OSTEOPOROSIS

This study tests a device called Vessel-X® that uses a special container to deliver bone cement into fractured vertebrae caused by osteoporosis. The goal is to reduce cement leakage and improve safety compared to standard procedures. About 146 adults aged 40 to 95 with spinal fra…

This study compares two treatment schedules for postmenopausal women with severe osteoporosis. One group gets romosozumab for 12 months then denosumab for 12 months. The other group cycles between the two drugs every 6 months for 2 years. Researchers will measure bone density and…

This Phase 2 study tests whether a Traditional Chinese Medicine (TCM) herbal formula can improve muscle strength and bone health in pre-frail adults aged 65 and older, compared to the nutritional supplement HMB. Over 24 weeks, 90 participants will take either the TCM powder or HM…

This study tests a new drug called SAL056 in postmenopausal women with osteoporosis. The goal is to find the safest and most effective dose. About 200 women aged 45 to 80 will receive different doses of the drug or a control treatment for around 10 weeks. The study focuses on sid…

This study tests whether a special exercise program that combines rhythm and multitasking (called RYMA) can reduce falls, fractures, and heart problems in people aged 65 and older with type 1 or type 2 diabetes. Participants will be screened for fall risk, bone health, nerve func…

This study aims to see how well two different FDA-approved medication regimens improve bone density in postmenopausal women with osteoporosis who are at high risk of fractures. About 50 women aged 45 and older will receive one of the two treatments for 12 months. The main goal is…

This study tests a special medical food containing probiotics and prebiotics to see if it can help slow or reverse bone loss in older women. Researchers will measure changes in bone density and strength over 18 months. The goal is to find a safe, dietary approach to manage osteop…

This study tests whether a single dose of either zoledronic acid or denosumab can prevent bone loss in older adults who have been in the intensive care unit (ICU). The trial will include 450 women aged 50+ and men aged 70+ who spent at least 2 days in the ICU. Participants will r…

This study compares drinking dairy milk, pea-based, or almond-based beverages after resistance training sessions for 12 months. It includes 150 postmenopausal women and men aged 50 and older. The goal is to see which drink best improves bone density and strength, helping prevent …

This study tests whether a dietary fiber supplement (soluble corn fiber) can help older men absorb more calcium and improve bone health. Thirty male veterans aged 60 and older will take the fiber supplement and then have their calcium absorption measured. The goal is to see if ch…

This study tests whether Denosumab, a drug used for osteoporosis, can help preserve muscle strength and mobility in frail adults aged 65 and older living in nursing homes or assisted living. Participants will receive either Denosumab or Zoledronic Acid, and researchers will measu…

This study tests a program called OPTIONS that helps older adults recover after breaking a hip or leg. The program provides information on exercise, healthy eating, and bone-strengthening medications to patients in nursing homes and after they go home. Researchers will include ab…

This study looks at two surgical methods to fix the spine in people with osteoporosis (weak bones). It compares screws that are reinforced with bone cement to regular hollow screws. The goal is to see which method provides better stability, pain relief, and recovery, with fewer c…

This study is testing a fracture liaison service (FLS) combined with medication management for people with osteoporosis in a rural area. The program provides education, monitoring, and follow-up to help patients take their medications as prescribed. Researchers will enroll 200 ad…

This study tests whether denosumab, a drug used for osteoporosis, can also improve muscle mass, strength, and insulin sensitivity in postmenopausal women with type 2 diabetes. About 40 women will receive either denosumab or a placebo for 12 months. The goal is to see if the drug …

This study tests whether a gradual reduction of denosumab (Prolia) combined with zoledronic acid (Aclasta) can prevent bone loss after long-term osteoporosis treatment. 44 postmenopausal women and men over 50 who have taken denosumab for at least 3 years will be randomly assigned…

This study tests whether combining two osteoporosis drugs (romosozumab and denosumab) works better than either drug alone for postmenopausal women with weak bones. About 90 women will receive one of three treatments for 6 months. The goal is to see which approach improves bone de…

This study tests whether an AI system (VeriOsteo OP) can help doctors find osteoporosis earlier in adults aged 40 to 80 who are at high risk. About 1,180 participants will be randomly assigned to get either AI-guided screening or usual care. The goal is to see if AI leads to bett…

This study is testing a new blood-based method to diagnose osteoporosis and predict fracture risk. Researchers will analyze the vitality and behavior of certain blood cells from 120 healthy, osteopenic, and osteoporotic adults aged 40 and older. The goal is to see if this approac…

This study checks if a computer tool called BBCT-hip can accurately predict the risk of breaking the thigh bone (femur) when a person falls. Researchers will enroll 300 postmenopausal women with osteoporosis—150 who have already had a fracture and 150 who have not. All will get a…

This study will test whether an AI program can find vertebral fractures (broken spine bones) that might be missed on CT scans done for other reasons. Researchers will look at scans from 250 men aged 50 or older to see how common these fractures are. The goal is to improve detecti…

This study is testing an artificial intelligence system that reads medical images like X-rays and MRIs to diagnose and stage osteoporosis and osteoarthritis. Researchers aim to make diagnosis more accurate and consistent. The trial will enroll 2,000 adults who have already had im…

This study tests whether a generative AI tool can help doctors diagnose complications and co-existing diseases in people with rheumatoid arthritis. The AI reviews patient records and suggests possible issues like lung or heart problems. Doctors then decide if the AI's suggestions…

This study is testing a portable ultrasound device called POROUS R4C that measures bone in the lower leg without radiation. Researchers want to see if it can estimate bone mineral density as accurately as the standard X-ray method (DXA). The study will include 350 healthy men and…

This study tests a procedure called LOEP that strengthens the hip bone to prevent a second fracture in women over 65 with osteoporosis who have already broken one hip. About 2400 women will either receive the procedure or standard care and be followed for at least 5 years. The go…

This study tests whether a patient navigator—someone who contacts you after a fracture and connects you to a bone health specialist—can help older adults avoid future fractures. Over 2,600 people aged 50 and older who recently had a fragility fracture will be assigned to either t…

This study tests a walking program called Walk-BEST for people aged 70+ with osteoporosis. The program uses a sensor to improve walking and aims to reduce falls and fractures. Researchers want to see if it's practical and acceptable for 28 participants.

This study tests whether a virtual chiropractor program is practical for people over 50 who have had a spine fracture from osteoporosis. Participants will receive 12 online sessions over 8 weeks covering pain management, safe movement, exercise, and nutrition. The goal is to see …

This study tests a gentle exercise program combining Baduanjin (a traditional Chinese mind-body practice) with resistance training for older adults with osteoporosis and a slipped disc in the lower back. Researchers want to see if it can reduce pain, improve muscle strength, and …

This study investigates whether a protein called lumican, found in the blood, can identify postmenopausal women who have fragile bones but normal bone density scans. About 100 women will have their bone density, muscle strength, and blood lumican levels measured. The goal is to s…

This study looks at a new tool called the Functional Muscle-Bone Incongruity Index (FKUI) that combines handgrip strength and bone density measurements. Researchers want to see if this combined approach gives a fuller picture of muscle and bone health than looking at each measure…

This study looks at whether a standard shoulder X-ray can detect bone loss in the weak arm of people who have had a stroke. Researchers will measure bone thickness on X-rays from 65 stroke survivors and compare those measurements to the gold-standard DXA bone density scan. If the…

This study is testing a robotic system called Epione to help doctors place needles or instruments into the bones of the pelvis and spine. The goal is to see if the robot makes these procedures more feasible, safe, and accurate compared to doing them by hand. Sixty adults who are …

This study aims to find small molecules called microRNAs in the blood that can predict how well two osteoporosis drugs (romosozumab and abaloparatide) work in postmenopausal women. Researchers will measure bone density and blood markers over 12 months in 42 women. The goal is to …

This study is looking at what happens to muscle and bone when people lose weight using the drug tirzepatide. Researchers want to see if adding protein shakes and resistance exercise can protect muscle and bone. The study will enroll 50 adults with obesity and track changes over 6…

This study looks at how endurance exercise (like walking or cycling) and resistance exercise (like lifting weights) affect bone health in older veterans aged 60 and over. Researchers want to see if either type of exercise causes bone breakdown and how the body adapts over time. T…

This study looks at how different brain regions communicate in women with and without osteoporosis. Researchers will use MRI scans and blood tests to compare brain connectivity and bone markers in 60 postmenopausal women. The goal is to better understand the link between the brai…

This study looks at whether a new scoring system (called the OF score) helps doctors choose the best treatment for people with spine fractures due to osteoporosis. About 648 adults over 50 will be observed to see if following the score's advice leads to faster return to normal mo…

This study is not testing a new drug or treatment. Instead, researchers want to make sure their lab tests and equipment give accurate and repeatable results when studying conditions like obesity, diabetes, heart disease, and bone loss. Up to 100 healthy volunteers and people with…

Researchers are testing a 14-question survey to see if it can help detect rare genetic bone diseases (like osteogenesis imperfecta) in adults with osteoporosis. The study will enroll 58 participants who will fill out the online questionnaire. The goal is to see if the questionnai…

This study investigates whether blocking a protein called RANKL can help eggs mature and improve fertility treatments. Researchers will use denosumab, a drug already approved for osteoporosis, in lab studies with human and mouse eggs. The goal is to understand if RANKL manipulati…

This study looks at bone density in 100 pregnant women (ages 30-45) with either one baby or twins during the third trimester. Researchers use a special ultrasound-like scan and questionnaires to check bone health and fracture risk. The goal is to see if carrying twins leads to gr…

This study collects bone marrow from 24 adults aged 65+ having hip surgery to understand how common aging-related blood cell mutations (called CHIP) change cell metabolism. Researchers will compare gene activity in mutated versus normal stem cells. The goal is to learn more about…

This study tests whether digital education or in-person classes help people over 50 with osteoporosis take better care of themselves. Six hundred participants will be split into three groups: one gets standard information, another attends three group sessions with a physiotherapi…

This study is creating a biobank of blood and tissue samples from 2,000 people with rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, or osteoporosis. Researchers will analyze these samples to find biomarkers that predict how well a patient responds to treatment. The …

This study tests a new, radiation-free ultrasound technology called REMS to measure bone density in children aged 5 to 18 who have conditions that weaken bones, such as brittle bone disease or osteoporosis. The goal is to see if REMS can work as well as the standard X-ray method …

This study looks at how much older adults (women 65+ and men 70+) know about osteoporosis and their overall health literacy. Researchers will use surveys to measure awareness and understanding, aiming to find gaps that could lead to better education and prevention. No treatments …

This study looks at bone samples from 52 adults having hip replacement surgery to understand how osteoporosis causes tiny damage that leads to fractures. Researchers will use CT scans and computer models to compare healthy and osteoporotic bones. The goal is to create better ways…

This study interviews 15 doctors in Alsace, France, who treat elderly patients with osteoporosis and have used a practical guide on the condition. The goal is to find out what helps or prevents them from using the guide in their daily practice. By understanding these factors, res…

This study looks at how the drug romosozumab affects bone-making cells in postmenopausal women with osteoporosis. Researchers will take small bone samples to count these cells early and late in treatment. The goal is to understand why the drug works, not to test a new treatment. …

This study looks at whether blood tests called bone turnover markers can quickly show if osteoporosis drugs are working in postmenopausal women. Forty women will receive either bone-strengthening or bone-building medications for six months. The goal is to see if these blood tests…

This study looks at whether having a surgeon send patients with osteoporosis to a bone specialist after hip or knee replacement leads to fewer implant problems and broken bones. About 2,000 adults over 50 with confirmed osteoporosis will be observed for two years. The goal is to …

This study looks at whether donepezil, a common Alzheimer's medication, can improve bone density and reduce fracture risk in older adults with mild to moderate Alzheimer's. Researchers will compare donepezil to another drug, memantine, over 12 months in 45 participants. The goal …