ICU survivors at risk of brittle bones: new trial tests One-Dose fix

NCT ID NCT04608630

Recruiting now Disease control Sponsor: Australian and New Zealand Intensive Care Research Centre Source: ClinicalTrials.gov ↗

First seen Mar 28, 2026 · Last updated May 01, 2026 · Updated 6 times

Summary

This study tests whether a single dose of either zoledronic acid or denosumab can prevent bone loss in older adults who have been in the intensive care unit (ICU). The trial will include 450 women aged 50+ and men aged 70+ who spent at least 24 hours in the ICU. Participants will receive one of the two bone-strengthening drugs or a placebo, and their bone density will be measured over one year.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Contact

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Locations

Alfred Health
COMPLETED

Melbourne, Victoria, 3004, Australia
Auckland City Hospital
RECRUITING

Auckland, 1023, New Zealand

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Austin Health
COMPLETED

Melbourne, Victoria, 3084, Australia
Barwon Health, University Hospital Geelong
RECRUITING

Geelong, Victoria, 3220, Australia

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Blacktown Hospital
RECRUITING

Sydney, New South Wales, 2148, Australia

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Eastern Health - Box Hill Hospital
RECRUITING

Melbourne, Victoria, 3128, Australia

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Fiona Stanley Hospital
RECRUITING

Perth, Western Australia, 6150, Australia

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Gold Coast University Hospital
RECRUITING

Southport, Queensland, 4215, Australia

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Prince of Wales Hospital
RECRUITING

Sydney, New South Wales, 2031, Australia

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Royal Adelaide Hospital
RECRUITING

Adelaide, South Australia, 5000, Australia

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Royal Melbourne Hospital
RECRUITING

Melbourne, Victoria, 3052, Australia

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Royal Prince Alfred Hospital
RECRUITING

Sydney, New South Wales, Australia

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St John of God Hospital Murdoch
RECRUITING

Perth, Western Australia, 6150, Australia

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St John of God Hospital Subiaco
RECRUITING

Perth, Western Australia, 6008, Australia

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St Vincent's Health Sydney
RECRUITING

Sydney, New South Wales, 2010, Australia

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St Vincents Hospital Melbourne
RECRUITING

Melbourne, Victoria, 3065, Australia

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Sunshine Coast University Hospital
RECRUITING

Birtinya, Queensland, 4575, Australia

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The Wesley Hospital
RECRUITING

Brisbane, Queensland, 4066, Australia

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Wellington Regional Hospital
RECRUITING

Wellington, 6021, New Zealand

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Western Health - Footscray Hospital
RECRUITING

Melbourne, Victoria, 3011, Australia

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Western Health - Sunshine Hospital
RECRUITING

Melbourne, Victoria, 3021, Australia

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Wollongong Hospital, Illawarra Shoalhaven Health
RECRUITING

Wollongong, New South Wales, 2525, Australia

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Conditions

Explore the condition pages connected to this study.

CRITICAL ILLNESS OSTEOPOROSIS