OSTEOPOROSIS

This study tested whether the drug abaloparatide (Tymlos) can reduce bone loss after total knee replacement in people with osteoporosis or osteopenia. 58 participants took the drug for 18 months. The main goal was to see if bone density around the new knee improved compared to be…

This study tested whether combining a Mediterranean diet with progressive resistance training could improve bone density in adults aged 65 and older. Over 12 months, 22 participants followed the diet and exercise program, while 19 received no structured intervention. Researchers …

This study looked at two osteoporosis medications—romosozumab and denosumab—in 54 people who take long-term steroids and have weak bones. Participants first received either romosozumab for 12 months followed by denosumab, or denosumab alone for 24 months. Then everyone stayed on …

This study looked at 45 people with osteoporosis caused by long-term steroid use. Participants had stopped taking denosumab and were switched to either zoledronic acid or alendronate at different times. The goal was to see which timing and drug best controlled bone loss markers. …

This study tested whether alendronate, a drug used for osteoporosis, can improve bone density in people with HIV. 140 participants received either alendronate or a placebo, along with calcium and vitamin D, for 2 years. The goal was to see if the drug could strengthen bones and r…

This study tested whether denosumab, a drug given as a shot every 6 months, can improve bone density in people with osteoporosis caused by systemic mastocytosis. 24 adults with the condition took part. The goal was to see if the drug strengthens bones and prevents fractures bette…

This study tested whether a daily supplement made from kefir peptides could help heal broken bones faster in postmenopausal women with osteoporosis. Thirty women with upper arm or wrist fractures were randomly assigned to receive either the kefir supplement or standard care alone…

This study tested whether a bone-building drug (teriparatide) and a vibrating platform, alone or together, could improve bone density in 60 adults with chronic spinal cord injury who had low bone mass. Participants received daily injections of teriparatide, used a vibration devic…

This study looked at whether adding eldecalcitol (a vitamin D-like drug) to denosumab (a bone-strengthening shot) works better than denosumab with regular vitamin D for postmenopausal women with weak bones (osteoporosis). About 100 women took part for 12 months. The main goal was…

This study looked at the best way to prevent bone loss after stopping denosumab, a common osteoporosis treatment. Researchers tested giving alendronate first, then zoledronate, versus zoledronate alone in 44 postmenopausal women and men over 50. The goal was to see which approach…

This study tested whether taking a soluble corn fiber supplement for one year could improve bone health in healthy adolescents aged 10-13. 177 teens were randomly assigned to receive either the fiber supplement, fiber plus calcium, a placebo, or placebo plus calcium. Bone density…

This pilot study tested whether a year of monthly romosozumab injections, followed by a year of weekly alendronate pills, can improve bone health in women with chronic spinal cord injury and osteoporosis. Twelve non-ambulatory women participated. The goal was to see if this two-s…

This study tested whether a 12-week program of exercise and a nutritional supplement (containing HMB, protein, vitamin D, and omega-3) could improve muscle strength and mass in people with both osteoporosis and sarcopenia (age-related muscle loss). Thirteen participants were rand…

This study looked at whether moderate aerobic exercise or resistance exercise is better for improving bone density in postmenopausal women with type 2 diabetes and osteoporosis. Fifty women aged 50-60 did either treadmill walking or resistance training three times a week for 12 w…

This phase 3 trial tested whether a biosimilar called Bmab 1000 works as well as the established drug Prolia® for treating osteoporosis in postmenopausal women. 479 women aged 55-79 with osteoporosis received either Bmab 1000 or Prolia® as an injection every 6 months. The study m…

This study tested a portable ultrasound device to measure bone thickness and porosity in 50 adults over 50 years old. The goal was to see if this radiation-free method could help identify people at risk for osteoporotic fractures as accurately as standard X-ray scans. The approac…

This study tested a simple questionnaire to find women at risk for osteoporosis during their hospital stay. Over 3,200 women aged 50-80 answered questions about risk factors, and those at risk were offered a bone density scan. The goal was to catch osteoporosis earlier and connec…

This study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were follo…

This pilot study tested a virtual program designed to help older men at high risk for fractures reduce their risk of falls and broken bones. The program included personalized exercise plans delivered through a smartphone app and virtual nutrition counseling. Researchers enrolled …

This study tested whether a single dose of zoledronic acid, a drug already used for osteoporosis, can prevent the rapid bone loss that often follows a spinal cord injury. Researchers enrolled 60 adults who had recently lost the ability to walk due to injury. They measured changes…

This study tested whether a virtual rehabilitation program called VIVA is feasible for people with spine fractures caused by osteoporosis. The program includes weekly online sessions to help reduce pain and improve movement and quality of life. The study involved 34 participants …

This study tested whether playing balance games on a Wii Fit board could help women aged 40-60 who have osteoporosis after a mastectomy. Sixty women participated, and their balance was measured before and after eight weeks of training. The goal was to see if this fun, home-like e…

This completed pilot study aimed to estimate how common osteoporosis is in France, starting with the Alpes-Maritimes region. Researchers enrolled 800 participants who each received a bone densitometry scan. The study was observational and did not test any treatment.

This study checked whether women over 50 who had severe osteoporotic fractures (like hip or spine breaks) were scheduled for osteoporosis treatment at Nîmes University Hospital. Researchers reviewed hospital records of 500 patients to see if treatment was planned. The goal was to…

This study observed 30 elderly patients (over 65) who had a specific type of neck fracture (odontoid fracture) from a minor fall or low-energy injury. Researchers measured bone density, vitamin D levels, and other bone health markers to understand why these fractures happen. They…

This study looked at 47 people with bullous pemphigoid, a blistering skin condition, who were treated with high-dose topical corticosteroids (clobetasol propionate) for 6 months. Researchers measured bone mineral density at the start, at 3 months, and at 6 months to see if the tr…

This completed study tested a smart wearable device called gaitQ that monitors and cues walking in people with long-term movement conditions like Parkinson's, stroke, multiple sclerosis, and arthritis. Researchers collected movement data from 98 participants in a lab to see if th…

This study looked at how teriparatide (Forsteo), a daily injection, builds new bone in postmenopausal women with osteoporosis. Nineteen women took the drug for two years. The goal was not to test if it works, but to understand exactly how it changes bone density and turnover over…

This study followed 59 nurses during their first year of work to see if night shifts harm bone health. Researchers measured bone density and markers of bone turnover in night shift nurses compared to day shift nurses. The goal was to understand if shift work increases the risk of…

This completed study evaluated existing osteoporosis patient education programs in Danish municipalities. Researchers compared over 3,000 people who took part in group education sessions (covering medication, diet, and exercise) with a matched group who did not. They measured eff…

This study tested whether a special CT scan (DECT) can better predict fracture risk in women with osteoporosis than the usual bone density test (DEXA). Seven women aged 60 or older participated. The goal was to develop a computer tool that analyzes bone structure from the scan to…

This study looked at whether the difference between how long it takes someone to actually perform a 'get up and walk' test versus how long they imagine it takes can predict future falls. Researchers followed 67 osteoporosis patients for a year after the tests. The goal was to see…

This study looked at 70 elderly women, half with osteoporosis and half without, to see if lower body muscle strength is linked to bone density. Researchers measured hip and knee strength using a special machine and compared it to bone scans. The goal was to better understand risk…

This completed study looked at 44 stroke patients to see how their bone density differs between the paralyzed and non-paralyzed leg. Researchers measured bone density in the hip and spine using a special X-ray scan. The goal was to better understand which clinical factors are lin…

This study looked at whether using regular CT scans (already done for other reasons) can better predict the risk of spine fractures in people over 50, compared to the standard FRAX risk score. Researchers analyzed CT images from nearly 2,800 adults taken five years apart. The goa…

This study looked at a process called autophagy, which is how cells clean out damaged parts, in 82 women over 65 with osteoporosis. Some also had Alzheimer's disease. Researchers measured autophagy levels in bone cells from hip samples to see if poor cell cleanup links bone loss …

This study tested whether educational podcasts and videos created by artificial intelligence could improve knowledge about osteoporosis and digital health literacy. Sixty adults aged 45 and older with osteoporosis or at risk for it received either audio or video content based on …

This early-stage study tested several new oral tablet versions of a bone-building hormone (hPTH 1-34) in 45 healthy men aged 18-35. The goal was to see how well the body absorbs these new tablets compared to an existing oral tablet and a standard daily injection. Researchers meas…

This study examined the relationship between metabolic syndrome and vitamin D levels in 549 older adults (65+). Researchers collected health questionnaires and blood samples to understand how these factors are connected. The goal was to gather knowledge, not to test a treatment.

This study tested whether CT scans can better measure bone health and predict fracture risk in 560 smokers with and without COPD. Researchers used CT images of the spine and ankle to assess bone structure, alongside standard bone density tests. The goal is to create a more accura…

This study followed 82 postmenopausal women with rheumatoid arthritis to see how their bone density changed over time. Researchers compared different arthritis medications and osteoporosis treatments to understand which approaches best protect bone health. The goal was to gather …

This study looked at whether working night shifts for just three nights in a row can disrupt bone health. Twenty healthy adults aged 20-40 either followed a normal sleep schedule or stayed awake at night and slept during the day. Researchers measured bone turnover markers to see …

This study aimed to understand how fat cells in bone marrow contribute to bone loss in osteoporosis. Researchers took bone cells from 20 adults undergoing hip replacement surgery and exposed them to secretions from fat cells in the lab. By measuring changes in gene activity, they…

This study followed 215 people newly diagnosed with HIV in Hong Kong to see how often they developed non-AIDS conditions like high blood pressure, diabetes, bone thinning, and kidney problems. Participants were on different anti-retroviral regimens, and researchers compared the r…

This study followed 180 people with anorexia nervosa for up to 4 years to see how their bone density changed over time. Researchers measured bone mineral density using a special X-ray scan and also checked blood levels of certain hormones linked to fat tissue. The goal was to und…

This completed study tested a centralized Bone Health Service model to improve osteoporosis screening in male veterans aged 65 and older. Over 3,500 veterans from primary care teams took part. The goal was to see if a dedicated bone health team could increase screening rates and …

This study looked at whether eating more Greek yogurt for 8 weeks could improve bone health and lower inflammation in adults aged 55 and older. Forty participants either ate yogurt with or without exercise, or just exercised without yogurt. Researchers measured blood markers of b…

This study looked at 66 postmenopausal women with osteoporosis who were either taking alendronate (a common bone-strengthening drug) or not. Researchers measured how well the jawbone healed after a tooth extraction using X-rays taken right after, then at 30 and 90 days. The goal …