laboratory tests, equipment, and procedures used in research on conditions like obesity, diabetes, heart disease, and bone loss are accurate and give consistent results. About 100 healthy volunteers and people with these conditions will take part. T…

This study looks at bone density in 100 pregnant women (ages 30-45) between weeks 35 and 41 of pregnancy. Half are carrying one baby, half are carrying twins. Researchers use a special ultrasound-like scan (REMS) and questionnaires to see if twin pregnancies cause greater bone lo…

This study tests whether generative AI can help doctors better diagnose complications of rheumatoid arthritis (RA), such as lung or heart problems. Researchers will use AI to analyze patient records and suggest possible hidden conditions. Doctors will then decide if the AI's sugg…

This study is creating a biobank—a collection of blood samples and health data—from 2,000 people with rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, or osteoporosis. Researchers want to find biological markers that can predict how well a person will respond to trea…

This study looks at how often spine fractures happen in men over 50 who get a chest or belly CT scan for reasons not related to bone health. Researchers will use AI software to check the scans for fractures that might otherwise be missed. The goal is to learn more about how commo…