ICU survivors at risk of brittle bones: new trial tests One-Time fix

NCT ID NCT04608630

Recruiting now Disease control Sponsor: Australian and New Zealand Intensive Care Research Centre Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a single dose of either zoledronic acid or denosumab can prevent bone loss in older adults who have been in the intensive care unit (ICU). The trial will include 450 women aged 50+ and men aged 70+ who spent at least 2 days in the ICU. Participants will receive one of the two bone-strengthening drugs or a placebo, and their bone density will be measured over one year.

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Conditions

The condition(s) this trial relates to.

Critical Illness osteoporosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRITICAL ILLNESS OSTEOPOROSIS

Contacts and locations

Locations

Alfred Health
COMPLETED

Melbourne, Victoria, 3004, Australia
Auckland City Hospital
RECRUITING

Auckland, 1023, New Zealand
Austin Health
COMPLETED

Melbourne, Victoria, 3084, Australia
Barwon Health, University Hospital Geelong
RECRUITING

Geelong, Victoria, 3220, Australia
Blacktown Hospital
RECRUITING

Sydney, New South Wales, 2148, Australia
Eastern Health - Box Hill Hospital
RECRUITING

Melbourne, Victoria, 3128, Australia
Fiona Stanley Hospital
RECRUITING

Perth, Western Australia, 6150, Australia
Gold Coast University Hospital
RECRUITING

Southport, Queensland, 4215, Australia
Prince of Wales Hospital
RECRUITING

Sydney, New South Wales, 2031, Australia
Royal Adelaide Hospital
RECRUITING

Adelaide, South Australia, 5000, Australia
Royal Melbourne Hospital
RECRUITING

Melbourne, Victoria, 3052, Australia
Royal Prince Alfred Hospital
RECRUITING

Sydney, New South Wales, Australia
St John of God Hospital Murdoch
RECRUITING

Perth, Western Australia, 6150, Australia
St John of God Hospital Subiaco
RECRUITING

Perth, Western Australia, 6008, Australia
St Vincent's Health Sydney
RECRUITING

Sydney, New South Wales, 2010, Australia
St Vincents Hospital Melbourne
RECRUITING

Melbourne, Victoria, 3065, Australia
Sunshine Coast University Hospital
RECRUITING

Birtinya, Queensland, 4575, Australia
The Wesley Hospital
RECRUITING

Brisbane, Queensland, 4066, Australia
Wellington Regional Hospital
RECRUITING

Wellington, 6021, New Zealand
Western Health - Footscray Hospital
RECRUITING

Melbourne, Victoria, 3011, Australia
Western Health - Sunshine Hospital
RECRUITING

Melbourne, Victoria, 3021, Australia
Wollongong Hospital, Illawarra Shoalhaven Health
RECRUITING

Wollongong, New South Wales, 2525, Australia

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